Magnesium in PDB 4qj5: Structure of A Fragment of Human Phospholipase C-BETA3 DELTA472-581, Bound to IP3 and in Complex with Galphaq

Enzymatic activity of Structure of A Fragment of Human Phospholipase C-BETA3 DELTA472-581, Bound to IP3 and in Complex with Galphaq

All present enzymatic activity of Structure of A Fragment of Human Phospholipase C-BETA3 DELTA472-581, Bound to IP3 and in Complex with Galphaq:
3.1.4.11;

Protein crystallography data

The structure of Structure of A Fragment of Human Phospholipase C-BETA3 DELTA472-581, Bound to IP3 and in Complex with Galphaq, PDB code: 4qj5 was solved by A.M.Lyon, J.J.G.Tesmer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	29.34 / 3.41
*Space group*	C 1 2 1
*Cell size a, b, c (Å), α, β, γ (°)*	205.918, 89.869, 93.261, 90.00, 101.80, 90.00
*R / R_free (%)*	21.2 / 27.7

Other elements in 4qj5:

The structure of Structure of A Fragment of Human Phospholipase C-BETA3 DELTA472-581, Bound to IP3 and in Complex with Galphaq also contains other interesting chemical elements:

Fluorine	(F)	4 atoms
Aluminium	(Al)	1 atom
Calcium	(Ca)	1 atom

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Structure of A Fragment of Human Phospholipase C-BETA3 DELTA472-581, Bound to IP3 and in Complex with Galphaq (pdb code 4qj5). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Structure of A Fragment of Human Phospholipase C-BETA3 DELTA472-581, Bound to IP3 and in Complex with Galphaq, PDB code: 4qj5:

Magnesium binding site 1 out of 1 in 4qj5

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Magnesium Binding Sites List in 4qj5

Magnesium binding site 1 out of 1 in the Structure of A Fragment of Human Phospholipase C-BETA3 DELTA472-581, Bound to IP3 and in Complex with Galphaq

Mono view

Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structure of A Fragment of Human Phospholipase C-BETA3 DELTA472-581, Bound to IP3 and in Complex with Galphaq within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Mg402 b:58.8 occ:1.00	O2B	A:GDP400	2.2	58.2	1.0
	OG1	A:THR186	2.2	59.9	1.0
	OG	A:SER53	2.2	59.0	1.0
	F1	A:ALF401	2.2	59.0	1.0
	O	A:HOH502	2.4	12.7	1.0
	CB	A:SER53	2.8	58.8	1.0
	O2A	A:GDP400	2.9	57.1	1.0
	O3B	A:GDP400	3.0	58.1	1.0
	F3	A:ALF401	3.0	59.3	1.0
	PB	A:GDP400	3.1	57.8	1.0
	CB	A:THR186	3.2	60.5	1.0
	AL	A:ALF401	3.4	59.0	1.0
	PA	A:GDP400	3.6	57.0	1.0
	O1A	A:GDP400	3.8	57.2	1.0
	O3A	A:GDP400	3.8	57.3	1.0
	N	A:SER53	3.9	58.6	1.0
	CA	A:SER53	4.0	58.8	1.0
	O	A:VAL184	4.1	58.1	1.0
	CG2	A:THR186	4.1	61.0	1.0
	N	A:THR186	4.2	60.0	1.0
	CA	A:THR186	4.3	60.8	1.0
	NH1	A:ARG183	4.4	56.3	1.0
	O1B	A:GDP400	4.4	58.0	1.0
	O	A:HOH501	4.5	26.7	1.0
	F4	A:ALF401	4.5	59.0	1.0
	OD2	A:ASP205	4.6	67.2	1.0
	C	A:PRO185	4.9	59.6	1.0

Reference:

A.M.Lyon, J.A.Begley, T.Manett, J.J.G.Tesmer. Molecular Mechanisms of Plcbeta Regulation. Structure 2014.
ISSN: ISSN 0969-2126

Page generated: Tue Aug 20 02:00:58 2024

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