Magnesium in PDB 4ql3: Crystal Structure of A Gdp-Bound G12R Oncogenic Mutant of Human Gtpase Kras

All present enzymatic activity of Crystal Structure of A Gdp-Bound G12R Oncogenic Mutant of Human Gtpase Kras:
3.6.5.2;

The structure of Crystal Structure of A Gdp-Bound G12R Oncogenic Mutant of Human Gtpase Kras, PDB code: 4ql3 was solved by J.C.Hunter, A.Manandhar, D.Gurbani, Z.Chen, K.D.Westover, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.50 / 1.04
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	39.125, 40.908, 91.806, 90.00, 90.00, 90.00
R / Rfree (%)	13.8 / 16.2

The binding sites of Magnesium atom in the Crystal Structure of A Gdp-Bound G12R Oncogenic Mutant of Human Gtpase Kras (pdb code 4ql3). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of A Gdp-Bound G12R Oncogenic Mutant of Human Gtpase Kras, PDB code: 4ql3:

Magnesium binding site 1 out of 1 in the Crystal Structure of A Gdp-Bound G12R Oncogenic Mutant of Human Gtpase Kras


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of A Gdp-Bound G12R Oncogenic Mutant of Human Gtpase Kras within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg202 b:7.3 occ:1.00 O2B A:GDP201 2.0 7.1 1.0 O A:HOH304 2.1 7.6 1.0 O A:HOH303 2.1 8.2 1.0 OG A:SER17 2.1 7.6 1.0 O A:HOH301 2.1 8.2 1.0 O A:HOH305 2.1 8.3 1.0 HB2 A:SER17 3.2 8.7 1.0 CB A:SER17 3.2 7.2 1.0 PB A:GDP201 3.3 6.9 1.0 H A:SER17 3.3 8.4 1.0 HA A:PRO34 3.4 11.4 1.0 HD2 A:TYR32 3.5 15.9 1.0 O3B A:GDP201 3.6 7.8 1.0 HB3 A:SER17 3.8 8.7 1.0 N A:SER17 3.9 7.0 1.0 HB2 A:LYS16 3.9 8.5 1.0 HE2 A:TYR32 4.0 22.6 1.0 CA A:SER17 4.1 7.2 1.0 O2A A:GDP201 4.1 9.4 1.0 HE2 A:LYS16 4.1 10.6 1.0 OD2 A:ASP57 4.1 8.3 1.0 OD1 A:ASP57 4.2 7.9 1.0 O A:PRO34 4.2 9.1 1.0 CD2 A:TYR32 4.3 13.3 1.0 O3A A:GDP201 4.3 7.9 1.0 CA A:PRO34 4.3 9.5 1.0 O1B A:GDP201 4.3 7.1 1.0 O A:ASP33 4.3 8.9 1.0 HA A:SER17 4.4 8.7 1.0 O A:ILE36 4.4 9.0 1.0 HB2 A:ALA59 4.5 11.1 1.0 PA A:GDP201 4.5 7.6 1.0 CE2 A:TYR32 4.6 18.9 1.0 C A:PRO34 4.6 8.1 1.0 CG A:ASP57 4.6 7.8 1.0 O A:THR58 4.6 7.3 1.0 HZ2 A:LYS16 4.7 9.4 1.0 O1A A:GDP201 4.7 9.2 1.0 HZ1 A:LYS16 4.8 9.4 1.0 O A:TYR32 4.8 12.2 1.0 CB A:LYS16 4.9 7.1 1.0 HA A:ALA59 4.9 9.6 1.0 CE A:LYS16 5.0 8.8 1.0 C A:LYS16 5.0 6.3 1.0 O A:HOH461 5.0 11.3 1.0

J.C.Hunter, A.Manandhar, M.A.Carrasco, D.Gurbani, S.Gondi, K.D.Westover. Biochemical and Structural Analysis of Common Cancer-Associated Kras Mutations. Mol Cancer Res. V. 13 1325 2015.
ISSN: ISSN 1541-7786
PubMed: 26037647
DOI: 10.1158/1541-7786.MCR-15-0203