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Magnesium in PDB 4qz1: Ycp BETA5-M45T Mutant in Complex with the Epoxyketone Inhibitor Onx 0914
Enzymatic activity of Ycp BETA5-M45T Mutant in Complex with the Epoxyketone Inhibitor Onx 0914
All present enzymatic activity of Ycp BETA5-M45T Mutant in Complex with the Epoxyketone Inhibitor Onx 0914:
3.4.25.1;
3.4.25.1;
Protein crystallography data
The structure of Ycp BETA5-M45T Mutant in Complex with the Epoxyketone Inhibitor Onx 0914, PDB code: 4qz1
was solved by
E.M.Huber,
W.Heinemeyer,
M.Groll,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 15.00 / 3.00 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 137.180, 298.800, 146.830, 90.00, 113.02, 90.00 |
| R / Rfree (%) | 17.6 / 21.6 |
Other elements in 4qz1:
The structure of Ycp BETA5-M45T Mutant in Complex with the Epoxyketone Inhibitor Onx 0914 also contains other interesting chemical elements:
| Chlorine | (Cl) | 2 atoms |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Ycp BETA5-M45T Mutant in Complex with the Epoxyketone Inhibitor Onx 0914
(pdb code 4qz1). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Ycp BETA5-M45T Mutant in Complex with the Epoxyketone Inhibitor Onx 0914, PDB code: 4qz1:
Jump to Magnesium binding site number: 1; 2; 3;
In total 3 binding sites of Magnesium where determined in the Ycp BETA5-M45T Mutant in Complex with the Epoxyketone Inhibitor Onx 0914, PDB code: 4qz1:
Jump to Magnesium binding site number: 1; 2; 3;
Magnesium binding site 1 out of 3 in 4qz1
Go back to
Magnesium Binding Sites List in 4qz1
Magnesium binding site 1 out
of 3 in the Ycp BETA5-M45T Mutant in Complex with the Epoxyketone Inhibitor Onx 0914
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Ycp BETA5-M45T Mutant in Complex with the Epoxyketone Inhibitor Onx 0914 within 5.0Å range:
|
Magnesium binding site 2 out of 3 in 4qz1
Go back to
Magnesium Binding Sites List in 4qz1
Magnesium binding site 2 out
of 3 in the Ycp BETA5-M45T Mutant in Complex with the Epoxyketone Inhibitor Onx 0914
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 2 of Ycp BETA5-M45T Mutant in Complex with the Epoxyketone Inhibitor Onx 0914 within 5.0Å range:
|
Magnesium binding site 3 out of 3 in 4qz1
Go back to
Magnesium Binding Sites List in 4qz1
Magnesium binding site 3 out
of 3 in the Ycp BETA5-M45T Mutant in Complex with the Epoxyketone Inhibitor Onx 0914
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 3 of Ycp BETA5-M45T Mutant in Complex with the Epoxyketone Inhibitor Onx 0914 within 5.0Å range:
|
Reference:
E.M.Huber,
W.Heinemeyer,
M.Groll.
Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and Onx 0914. Structure 2015.
ISSN: ISSN 0969-2126
PubMed: 25599643
DOI: 10.1016/J.STR.2014.11.019
Page generated: Tue Aug 20 02:36:18 2024
ISSN: ISSN 0969-2126
PubMed: 25599643
DOI: 10.1016/J.STR.2014.11.019
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