Magnesium in PDB 4tlt: Crystal Structure of Human Transthyretin

The structure of Crystal Structure of Human Transthyretin, PDB code: 4tlt was solved by L.Saelices, D.Cascio, M.Sawaya, D.S.Eisenberg, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.49 / 1.70
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	41.240, 84.240, 63.080, 90.00, 90.00, 90.00
R / Rfree (%)	19.7 / 23.2

The binding sites of Magnesium atom in the Crystal Structure of Human Transthyretin (pdb code 4tlt). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of Human Transthyretin, PDB code: 4tlt:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Crystal Structure of Human Transthyretin


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Human Transthyretin within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg201 b:31.5 occ:1.00 O A:HOH301 2.2 40.2 1.0 OD1 A:ASP99 2.3 44.2 1.0 OE1 A:GLU66 2.5 31.4 1.0 O A:HOH309 2.5 42.9 1.0 O A:ASP99 2.7 35.2 1.0 CD A:GLU66 3.4 45.3 1.0 CG A:ASP99 3.5 42.6 1.0 C A:ASP99 3.7 34.7 1.0 OE2 A:GLU66 3.7 36.2 1.0 CA A:ASP99 3.8 26.1 1.0 CB A:ASP99 4.2 27.8 1.0 OD2 A:ASP99 4.5 49.7 1.0 CG A:GLU66 4.8 32.7 1.0 N A:SER100 4.9 33.4 1.0 O A:ASN98 5.0 26.2 1.0

Magnesium binding site 2 out of 2 in the Crystal Structure of Human Transthyretin


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of Human Transthyretin within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg201 b:30.2 occ:1.00 OE1 B:GLU66 2.3 30.3 1.0 O B:HOH307 2.5 47.4 1.0 O B:HOH303 2.5 47.5 1.0 OE2 B:GLU66 2.8 40.1 1.0 CD B:GLU66 2.9 35.0 1.0 CG B:GLU66 4.3 29.9 1.0 OD1 B:ASN98 4.7 59.5 1.0 CB B:GLU66 4.8 25.1 1.0

L.Saelices, L.M.Johnson, W.Y.Liang, M.R.Sawaya, D.Cascio, P.Ruchala, J.Whitelegge, L.Jiang, R.Riek, D.S.Eisenberg. Uncovering the Mechanism of Aggregation of Human Transthyretin. J.Biol.Chem. V. 290 28932 2015.
ISSN: ESSN 1083-351X
PubMed: 26459562
DOI: 10.1074/JBC.M115.659912