|
Atomistry » Magnesium » PDB 4tyq-4u98 » 4u45 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 4tyq-4u98 » 4u45 » |
Magnesium in PDB 4u45: MAP4K4 in Complex with Inhibitor (Compound 25)Enzymatic activity of MAP4K4 in Complex with Inhibitor (Compound 25)
All present enzymatic activity of MAP4K4 in Complex with Inhibitor (Compound 25):
2.7.11.1; Protein crystallography data
The structure of MAP4K4 in Complex with Inhibitor (Compound 25), PDB code: 4u45
was solved by
S.F.Harris,
P.Wu,
M.Coons,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the MAP4K4 in Complex with Inhibitor (Compound 25)
(pdb code 4u45). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the MAP4K4 in Complex with Inhibitor (Compound 25), PDB code: 4u45: Jump to Magnesium binding site number: 1; 2; Magnesium binding site 1 out of 2 in 4u45Go back to Magnesium Binding Sites List in 4u45
Magnesium binding site 1 out
of 2 in the MAP4K4 in Complex with Inhibitor (Compound 25)
Mono view Stereo pair view
Magnesium binding site 2 out of 2 in 4u45Go back to Magnesium Binding Sites List in 4u45
Magnesium binding site 2 out
of 2 in the MAP4K4 in Complex with Inhibitor (Compound 25)
Mono view Stereo pair view
Reference:
L.Wang,
M.Stanley,
J.W.Boggs,
T.D.Crawford,
B.J.Bravo,
A.M.Giannetti,
S.F.Harris,
S.R.Magnuson,
J.Nonomiya,
S.Schmidt,
P.Wu,
W.Ye,
S.E.Gould,
L.J.Murray,
C.O.Ndubaku,
H.Chen.
Fragment-Based Identification and Optimization of A Class of Potent Pyrrolo[2,1-F][1,2,4]Triazine MAP4K4 Inhibitors. Bioorg.Med.Chem.Lett. V. 24 4546 2014.
Page generated: Mon Dec 14 19:35:45 2020
ISSN: ESSN 1464-3405 PubMed: 25139565 DOI: 10.1016/J.BMCL.2014.07.071 |
Last articlesZn in 8WB0Zn in 8WAX Zn in 8WAU Zn in 8WAZ Zn in 8WAY Zn in 8WAV Zn in 8WAW Zn in 8WAT Zn in 8W7M Zn in 8WD3 |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |