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Atomistry » Magnesium » PDB 4um7-4uux » 4unr | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 4um7-4uux » 4unr » |
Magnesium in PDB 4unr: Mtb Tmk in Complex with Compound 23Enzymatic activity of Mtb Tmk in Complex with Compound 23
All present enzymatic activity of Mtb Tmk in Complex with Compound 23:
2.7.4.9; Protein crystallography data
The structure of Mtb Tmk in Complex with Compound 23, PDB code: 4unr
was solved by
J.A.Read,
S.Hussein,
H.Gingell,
J.Tucker,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Mtb Tmk in Complex with Compound 23
(pdb code 4unr). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Mtb Tmk in Complex with Compound 23, PDB code: 4unr: Jump to Magnesium binding site number: 1; 2; Magnesium binding site 1 out of 2 in 4unrGo back to![]() ![]()
Magnesium binding site 1 out
of 2 in the Mtb Tmk in Complex with Compound 23
![]() Mono view ![]() Stereo pair view
Magnesium binding site 2 out of 2 in 4unrGo back to![]() ![]()
Magnesium binding site 2 out
of 2 in the Mtb Tmk in Complex with Compound 23
![]() Mono view ![]() Stereo pair view
Reference:
M.Naik,
A.Raichurkar,
B.S.Bandodkar,
B.V.Varun,
S.Bhat,
R.Kalkhambkar,
K.Murugan,
R.Menon,
J.Bhat,
B.Paul,
H.Iyer,
S.Hussein,
J.A.Tucker,
M.Vogtherr,
K.J.Embrey,
H.Mcmiken,
S.Prasad,
A.Gill,
B.G.Ugarkar,
J.Venkatraman,
J.Read,
M.Panda.
Structure Guided Lead Generation For M. Tuberculosis Thymidylate Kinase (Mtb Tmk): Discovery of 3-Cyanopyridone and 1,6-Naphthyridin-2-One As Potent Inhibitors. J.Med.Chem. V. 58 753 2015.
Page generated: Tue Aug 20 04:54:08 2024
ISSN: ISSN 0022-2623 PubMed: 25486447 DOI: 10.1021/JM5012947 |
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