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Magnesium in PDB 4v25: Ver-246608, A Novel Pan-Isoform Atp Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer CellsEnzymatic activity of Ver-246608, A Novel Pan-Isoform Atp Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer Cells
All present enzymatic activity of Ver-246608, A Novel Pan-Isoform Atp Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer Cells:
2.7.11.2; Protein crystallography data
The structure of Ver-246608, A Novel Pan-Isoform Atp Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer Cells, PDB code: 4v25
was solved by
J.D.Moore,
A.Staniszewska,
T.Shaw,
J.D'alessandro,
B.Davis,
A.Surgenor,
L.Baker,
N.Matassova,
J.Murray,
A.Macias,
P.Brough,
M.Wood,
P.C.Mahon,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4v25:
The structure of Ver-246608, A Novel Pan-Isoform Atp Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer Cells also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Ver-246608, A Novel Pan-Isoform Atp Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer Cells
(pdb code 4v25). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Ver-246608, A Novel Pan-Isoform Atp Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer Cells, PDB code: 4v25: Magnesium binding site 1 out of 1 in 4v25Go back to Magnesium Binding Sites List in 4v25
Magnesium binding site 1 out
of 1 in the Ver-246608, A Novel Pan-Isoform Atp Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer Cells
Mono view Stereo pair view
Reference:
J.D.Moore,
A.Staniszewska,
T.Shaw,
J.D'alessandro,
B.Davis,
A.Surgenor,
L.Baker,
N.Matassova,
J.Murray,
A.Macias,
P.Brough,
M.Wood,
P.C.Mahon.
Ver-246608, A Novel Pan-Isoform Atp Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer Cells. Oncotarget 2014.
Page generated: Mon Dec 14 19:39:30 2020
ISSN: ESSN 1949-2553 PubMed: 25404640 |
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