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Atomistry » Magnesium » PDB 4uux-4w5n » 4v26 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 4uux-4w5n » 4v26 » |
Magnesium in PDB 4v26: Ver-246608, A Novel Pan-Isoform Atp Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer CellsEnzymatic activity of Ver-246608, A Novel Pan-Isoform Atp Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer Cells
All present enzymatic activity of Ver-246608, A Novel Pan-Isoform Atp Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer Cells:
2.7.11.2; Protein crystallography data
The structure of Ver-246608, A Novel Pan-Isoform Atp Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer Cells, PDB code: 4v26
was solved by
J.D.Moore,
A.Staniszewska,
T.Shaw,
J.D'alessandro,
B.Davis,
A.Surgenor,
L.Baker,
N.Matassova,
J.Murray,
A.Macias,
P.Brough,
M.Wood,
P.C.Mahon,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4v26:
The structure of Ver-246608, A Novel Pan-Isoform Atp Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer Cells also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Ver-246608, A Novel Pan-Isoform Atp Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer Cells
(pdb code 4v26). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Ver-246608, A Novel Pan-Isoform Atp Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer Cells, PDB code: 4v26: Jump to Magnesium binding site number: 1; 2; Magnesium binding site 1 out of 2 in 4v26Go back to Magnesium Binding Sites List in 4v26
Magnesium binding site 1 out
of 2 in the Ver-246608, A Novel Pan-Isoform Atp Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer Cells
Mono view Stereo pair view
Magnesium binding site 2 out of 2 in 4v26Go back to Magnesium Binding Sites List in 4v26
Magnesium binding site 2 out
of 2 in the Ver-246608, A Novel Pan-Isoform Atp Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer Cells
Mono view Stereo pair view
Reference:
J.D.Moore,
A.Staniszewska,
T.Shaw,
J.D'alessandro,
B.Davis,
A.Surgenor,
L.Baker,
N.Matassova,
J.Murray,
A.Macias,
P.Brough,
M.Wood,
P.C.Mahon.
Ver-246608, A Novel Pan-Isoform Atp Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer Cells. Oncotarget 2014.
Page generated: Tue Aug 20 05:05:59 2024
ISSN: ESSN 1949-2553 PubMed: 25404640 |
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