Magnesium in PDB 4w5n: The Crystal Structure of Human ARGONAUTE2 Bound to A Defined Guide Rna

The structure of The Crystal Structure of Human ARGONAUTE2 Bound to A Defined Guide Rna, PDB code: 4w5n was solved by N.T.Schirle, J.Sheu-Gruttadauria, I.J.Macrae, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.98 / 2.90
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	63.117, 108.870, 68.071, 90.00, 106.93, 90.00
R / Rfree (%)	21.7 / 25.3

The binding sites of Magnesium atom in the The Crystal Structure of Human ARGONAUTE2 Bound to A Defined Guide Rna (pdb code 4w5n). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the The Crystal Structure of Human ARGONAUTE2 Bound to A Defined Guide Rna, PDB code: 4w5n:

Magnesium binding site 1 out of 1 in the The Crystal Structure of Human ARGONAUTE2 Bound to A Defined Guide Rna


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of The Crystal Structure of Human ARGONAUTE2 Bound to A Defined Guide Rna within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg904 b:56.4 occ:1.00 OD1 A:ASP597 2.1 50.5 1.0 O A:VAL598 2.9 57.0 1.0 CG A:ASP597 3.2 48.7 1.0 OD2 A:ASP597 3.7 51.0 1.0 O A:ASP669 3.7 51.3 1.0 C A:VAL598 3.8 52.5 1.0 OE2 A:GLU637 3.9 49.8 1.0 N A:VAL598 3.9 44.8 1.0 CA A:GLY670 4.1 46.2 1.0 C A:ASP669 4.4 47.1 1.0 CA A:VAL598 4.5 49.2 1.0 CB A:ASP597 4.5 46.0 1.0 OE1 A:GLU637 4.5 48.6 1.0 CD A:GLU637 4.6 48.0 1.0 N A:GLY670 4.7 45.4 1.0 N A:THR599 4.7 53.5 1.0 OD2 A:ASP669 4.7 48.4 1.0 C A:ASP597 4.7 47.4 1.0 CA A:ASP597 4.8 45.3 1.0 CA A:THR599 4.9 56.5 1.0 O A:GLY670 5.0 48.2 1.0

N.T.Schirle, J.Sheu-Gruttadauria, I.J.Macrae. Gene Regulation. Structural Basis For Microrna Targeting. Science V. 346 608 2014.
ISSN: ESSN 1095-9203
PubMed: 25359968
DOI: 10.1126/SCIENCE.1258040