Magnesium in PDB 4wa7: Crystal Structure of A Gdp-Bound Q61L Oncogenic Mutant of Human Gt- Pase Kras

The structure of Crystal Structure of A Gdp-Bound Q61L Oncogenic Mutant of Human Gt- Pase Kras, PDB code: 4wa7 was solved by J.C.Hunter, A.Manandhar, D.Gurbani, Z.Chen, K.D.Westover, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.72 / 1.99
Space group	P 63
Cell size a, b, c (Å), α, β, γ (°)	82.493, 82.493, 40.761, 90.00, 90.00, 120.00
R / Rfree (%)	18.4 / 23.3

The binding sites of Magnesium atom in the Crystal Structure of A Gdp-Bound Q61L Oncogenic Mutant of Human Gt- Pase Kras (pdb code 4wa7). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of A Gdp-Bound Q61L Oncogenic Mutant of Human Gt- Pase Kras, PDB code: 4wa7:

Magnesium binding site 1 out of 1 in the Crystal Structure of A Gdp-Bound Q61L Oncogenic Mutant of Human Gt- Pase Kras


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of A Gdp-Bound Q61L Oncogenic Mutant of Human Gt- Pase Kras within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg202 b:36.2 occ:1.00 O2B A:GDP201 2.0 29.5 1.0 O A:HOH331 2.1 29.0 1.0 OG A:SER17 2.1 30.6 1.0 O A:HOH318 2.1 33.4 1.0 O A:HOH317 2.2 29.5 1.0 O A:HOH319 2.2 37.2 1.0 HB2 A:SER17 3.1 37.1 1.0 CB A:SER17 3.2 30.9 1.0 PB A:GDP201 3.3 29.0 1.0 H A:SER17 3.3 38.3 1.0 HA A:PRO34 3.5 40.8 1.0 O1B A:GDP201 3.5 33.1 1.0 HD2 A:TYR32 3.6 42.4 1.0 HB3 A:SER17 3.9 37.1 1.0 N A:SER17 3.9 31.9 1.0 HB2 A:LYS16 3.9 38.5 1.0 O1A A:GDP201 3.9 31.1 1.0 CA A:SER17 4.1 29.2 1.0 OD2 A:ASP57 4.1 41.5 1.0 HE2 A:LYS16 4.1 37.8 1.0 OD1 A:ASP57 4.2 44.1 1.0 O A:ASP33 4.2 36.8 1.0 O3A A:GDP201 4.3 29.6 1.0 O3B A:GDP201 4.3 28.7 1.0 CA A:PRO34 4.4 34.0 1.0 HA A:SER17 4.4 35.1 1.0 CD2 A:TYR32 4.4 36.2 1.0 O A:PRO34 4.4 44.7 1.0 PA A:GDP201 4.5 27.9 1.0 HB3 A:TYR32 4.5 36.6 1.0 O2A A:GDP201 4.6 31.5 1.0 CG A:ASP57 4.6 41.0 1.0 HZ3 A:LYS16 4.6 36.9 1.0 O A:ILE36 4.6 40.2 1.0 O A:THR58 4.6 42.4 1.0 HA A:ALA59 4.7 60.6 1.0 HE2 A:TYR32 4.7 44.1 1.0 HZ2 A:LYS16 4.7 36.9 1.0 C A:PRO34 4.7 41.4 1.0 CB A:LYS16 4.8 32.1 1.0 O A:HOH324 4.9 36.2 1.0 O A:TYR32 4.9 33.2 1.0 C A:LYS16 4.9 31.6 1.0 H A:LYS16 5.0 32.3 1.0 CE2 A:TYR32 5.0 39.1 1.0 NZ A:LYS16 5.0 30.7 1.0 CE A:LYS16 5.0 31.5 1.0 C A:ASP33 5.0 33.0 1.0

J.C.Hunter, A.Manandhar, M.A.Carrasco, D.Gurbani, S.Gondi, K.D.Westover. Biochemical and Structural Analysis of Common Cancer-Associated Kras Mutations. Mol Cancer Res. V. 13 1325 2015.
ISSN: ESSN 1557-3125
PubMed: 26037647
DOI: 10.1158/1541-7786.MCR-15-0203