Magnesium in PDB 4x2b: K20A Rna Dependent Rna Polymerase Mutant From Foot-and-Mouth Disease Virus Complexed with An Rna

Enzymatic activity of K20A Rna Dependent Rna Polymerase Mutant From Foot-and-Mouth Disease Virus Complexed with An Rna

All present enzymatic activity of K20A Rna Dependent Rna Polymerase Mutant From Foot-and-Mouth Disease Virus Complexed with An Rna:
2.7.7.48;

Protein crystallography data

The structure of K20A Rna Dependent Rna Polymerase Mutant From Foot-and-Mouth Disease Virus Complexed with An Rna, PDB code: 4x2b was solved by N.Verdaguer, C.Ferrer-Orta, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	47.11 / 2.94
*Space group*	P 4₁ 2₁ 2
*Cell size a, b, c (Å), α, β, γ (°)*	94.222, 94.222, 121.515, 90.00, 90.00, 90.00
*R / R_free (%)*	21.5 / 25.9

Magnesium Binding Sites:

The binding sites of Magnesium atom in the K20A Rna Dependent Rna Polymerase Mutant From Foot-and-Mouth Disease Virus Complexed with An Rna (pdb code 4x2b). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the K20A Rna Dependent Rna Polymerase Mutant From Foot-and-Mouth Disease Virus Complexed with An Rna, PDB code: 4x2b:

Magnesium binding site 1 out of 1 in 4x2b

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Magnesium Binding Sites List in 4x2b

Magnesium binding site 1 out of 1 in the K20A Rna Dependent Rna Polymerase Mutant From Foot-and-Mouth Disease Virus Complexed with An Rna

Mono view

Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of K20A Rna Dependent Rna Polymerase Mutant From Foot-and-Mouth Disease Virus Complexed with An Rna within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Mg501 b:63.1 occ:1.00	OD1	A:ASP238	2.5	72.5	1.0
	OD1	A:ASP339	2.8	62.4	1.0
	OD1	A:ASP240	2.8	69.9	1.0
	O	A:THR384	3.5	64.8	1.0
	O	A:VAL239	3.6	67.3	1.0
	CG	A:ASP238	3.6	71.5	1.0
	OD2	A:ASP238	4.0	72.2	1.0
	CG	A:ASP339	4.0	61.7	1.0
	CG	A:ASP240	4.0	70.0	1.0
	O	A:ILE340	4.1	63.7	1.0
	C	A:VAL239	4.5	68.6	1.0
	N	A:ILE340	4.5	62.0	1.0
	C	A:THR384	4.6	63.3	1.0
	OD2	A:ASP240	4.6	71.2	1.0
	OD2	A:ASP339	4.7	62.5	1.0
	CB	A:ALA367	4.7	82.9	1.0
	N	A:VAL239	4.8	68.9	1.0
	CB	A:ASP238	4.9	71.4	1.0
	C	A:ASP238	4.9	69.7	1.0
	CA	A:ASP339	4.9	60.3	1.0

Reference:

C.Ferrer-Orta, I.De La Higuera, F.Caridi, M.T.Sanchez-Aparicio, E.Moreno, C.Perales, K.Singh, S.G.Sarafianos, F.Sobrino, E.Domingo, N.Verdaguer. Multifunctionality of A Picornavirus Polymerase Domain: Nuclear Localization Signal and Nucleotide Recognition. J.Virol. 2015.
ISSN: ESSN 1098-5514
PubMed: 25903341
DOI: 10.1128/JVI.03283-14

Page generated: Tue Aug 20 14:02:59 2024

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