Magnesium in PDB 4x6r: An Isoform-Specific Myristylation Switch Targets Riib Pka Holoenzymes to Membranes

All present enzymatic activity of An Isoform-Specific Myristylation Switch Targets Riib Pka Holoenzymes to Membranes:
2.7.11.11;

The structure of An Isoform-Specific Myristylation Switch Targets Riib Pka Holoenzymes to Membranes, PDB code: 4x6r was solved by P.Zhang, F.Ye, A.C.Bastidas, A.P.Kornev, M.H.Ginsberg, J.Wu, S.S.Taylor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	62.88 / 2.40
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	125.760, 125.760, 140.881, 90.00, 90.00, 120.00
R / Rfree (%)	18.4 / 23.4

The binding sites of Magnesium atom in the An Isoform-Specific Myristylation Switch Targets Riib Pka Holoenzymes to Membranes (pdb code 4x6r). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the An Isoform-Specific Myristylation Switch Targets Riib Pka Holoenzymes to Membranes, PDB code: 4x6r:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the An Isoform-Specific Myristylation Switch Targets Riib Pka Holoenzymes to Membranes


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of An Isoform-Specific Myristylation Switch Targets Riib Pka Holoenzymes to Membranes within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg407 b:68.5 occ:1.00 O2A A:ATP402 2.3 73.5 1.0 OD1 A:ASN171 2.4 38.1 1.0 O2G A:ATP402 2.7 63.6 1.0 O3B A:ATP402 3.0 93.7 1.0 PG A:ATP402 3.4 93.1 1.0 CG A:ASN171 3.4 35.1 1.0 OD2 A:ASP184 3.5 54.4 1.0 O3' A:ATP402 3.6 53.2 1.0 PA A:ATP402 3.6 96.7 1.0 ND2 A:ASN171 3.8 37.5 1.0 C5' A:ATP402 4.0 59.3 1.0 O5' A:ATP402 4.0 70.7 1.0 O1G A:ATP402 4.1 65.9 1.0 O3A A:ATP402 4.2 86.5 1.0 PB A:ATP402 4.2 0.5 1.0 CE A:LYS168 4.3 35.7 1.0 NZ A:LYS168 4.3 33.3 1.0 C3' A:ATP402 4.4 63.4 1.0 NH2 B:ARG94 4.4 53.9 1.0 CG A:ASP184 4.4 48.8 1.0 CB A:ASP184 4.5 42.2 1.0 O3G A:ATP402 4.5 69.1 1.0 O A:GLU170 4.6 38.1 1.0 O A:THR51 4.6 57.8 1.0 C4' A:ATP402 4.7 58.5 1.0 CB A:GLU170 4.7 34.3 1.0 O2B A:ATP402 4.7 83.9 1.0 CB A:ASN171 4.7 35.9 1.0 C A:GLU170 4.9 37.6 1.0 O1A A:ATP402 5.0 70.2 1.0 CA A:ASN171 5.0 31.4 1.0 N A:ASN171 5.0 31.8 1.0

Magnesium binding site 2 out of 2 in the An Isoform-Specific Myristylation Switch Targets Riib Pka Holoenzymes to Membranes


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of An Isoform-Specific Myristylation Switch Targets Riib Pka Holoenzymes to Membranes within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg408 b:68.2 occ:1.00 O2B A:ATP402 2.5 83.9 1.0 O3G A:ATP402 2.6 69.1 1.0 OD1 A:ASP184 3.1 49.5 1.0 O A:HOH571 3.1 49.5 1.0 OD2 A:ASP184 3.3 54.4 1.0 CD1 A:PHE54 3.4 68.3 1.0 CG A:ASP184 3.6 48.8 1.0 CA A:GLY186 3.7 32.7 1.0 PB A:ATP402 3.8 0.5 1.0 CE1 A:PHE54 3.9 70.4 1.0 PG A:ATP402 4.0 93.1 1.0 N A:GLY186 4.3 39.4 1.0 O3B A:ATP402 4.3 93.7 1.0 NZ A:LYS72 4.3 63.7 1.0 CE1 A:PHE187 4.3 39.6 1.0 C A:GLY186 4.3 38.3 1.0 OD2 A:ASP166 4.3 58.8 1.0 CZ A:PHE187 4.4 44.2 1.0 O1B A:ATP402 4.4 81.6 1.0 CG A:PHE54 4.5 73.7 1.0 N A:PHE187 4.7 34.5 1.0 CD1 A:PHE187 4.7 33.6 1.0 O2G A:ATP402 4.7 63.6 1.0 CE2 A:PHE187 4.8 41.3 1.0 CB A:PHE54 4.8 78.6 1.0 O A:GLY186 4.9 39.4 1.0 CB B:ALA97 5.0 43.7 1.0

P.Zhang, F.Ye, A.C.Bastidas, A.P.Kornev, J.Wu, M.H.Ginsberg, S.S.Taylor. An Isoform-Specific Myristylation Switch Targets Type II Pka Holoenzymes to Membranes. Structure V. 23 1563 2015.
ISSN: ISSN 0969-2126
PubMed: 26278174
DOI: 10.1016/J.STR.2015.07.007