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Atomistry » Magnesium » PDB 4xtj-4y2p » 4xud » |
Magnesium in PDB 4xud: Synthesis and Evaluation of Heterocyclic Catechol Mimics As Inhibitors of Catechol-O-Methyltransferase (Comt): Structure with CMPD32 ([1- (Biphenyl-3-Yl)-5-Hydroxy-4-Oxo-1,4-Dihydropyridin-3-Yl]Boronic Acid)Enzymatic activity of Synthesis and Evaluation of Heterocyclic Catechol Mimics As Inhibitors of Catechol-O-Methyltransferase (Comt): Structure with CMPD32 ([1- (Biphenyl-3-Yl)-5-Hydroxy-4-Oxo-1,4-Dihydropyridin-3-Yl]Boronic Acid)
All present enzymatic activity of Synthesis and Evaluation of Heterocyclic Catechol Mimics As Inhibitors of Catechol-O-Methyltransferase (Comt): Structure with CMPD32 ([1- (Biphenyl-3-Yl)-5-Hydroxy-4-Oxo-1,4-Dihydropyridin-3-Yl]Boronic Acid):
2.1.1.6; Protein crystallography data
The structure of Synthesis and Evaluation of Heterocyclic Catechol Mimics As Inhibitors of Catechol-O-Methyltransferase (Comt): Structure with CMPD32 ([1- (Biphenyl-3-Yl)-5-Hydroxy-4-Oxo-1,4-Dihydropyridin-3-Yl]Boronic Acid), PDB code: 4xud
was solved by
T.Allison,
S.Wolkenberg,
J.M.Sanders,
S.M.Soisson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Synthesis and Evaluation of Heterocyclic Catechol Mimics As Inhibitors of Catechol-O-Methyltransferase (Comt): Structure with CMPD32 ([1- (Biphenyl-3-Yl)-5-Hydroxy-4-Oxo-1,4-Dihydropyridin-3-Yl]Boronic Acid)
(pdb code 4xud). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Synthesis and Evaluation of Heterocyclic Catechol Mimics As Inhibitors of Catechol-O-Methyltransferase (Comt): Structure with CMPD32 ([1- (Biphenyl-3-Yl)-5-Hydroxy-4-Oxo-1,4-Dihydropyridin-3-Yl]Boronic Acid), PDB code: 4xud: Magnesium binding site 1 out of 1 in 4xudGo back to Magnesium Binding Sites List in 4xud
Magnesium binding site 1 out
of 1 in the Synthesis and Evaluation of Heterocyclic Catechol Mimics As Inhibitors of Catechol-O-Methyltransferase (Comt): Structure with CMPD32 ([1- (Biphenyl-3-Yl)-5-Hydroxy-4-Oxo-1,4-Dihydropyridin-3-Yl]Boronic Acid)
Mono view Stereo pair view
Reference:
S.T.Harrison,
M.S.Poslusney,
J.J.Mulhearn,
Z.Zhao,
N.R.Kett,
J.W.Schubert,
J.Y.Melamed,
T.J.Allison,
S.B.Patel,
J.M.Sanders,
S.Sharma,
R.F.Smith,
D.L.Hall,
R.G.Robinson,
N.A.Sachs,
P.H.Hutson,
S.E.Wolkenberg,
J.C.Barrow.
Synthesis and Evaluation of Heterocyclic Catechol Mimics As Inhibitors of Catechol-O-Methyltransferase (Comt). Acs Med.Chem.Lett. V. 6 318 2015.
Page generated: Mon Dec 14 19:48:25 2020
ISSN: ISSN 1948-5875 PubMed: 25815153 DOI: 10.1021/ML500502D |
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