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Magnesium in PDB 4y30: Crystal Structure of Human Protein Arginine Methyltransferase PRMT6 Bound to Sah and EPZ020411

Enzymatic activity of Crystal Structure of Human Protein Arginine Methyltransferase PRMT6 Bound to Sah and EPZ020411

All present enzymatic activity of Crystal Structure of Human Protein Arginine Methyltransferase PRMT6 Bound to Sah and EPZ020411:
2.1.1.125;

Protein crystallography data

The structure of Crystal Structure of Human Protein Arginine Methyltransferase PRMT6 Bound to Sah and EPZ020411, PDB code: 4y30 was solved by K.K.Swinger, P.A.Boriack-Sjodin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.51 / 2.10
Space group P 43
Cell size a, b, c (Å), α, β, γ (°) 99.672, 99.672, 89.252, 90.00, 90.00, 90.00
R / Rfree (%) 18 / 22.1

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of Human Protein Arginine Methyltransferase PRMT6 Bound to Sah and EPZ020411 (pdb code 4y30). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Human Protein Arginine Methyltransferase PRMT6 Bound to Sah and EPZ020411, PDB code: 4y30:

Magnesium binding site 1 out of 1 in 4y30

Go back to Magnesium Binding Sites List in 4y30
Magnesium binding site 1 out of 1 in the Crystal Structure of Human Protein Arginine Methyltransferase PRMT6 Bound to Sah and EPZ020411


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Human Protein Arginine Methyltransferase PRMT6 Bound to Sah and EPZ020411 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg403

b:37.9
occ:1.00
O A:HOH580 1.9 31.1 1.0
O A:HOH536 2.1 19.6 1.0
O A:HOH743 4.2 26.7 1.0
O A:HOH569 4.3 24.0 1.0
O A:TRP203 4.3 12.2 1.0
CB A:TRP203 4.3 13.8 1.0
CG A:TRP203 4.6 14.9 1.0
CD1 A:TRP203 4.8 15.7 1.0
CA A:TRP203 4.9 13.0 1.0
C A:TRP203 4.9 12.7 1.0

Reference:

L.H.Mitchell, A.E.Drew, S.Ribich, N.Rioux, K.K.Swinger, S.L.Jacques, T.Lingaraj, P.A.Boriack-Sjodin, N.J.Waters, T.J.Wigle, O.Moradei, L.Jin, T.Riera, M.Porter-Scott, M.P.Moyer, J.J.Smith, R.Chesworth, R.A.Copeland. Aryl Pyrazoles As Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound Acs Med.Chem.Lett. 2015.
ISSN: ISSN 1948-5875
DOI: 10.1021/ACSMEDCHEMLETT.5B00071
Page generated: Tue Aug 20 16:24:50 2024

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