Atomistry » Magnesium » PDB 4yoy-4z4f » 4z3o
Atomistry »
  Magnesium »
    PDB 4yoy-4z4f »
      4z3o »

Magnesium in PDB 4z3o: Quinolone(Moxifloxacin)-Dna Cleavage Complex of Topoisomerase IV From S. Pneumoniae

Enzymatic activity of Quinolone(Moxifloxacin)-Dna Cleavage Complex of Topoisomerase IV From S. Pneumoniae

All present enzymatic activity of Quinolone(Moxifloxacin)-Dna Cleavage Complex of Topoisomerase IV From S. Pneumoniae:
5.99.1.3;

Protein crystallography data

The structure of Quinolone(Moxifloxacin)-Dna Cleavage Complex of Topoisomerase IV From S. Pneumoniae, PDB code: 4z3o was solved by I.Laponogov, D.A.Veselkov, X.-S.Pan, J.Selvarajah, I.M.-T.Crevel, L.M.Fisher, M.R.Sanderson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 70.34 / 3.44
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 157.760, 157.760, 211.020, 90.00, 90.00, 120.00
R / Rfree (%) 18.2 / 21.2

Other elements in 4z3o:

The structure of Quinolone(Moxifloxacin)-Dna Cleavage Complex of Topoisomerase IV From S. Pneumoniae also contains other interesting chemical elements:

Fluorine (F) 2 atoms

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Quinolone(Moxifloxacin)-Dna Cleavage Complex of Topoisomerase IV From S. Pneumoniae (pdb code 4z3o). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 4 binding sites of Magnesium where determined in the Quinolone(Moxifloxacin)-Dna Cleavage Complex of Topoisomerase IV From S. Pneumoniae, PDB code: 4z3o:
Jump to Magnesium binding site number: 1; 2; 3; 4;

Magnesium binding site 1 out of 4 in 4z3o

Go back to Magnesium Binding Sites List in 4z3o
Magnesium binding site 1 out of 4 in the Quinolone(Moxifloxacin)-Dna Cleavage Complex of Topoisomerase IV From S. Pneumoniae


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Quinolone(Moxifloxacin)-Dna Cleavage Complex of Topoisomerase IV From S. Pneumoniae within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg1501

b:83.5
occ:1.00
 OD2 A:ASP508 2.8 0.8 1.0
OD2 A:ASP506 2.9 0.2 1.0
OD1 A:ASP508 3.3 0.8 1.0
CG A:ASP508 3.4 0.4 1.0
CG A:ASP506 3.7 0.8 1.0
OP1 G:DT15 3.8 0.7 1.0
CB A:ASP506 4.0 0.9 1.0
C5' G:DT15 4.2 0.9 1.0
OE1 A:GLU433 4.2 0.9 1.0
O3' G:DT15 4.6 0.1 1.0
OD1 A:ASP506 4.7 0.0 1.0
CB A:ASP508 4.8 0.7 1.0
O5' G:DT15 4.9 0.1 1.0
O A:LYS581 4.9 99.9 1.0
P G:DT15 5.0 99.2 1.0

Magnesium binding site 2 out of 4 in 4z3o

Go back to Magnesium Binding Sites List in 4z3o
Magnesium binding site 2 out of 4 in the Quinolone(Moxifloxacin)-Dna Cleavage Complex of Topoisomerase IV From S. Pneumoniae


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Quinolone(Moxifloxacin)-Dna Cleavage Complex of Topoisomerase IV From S. Pneumoniae within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg1502

b:0.9
occ:1.00
 O H:MFX101 2.0 0.5 1.0
O02 H:MFX101 2.0 0.6 1.0
C19 H:MFX101 3.0 0.9 1.0
C20 H:MFX101 3.0 0.2 1.0
C18 H:MFX101 3.3 0.1 1.0
O03 H:MFX101 4.1 0.5 1.0
N6 F:DA1 4.2 0.6 1.0
C14 H:MFX101 4.2 0.3 1.0
O4 G:DT15 4.2 0.8 1.0
CB A:SER1079 4.5 81.0 1.0
C17 H:MFX101 4.6 0.8 1.0
C16 H:MFX101 4.7 0.7 1.0
OD2 A:ASP1083 4.8 84.3 1.0
N6 H:DA5 4.8 0.9 1.0

Magnesium binding site 3 out of 4 in 4z3o

Go back to Magnesium Binding Sites List in 4z3o
Magnesium binding site 3 out of 4 in the Quinolone(Moxifloxacin)-Dna Cleavage Complex of Topoisomerase IV From S. Pneumoniae


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Quinolone(Moxifloxacin)-Dna Cleavage Complex of Topoisomerase IV From S. Pneumoniae within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg1501

b:73.3
occ:1.00
 OD2 B:ASP508 2.5 0.5 1.0
OD2 B:ASP506 2.7 0.9 1.0
OD1 B:ASP508 3.1 0.1 1.0
CG B:ASP508 3.1 0.5 1.0
CG B:ASP506 3.7 0.1 1.0
OP1 E:DT15 3.8 95.7 1.0
CB B:ASP506 3.9 0.3 1.0
OE1 B:GLU433 4.3 0.4 1.0
C5' E:DT15 4.3 80.8 1.0
O B:LYS581 4.5 0.8 1.0
CB B:ASP508 4.6 0.1 1.0
OD1 B:ASP506 4.8 0.8 1.0
O3' E:DT15 4.8 0.3 1.0
O5' E:DT15 4.9 81.4 1.0
CD B:GLU433 5.0 0.9 1.0

Magnesium binding site 4 out of 4 in 4z3o

Go back to Magnesium Binding Sites List in 4z3o
Magnesium binding site 4 out of 4 in the Quinolone(Moxifloxacin)-Dna Cleavage Complex of Topoisomerase IV From S. Pneumoniae


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 4 of Quinolone(Moxifloxacin)-Dna Cleavage Complex of Topoisomerase IV From S. Pneumoniae within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg1502

b:83.2
occ:1.00
 O F:MFX101 2.0 0.4 1.0
O02 F:MFX101 2.0 0.2 1.0
C19 F:MFX101 3.0 0.4 1.0
C20 F:MFX101 3.0 0.0 1.0
C18 F:MFX101 3.4 0.7 1.0
OG B:SER1079 3.9 1.0 1.0
O4 E:DT15 4.0 97.4 1.0
O03 F:MFX101 4.1 0.3 1.0
O6 H:DG1 4.2 0.4 1.0
C14 F:MFX101 4.3 0.2 1.0
CB B:SER1079 4.3 89.3 1.0
C17 F:MFX101 4.6 0.6 1.0
OD2 B:ASP1083 4.8 85.2 1.0
C16 F:MFX101 4.8 0.5 1.0
N6 F:DA5 4.8 0.4 1.0
N4 F:DC4 5.0 0.8 1.0

Reference:

I.Laponogov, D.A.Veselkov, X.-S.Pan, J.Selvarajah, I.M.-T.Crevel, L.M.Fisher, M.R.Sanderson. Structural Studies of the Drug-Stabilized Cleavage Complexes of Topoisomerase IV and Gyrase From Streptococcus Pneumoniae To Be Published.
Page generated: Sat Sep 28 23:36:58 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy