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Atomistry » Magnesium » PDB 4zi2-4zol » 4zo5 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 4zi2-4zol » 4zo5 » |
Magnesium in PDB 4zo5: PDE10 Complexed with 4-Isopropoxy-2-(2-(3-(4-Methoxyphenyl)-4-Oxo-3,4- Dihydroquinazolin-2-Yl)Ethyl)Isoindoline-1,3-DioneEnzymatic activity of PDE10 Complexed with 4-Isopropoxy-2-(2-(3-(4-Methoxyphenyl)-4-Oxo-3,4- Dihydroquinazolin-2-Yl)Ethyl)Isoindoline-1,3-Dione
All present enzymatic activity of PDE10 Complexed with 4-Isopropoxy-2-(2-(3-(4-Methoxyphenyl)-4-Oxo-3,4- Dihydroquinazolin-2-Yl)Ethyl)Isoindoline-1,3-Dione:
3.1.4.17; 3.1.4.35; Protein crystallography data
The structure of PDE10 Complexed with 4-Isopropoxy-2-(2-(3-(4-Methoxyphenyl)-4-Oxo-3,4- Dihydroquinazolin-2-Yl)Ethyl)Isoindoline-1,3-Dione, PDB code: 4zo5
was solved by
Y.Yan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4zo5:
The structure of PDE10 Complexed with 4-Isopropoxy-2-(2-(3-(4-Methoxyphenyl)-4-Oxo-3,4- Dihydroquinazolin-2-Yl)Ethyl)Isoindoline-1,3-Dione also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the PDE10 Complexed with 4-Isopropoxy-2-(2-(3-(4-Methoxyphenyl)-4-Oxo-3,4- Dihydroquinazolin-2-Yl)Ethyl)Isoindoline-1,3-Dione
(pdb code 4zo5). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the PDE10 Complexed with 4-Isopropoxy-2-(2-(3-(4-Methoxyphenyl)-4-Oxo-3,4- Dihydroquinazolin-2-Yl)Ethyl)Isoindoline-1,3-Dione, PDB code: 4zo5: Jump to Magnesium binding site number: 1; 2; Magnesium binding site 1 out of 2 in 4zo5Go back to Magnesium Binding Sites List in 4zo5
Magnesium binding site 1 out
of 2 in the PDE10 Complexed with 4-Isopropoxy-2-(2-(3-(4-Methoxyphenyl)-4-Oxo-3,4- Dihydroquinazolin-2-Yl)Ethyl)Isoindoline-1,3-Dione
Mono view Stereo pair view
Magnesium binding site 2 out of 2 in 4zo5Go back to Magnesium Binding Sites List in 4zo5
Magnesium binding site 2 out
of 2 in the PDE10 Complexed with 4-Isopropoxy-2-(2-(3-(4-Methoxyphenyl)-4-Oxo-3,4- Dihydroquinazolin-2-Yl)Ethyl)Isoindoline-1,3-Dione
Mono view Stereo pair view
Reference:
C.D.Cox,
E.D.Hostetler,
B.A.Flores,
J.L.Evelhoch,
H.Fan,
L.Gantert,
M.Holahan,
W.Eng,
A.Joshi,
G.Mcgaughey,
X.Meng,
M.Purcell,
I.T.Raheem,
K.Riffel,
Y.Yan,
J.J.Renger,
S.M.Smith,
P.J.Coleman.
Discovery of [(11)C]Mk-8193 As A Pet Tracer to Measure Target Engagement of Phosphodiesterase 10A (PDE10A) Inhibitors. Bioorg.Med.Chem.Lett. V. 25 4893 2015.
Page generated: Sun Sep 29 00:05:26 2024
ISSN: ESSN 1464-3405 PubMed: 26077491 DOI: 10.1016/J.BMCL.2015.05.080 |
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