Magnesium »
PDB 5avy-5b8f »
5axq »
Magnesium in PDB 5axq: Crystal Structure of the Catalytic Domain of PDE10A Complexed with Highly Potent and Brain-Penetrant PDE10A Inhibitor with 2-Oxindole Scaffold
Enzymatic activity of Crystal Structure of the Catalytic Domain of PDE10A Complexed with Highly Potent and Brain-Penetrant PDE10A Inhibitor with 2-Oxindole Scaffold
All present enzymatic activity of Crystal Structure of the Catalytic Domain of PDE10A Complexed with Highly Potent and Brain-Penetrant PDE10A Inhibitor with 2-Oxindole Scaffold:
3.1.4.17; 3.1.4.35;
3.1.4.17; 3.1.4.35;
Protein crystallography data
The structure of Crystal Structure of the Catalytic Domain of PDE10A Complexed with Highly Potent and Brain-Penetrant PDE10A Inhibitor with 2-Oxindole Scaffold, PDB code: 5axq
was solved by
H.Oki,
Y.Zama,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 50.00 / 1.77 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 49.685, 81.793, 159.849, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 17.1 / 21.1 |
Other elements in 5axq:
The structure of Crystal Structure of the Catalytic Domain of PDE10A Complexed with Highly Potent and Brain-Penetrant PDE10A Inhibitor with 2-Oxindole Scaffold also contains other interesting chemical elements:
| Fluorine | (F) | 2 atoms |
| Zinc | (Zn) | 2 atoms |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Crystal Structure of the Catalytic Domain of PDE10A Complexed with Highly Potent and Brain-Penetrant PDE10A Inhibitor with 2-Oxindole Scaffold
(pdb code 5axq). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of the Catalytic Domain of PDE10A Complexed with Highly Potent and Brain-Penetrant PDE10A Inhibitor with 2-Oxindole Scaffold, PDB code: 5axq:
Jump to Magnesium binding site number: 1; 2;
In total 2 binding sites of Magnesium where determined in the Crystal Structure of the Catalytic Domain of PDE10A Complexed with Highly Potent and Brain-Penetrant PDE10A Inhibitor with 2-Oxindole Scaffold, PDB code: 5axq:
Jump to Magnesium binding site number: 1; 2;
Magnesium binding site 1 out of 2 in 5axq
Go back to
Magnesium Binding Sites List in 5axq
Magnesium binding site 1 out
of 2 in the Crystal Structure of the Catalytic Domain of PDE10A Complexed with Highly Potent and Brain-Penetrant PDE10A Inhibitor with 2-Oxindole Scaffold
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Crystal Structure of the Catalytic Domain of PDE10A Complexed with Highly Potent and Brain-Penetrant PDE10A Inhibitor with 2-Oxindole Scaffold within 5.0Å range:
|
Magnesium binding site 2 out of 2 in 5axq
Go back to
Magnesium Binding Sites List in 5axq
Magnesium binding site 2 out
of 2 in the Crystal Structure of the Catalytic Domain of PDE10A Complexed with Highly Potent and Brain-Penetrant PDE10A Inhibitor with 2-Oxindole Scaffold
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 2 of Crystal Structure of the Catalytic Domain of PDE10A Complexed with Highly Potent and Brain-Penetrant PDE10A Inhibitor with 2-Oxindole Scaffold within 5.0Å range:
|
Reference:
M.Yoshikawa,
H.Kamisaki,
J.Kunitomo,
H.Oki,
H.Kokubo,
A.Suzuki,
T.Ikemoto,
K.Nakashima,
N.Kamiguchi,
A.Harada,
H.Kimura,
T.Taniguchi.
Design and Synthesis of A Novel 2-Oxindole Scaffold As A Highly Potent and Brain-Penetrant Phosphodiesterase 10A Inhibitor Bioorg.Med.Chem. V. 23 7138 2015.
ISSN: ESSN 1464-3391
PubMed: 26494583
DOI: 10.1016/J.BMC.2015.10.002
Page generated: Sun Sep 29 00:58:16 2024
ISSN: ESSN 1464-3391
PubMed: 26494583
DOI: 10.1016/J.BMC.2015.10.002
Last articles
Zn in 9JYWZn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
