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Magnesium in PDB 5c25: Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 6- ((4-((4-Cyanophenyl)Amino)-1,3,5-Triazin-2-Yl)Amino)-5,7-Dimethyl-2- Naphthonitrile (JLJ639), A Non-Nucleoside InhibitorEnzymatic activity of Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 6- ((4-((4-Cyanophenyl)Amino)-1,3,5-Triazin-2-Yl)Amino)-5,7-Dimethyl-2- Naphthonitrile (JLJ639), A Non-Nucleoside Inhibitor
All present enzymatic activity of Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 6- ((4-((4-Cyanophenyl)Amino)-1,3,5-Triazin-2-Yl)Amino)-5,7-Dimethyl-2- Naphthonitrile (JLJ639), A Non-Nucleoside Inhibitor:
2.7.7.49; 2.7.7.7; 3.1.13.2; 3.1.26.13; 3.4.23.16; Protein crystallography data
The structure of Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 6- ((4-((4-Cyanophenyl)Amino)-1,3,5-Triazin-2-Yl)Amino)-5,7-Dimethyl-2- Naphthonitrile (JLJ639), A Non-Nucleoside Inhibitor, PDB code: 5c25
was solved by
A.H.Chan,
K.M.Frey,
K.S.Anderson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 6- ((4-((4-Cyanophenyl)Amino)-1,3,5-Triazin-2-Yl)Amino)-5,7-Dimethyl-2- Naphthonitrile (JLJ639), A Non-Nucleoside Inhibitor
(pdb code 5c25). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 6- ((4-((4-Cyanophenyl)Amino)-1,3,5-Triazin-2-Yl)Amino)-5,7-Dimethyl-2- Naphthonitrile (JLJ639), A Non-Nucleoside Inhibitor, PDB code: 5c25: Magnesium binding site 1 out of 1 in 5c25Go back to Magnesium Binding Sites List in 5c25
Magnesium binding site 1 out
of 1 in the Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 6- ((4-((4-Cyanophenyl)Amino)-1,3,5-Triazin-2-Yl)Amino)-5,7-Dimethyl-2- Naphthonitrile (JLJ639), A Non-Nucleoside Inhibitor
Mono view Stereo pair view
Reference:
W.G.Lee,
K.M.Frey,
R.Gallardo-Macias,
K.A.Spasov,
A.H.Chan,
K.S.Anderson,
W.L.Jorgensen.
Discovery and Crystallography of Bicyclic Arylaminoazines As Potent Inhibitors of Hiv-1 Reverse Transcriptase. Bioorg.Med.Chem.Lett. V. 25 4824 2015.
Page generated: Mon Dec 14 20:05:11 2020
ISSN: ESSN 1464-3405 PubMed: 26166629 DOI: 10.1016/J.BMCL.2015.06.074 |
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