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Magnesium in PDB 5cg6: Neutron Crystal Structure of Human Farnesyl Pyrophosphate Synthase in Complex with Risedronate and Isopentenyl Pyrophosphate
Enzymatic activity of Neutron Crystal Structure of Human Farnesyl Pyrophosphate Synthase in Complex with Risedronate and Isopentenyl Pyrophosphate
All present enzymatic activity of Neutron Crystal Structure of Human Farnesyl Pyrophosphate Synthase in Complex with Risedronate and Isopentenyl Pyrophosphate:
2.5.1.1; 2.5.1.10;
2.5.1.1; 2.5.1.10;
Protein crystallography data
The structure of Neutron Crystal Structure of Human Farnesyl Pyrophosphate Synthase in Complex with Risedronate and Isopentenyl Pyrophosphate, PDB code: 5cg6
was solved by
T.Yokoyama,
M.Mizuguchi,
A.Ostermann,
K.Kusaka,
N.Niimura,
T.E.Schrader,
I.Tanaka,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | N/A / 1.70 |
| Space group | P 41 21 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 111.627, 111.627, 72.553, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 26 / 28.7 |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Neutron Crystal Structure of Human Farnesyl Pyrophosphate Synthase in Complex with Risedronate and Isopentenyl Pyrophosphate
(pdb code 5cg6). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Neutron Crystal Structure of Human Farnesyl Pyrophosphate Synthase in Complex with Risedronate and Isopentenyl Pyrophosphate, PDB code: 5cg6:
Jump to Magnesium binding site number: 1; 2; 3;
In total 3 binding sites of Magnesium where determined in the Neutron Crystal Structure of Human Farnesyl Pyrophosphate Synthase in Complex with Risedronate and Isopentenyl Pyrophosphate, PDB code: 5cg6:
Jump to Magnesium binding site number: 1; 2; 3;
Magnesium binding site 1 out of 3 in 5cg6
Go back to
Magnesium Binding Sites List in 5cg6
Magnesium binding site 1 out
of 3 in the Neutron Crystal Structure of Human Farnesyl Pyrophosphate Synthase in Complex with Risedronate and Isopentenyl Pyrophosphate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Neutron Crystal Structure of Human Farnesyl Pyrophosphate Synthase in Complex with Risedronate and Isopentenyl Pyrophosphate within 5.0Å range:
|
Magnesium binding site 2 out of 3 in 5cg6
Go back to
Magnesium Binding Sites List in 5cg6
Magnesium binding site 2 out
of 3 in the Neutron Crystal Structure of Human Farnesyl Pyrophosphate Synthase in Complex with Risedronate and Isopentenyl Pyrophosphate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 2 of Neutron Crystal Structure of Human Farnesyl Pyrophosphate Synthase in Complex with Risedronate and Isopentenyl Pyrophosphate within 5.0Å range:
|
Magnesium binding site 3 out of 3 in 5cg6
Go back to
Magnesium Binding Sites List in 5cg6
Magnesium binding site 3 out
of 3 in the Neutron Crystal Structure of Human Farnesyl Pyrophosphate Synthase in Complex with Risedronate and Isopentenyl Pyrophosphate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 3 of Neutron Crystal Structure of Human Farnesyl Pyrophosphate Synthase in Complex with Risedronate and Isopentenyl Pyrophosphate within 5.0Å range:
|
Reference:
T.Yokoyama,
M.Mizuguchi,
A.Ostermann,
K.Kusaka,
N.Niimura,
T.E.Schrader,
I.Tanaka.
Protonation State and Hydration of Bisphosphonate Bound to Farnesyl Pyrophosphate Synthase J.Med.Chem. V. 58 7549 2015.
ISSN: ISSN 0022-2623
PubMed: 26314394
DOI: 10.1021/ACS.JMEDCHEM.5B01147
Page generated: Sun Sep 29 02:05:25 2024
ISSN: ISSN 0022-2623
PubMed: 26314394
DOI: 10.1021/ACS.JMEDCHEM.5B01147
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