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Atomistry » Magnesium » PDB 5dar-5djg » 5dh4 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 5dar-5djg » 5dh4 » |
Magnesium in PDB 5dh4: PDE10 Complexed with 5-Chloro-N-[(2,4-Dimethylthiazol-5-Yl) Methyl]Pyrazolo[1,5-A]Pyrimidin-7-AmineEnzymatic activity of PDE10 Complexed with 5-Chloro-N-[(2,4-Dimethylthiazol-5-Yl) Methyl]Pyrazolo[1,5-A]Pyrimidin-7-Amine
All present enzymatic activity of PDE10 Complexed with 5-Chloro-N-[(2,4-Dimethylthiazol-5-Yl) Methyl]Pyrazolo[1,5-A]Pyrimidin-7-Amine:
3.1.4.17; 3.1.4.35; Protein crystallography data
The structure of PDE10 Complexed with 5-Chloro-N-[(2,4-Dimethylthiazol-5-Yl) Methyl]Pyrazolo[1,5-A]Pyrimidin-7-Amine, PDB code: 5dh4
was solved by
Y.Yan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5dh4:
The structure of PDE10 Complexed with 5-Chloro-N-[(2,4-Dimethylthiazol-5-Yl) Methyl]Pyrazolo[1,5-A]Pyrimidin-7-Amine also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the PDE10 Complexed with 5-Chloro-N-[(2,4-Dimethylthiazol-5-Yl) Methyl]Pyrazolo[1,5-A]Pyrimidin-7-Amine
(pdb code 5dh4). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the PDE10 Complexed with 5-Chloro-N-[(2,4-Dimethylthiazol-5-Yl) Methyl]Pyrazolo[1,5-A]Pyrimidin-7-Amine, PDB code: 5dh4: Jump to Magnesium binding site number: 1; 2; Magnesium binding site 1 out of 2 in 5dh4Go back to Magnesium Binding Sites List in 5dh4
Magnesium binding site 1 out
of 2 in the PDE10 Complexed with 5-Chloro-N-[(2,4-Dimethylthiazol-5-Yl) Methyl]Pyrazolo[1,5-A]Pyrimidin-7-Amine
Mono view Stereo pair view
Magnesium binding site 2 out of 2 in 5dh4Go back to Magnesium Binding Sites List in 5dh4
Magnesium binding site 2 out
of 2 in the PDE10 Complexed with 5-Chloro-N-[(2,4-Dimethylthiazol-5-Yl) Methyl]Pyrazolo[1,5-A]Pyrimidin-7-Amine
Mono view Stereo pair view
Reference:
I.T.Raheem,
J.D.Schreier,
J.Fuerst,
L.Gantert,
E.D.Hostetler,
S.Huszar,
A.Joshi,
M.Kandebo,
S.H.Kim,
J.Li,
B.Ma,
G.Mcgaughey,
S.Sharma,
W.D.Shipe,
J.Uslaner,
G.H.Vandeveer,
Y.Yan,
J.J.Renger,
S.M.Smith,
P.J.Coleman,
C.D.Cox.
Discovery of Pyrazolopyrimidine Phosphodiesterase 10A Inhibitors For the Treatment of Schizophrenia. Bioorg.Med.Chem.Lett. V. 26 126 2016.
Page generated: Sun Sep 29 02:47:04 2024
ISSN: ESSN 1464-3405 PubMed: 26602277 DOI: 10.1016/J.BMCL.2015.11.013 |
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