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Magnesium in PDB 5eg3: Crystal Structure of the Activated Fgf Receptor 2 (FGFR2) Kinase Domain in Complex with the CSH2 Domain of Phospholipase C Gamma (Plcgamma)

Enzymatic activity of Crystal Structure of the Activated Fgf Receptor 2 (FGFR2) Kinase Domain in Complex with the CSH2 Domain of Phospholipase C Gamma (Plcgamma)

All present enzymatic activity of Crystal Structure of the Activated Fgf Receptor 2 (FGFR2) Kinase Domain in Complex with the CSH2 Domain of Phospholipase C Gamma (Plcgamma):
2.7.10.1; 3.1.4.11;

Protein crystallography data

The structure of Crystal Structure of the Activated Fgf Receptor 2 (FGFR2) Kinase Domain in Complex with the CSH2 Domain of Phospholipase C Gamma (Plcgamma), PDB code: 5eg3 was solved by Z.Huang, X.Li, M.Mohammadi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 37.86 / 2.61
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 79.609, 53.231, 127.660, 90.00, 100.11, 90.00
R / Rfree (%) 18.5 / 23.7

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of the Activated Fgf Receptor 2 (FGFR2) Kinase Domain in Complex with the CSH2 Domain of Phospholipase C Gamma (Plcgamma) (pdb code 5eg3). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of the Activated Fgf Receptor 2 (FGFR2) Kinase Domain in Complex with the CSH2 Domain of Phospholipase C Gamma (Plcgamma), PDB code: 5eg3:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 5eg3

Go back to Magnesium Binding Sites List in 5eg3
Magnesium binding site 1 out of 2 in the Crystal Structure of the Activated Fgf Receptor 2 (FGFR2) Kinase Domain in Complex with the CSH2 Domain of Phospholipase C Gamma (Plcgamma)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of the Activated Fgf Receptor 2 (FGFR2) Kinase Domain in Complex with the CSH2 Domain of Phospholipase C Gamma (Plcgamma) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg802

b:37.7
occ:1.00
 MG A:MG803 2.1 28.4 1.0
OD1 A:ASN631 2.5 22.7 1.0
O1A A:ACP801 2.6 23.8 1.0
O A:ARG630 2.9 23.1 1.0
O1B A:ACP801 3.2 21.8 1.0
C5' A:ACP801 3.5 30.1 1.0
C A:ARG630 3.6 22.3 1.0
CG A:ASN631 3.7 22.7 1.0
CG A:ARG630 3.7 21.6 1.0
PA A:ACP801 3.9 25.3 1.0
CB A:ARG630 3.9 22.4 1.0
O5' A:ACP801 4.0 30.3 1.0
OD2 A:ASP644 4.0 29.3 1.0
CD A:ARG630 4.1 21.1 1.0
O3' A:ACP801 4.1 29.1 1.0
C4' A:ACP801 4.2 29.3 1.0
N A:ASN631 4.3 21.8 1.0
CA A:ARG630 4.3 23.0 1.0
CA A:ASN631 4.4 21.8 1.0
ND2 A:ASN631 4.5 23.2 1.0
PB A:ACP801 4.5 50.5 1.0
C3' A:ACP801 4.5 28.1 1.0
O3A A:ACP801 4.6 25.0 1.0
CB A:ASN631 4.7 22.0 1.0
O2B A:ACP801 4.7 51.1 1.0
NE A:ARG630 4.8 21.0 1.0
CG A:ASP644 4.9 29.6 1.0

Magnesium binding site 2 out of 2 in 5eg3

Go back to Magnesium Binding Sites List in 5eg3
Magnesium binding site 2 out of 2 in the Crystal Structure of the Activated Fgf Receptor 2 (FGFR2) Kinase Domain in Complex with the CSH2 Domain of Phospholipase C Gamma (Plcgamma)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of the Activated Fgf Receptor 2 (FGFR2) Kinase Domain in Complex with the CSH2 Domain of Phospholipase C Gamma (Plcgamma) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg803

b:28.4
occ:1.00
 OD2 A:ASP644 2.1 29.3 1.0
MG A:MG802 2.1 37.7 1.0
O1B A:ACP801 2.2 21.8 1.0
OD1 A:ASN631 2.3 22.7 1.0
O1A A:ACP801 2.6 23.8 1.0
CG A:ASN631 3.3 22.7 1.0
CG A:ASP644 3.3 29.6 1.0
ND2 A:ASN631 3.5 23.2 1.0
PB A:ACP801 3.7 50.5 1.0
PA A:ACP801 3.7 25.3 1.0
O3A A:ACP801 3.8 25.0 1.0
O1G A:ACP801 3.9 65.5 1.0
CB A:ASP644 3.9 29.6 1.0
OD1 A:ASP644 4.3 30.0 1.0
CD A:ARG630 4.5 21.1 1.0
O2B A:ACP801 4.5 51.1 1.0
CG A:ARG630 4.5 21.6 1.0
O5' A:ACP801 4.6 30.3 1.0
O A:ARG630 4.6 23.1 1.0
NE A:ARG630 4.6 21.0 1.0
CB A:ASN631 4.6 22.0 1.0
C5' A:ACP801 4.7 30.1 1.0
OD2 A:ASP626 4.7 24.0 1.0
PG A:ACP801 4.8 74.3 1.0
O3G A:ACP801 4.8 74.3 1.0
O2A A:ACP801 4.8 24.2 1.0
C3B A:ACP801 4.9 23.6 1.0

Reference:

Z.Huang, W.M.Marsiglia, U.Basu Roy, N.Rahimi, D.Ilghari, H.Wang, H.Chen, W.Gai, S.Blais, T.A.Neubert, A.Mansukhani, N.J.Traaseth, X.Li, M.Mohammadi. Two Fgf Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase C Gamma. Mol.Cell V. 61 98 2016.
ISSN: ISSN 1097-2765
PubMed: 26687682
DOI: 10.1016/J.MOLCEL.2015.11.010
Page generated: Sun Sep 29 03:41:38 2024

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