Magnesium in PDB 5ew4: Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with SR2+

The structure of Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with SR2+, PDB code: 5ew4 was solved by D.R.Tomchick, D.W.Dodd, K.T.Gagnon, D.R.Corey, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	23.92 / 1.47
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	41.020, 47.615, 58.900, 90.00, 90.00, 90.00
R / Rfree (%)	21.6 / 23.9

The structure of Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with SR2+ also contains other interesting chemical elements:

Strontium	(Sr)	1 atom
Potassium	(K)	9 atoms
Chlorine	(Cl)	1 atom

The binding sites of Magnesium atom in the Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with SR2+ (pdb code 5ew4). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with SR2+, PDB code: 5ew4:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with SR2+


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with SR2+ within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg102 b:39.2 occ:1.00 O2' B:C10 2.1 23.3 1.0 O B:HOH235 2.2 13.1 1.0 H5' B:G11 3.1 18.8 1.0 C2' B:C10 3.2 19.0 1.0 H2' B:C10 3.2 22.8 1.0 H1' B:C10 3.5 20.2 1.0 O2 B:C10 3.7 14.8 1.0 O4' B:G11 3.7 13.7 1.0 C1' B:C10 3.9 16.9 1.0 H4' B:G11 3.9 17.7 1.0 C5' B:G11 4.0 15.7 1.0 C4' B:G11 4.1 14.8 1.0 O B:HOH263 4.5 36.0 1.0 C3' B:C10 4.5 19.9 1.0 H5'' B:G11 4.5 18.8 1.0 C2 B:C10 4.7 14.9 1.0 O3' B:C10 4.7 20.4 1.0 H4' B:C10 4.8 27.9 1.0 N1 B:C10 4.8 16.1 1.0 O5' B:G11 4.9 16.0 1.0 H1' B:G11 4.9 15.1 1.0 C1' B:G11 4.9 12.6 1.0 O4' B:C10 4.9 20.7 1.0

Magnesium binding site 2 out of 2 in the Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with SR2+


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with SR2+ within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg103 b:41.8 occ:1.00 O B:HOH278 2.1 35.0 1.0 OP2 B:C10 2.3 27.2 1.0 H3' B:C9 2.5 31.8 1.0 O B:HOH208 2.9 26.3 1.0 H5 B:C10 3.0 20.0 1.0 O B:HOH276 3.0 32.6 1.0 H6 B:C10 3.4 20.0 1.0 P B:C10 3.4 27.6 1.0 C3' B:C9 3.4 26.5 1.0 O5' B:C10 3.7 26.9 1.0 C5 B:C10 3.7 16.7 1.0 H6 B:C9 3.7 28.0 1.0 C6 B:C9 3.8 23.4 1.0 H2' B:C9 3.9 33.6 1.0 C6 B:C10 3.9 16.6 1.0 H5'' B:C9 3.9 40.7 1.0 O3' B:C9 3.9 26.7 1.0 C5 B:C9 4.1 23.5 1.0 C2' B:C9 4.2 28.0 1.0 K B:K109 4.2 29.2 1.0 N1 B:C9 4.2 24.1 1.0 H5 B:C9 4.3 28.1 1.0 C4' B:C9 4.4 28.3 1.0 C5' B:C9 4.5 33.9 1.0 O B:HOH232 4.5 21.5 1.0 O5' B:C9 4.6 40.6 1.0 C1' B:C9 4.6 26.2 1.0 O4' B:C9 4.7 27.4 1.0 OP1 B:C10 4.8 31.3 1.0 H3' B:C10 4.8 23.9 1.0 C4 B:C9 4.8 19.6 1.0 O B:HOH212 4.8 31.9 1.0 N7 B:G11 4.9 12.2 1.0 C2 B:C9 4.9 24.2 1.0 C5' B:C10 4.9 25.1 1.0 C4 B:C10 4.9 16.7 1.0 H41 B:C10 5.0 19.9 1.0

D.W.Dodd, D.R.Tomchick, D.R.Corey, K.T.Gagnon. Pathogenic C9ORF72 Antisense Repeat Rna Forms A Double Helix with Tandem C:C Mismatches. Biochemistry V. 55 1283 2016.
ISSN: ISSN 0006-2960
PubMed: 26878348
DOI: 10.1021/ACS.BIOCHEM.6B00136