Magnesium in PDB 5fwk: Atomic Cryoem Structure of HSP90-CDC37-CDK4 Complex

The binding sites of Magnesium atom in the Atomic Cryoem Structure of HSP90-CDC37-CDK4 Complex (pdb code 5fwk). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Atomic Cryoem Structure of HSP90-CDC37-CDK4 Complex, PDB code: 5fwk:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Atomic Cryoem Structure of HSP90-CDC37-CDK4 Complex


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Atomic Cryoem Structure of HSP90-CDC37-CDK4 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg726 b:53.2 occ:1.00 OD1 A:ASN46 1.2 51.7 1.0 O2A A:ATP725 2.0 46.0 1.0 O2B A:ATP725 2.0 50.9 1.0 CG A:ASN46 2.2 50.7 1.0 O2G A:ATP725 2.7 42.1 1.0 HD22 A:ASN46 2.7 57.5 1.0 ND2 A:ASN46 2.8 47.9 1.0 PA A:ATP725 3.2 48.2 1.0 HA A:ASN46 3.3 59.2 1.0 PB A:ATP725 3.4 53.2 1.0 O5' A:ATP725 3.5 44.3 1.0 CB A:ASN46 3.5 49.5 1.0 HD21 A:ASN46 3.7 57.5 1.0 CA A:ASN46 3.8 49.3 1.0 O3A A:ATP725 3.9 44.0 1.0 H A:ASN46 3.9 59.0 1.0 PG A:ATP725 3.9 36.5 1.0 N A:ASN46 4.0 49.2 1.0 O A:GLU42 4.1 55.9 1.0 O3B A:ATP725 4.1 45.2 1.0 HB3 A:ASN46 4.1 59.4 1.0 HB2 A:SER45 4.1 57.0 1.0 HB2 A:ASN46 4.2 59.4 1.0 O1A A:ATP725 4.4 50.8 1.0 OD2 A:ASP49 4.5 63.0 1.0 C5' A:ATP725 4.5 44.8 1.0 O1B A:ATP725 4.6 56.2 1.0 OE1 A:GLU42 4.6 56.5 1.0 HB3 A:SER45 4.6 57.0 1.0 C A:SER45 4.7 50.4 1.0 O1G A:ATP725 4.7 46.0 1.0 HB3 A:GLU42 4.8 51.5 1.0 CB A:SER45 4.8 47.5 1.0 HA3 A:GLY132 4.9 54.9 1.0

Magnesium binding site 2 out of 2 in the Atomic Cryoem Structure of HSP90-CDC37-CDK4 Complex


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Atomic Cryoem Structure of HSP90-CDC37-CDK4 Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg726 b:51.7 occ:1.00 OD1 B:ASN46 1.3 47.5 1.0 O2A B:ATP725 2.0 43.1 1.0 O2B B:ATP725 2.0 41.6 1.0 CG B:ASN46 2.1 40.9 1.0 O1B B:ATP725 2.5 43.0 1.0 HD22 B:ASN46 2.5 50.2 1.0 PB B:ATP725 2.5 42.1 1.0 ND2 B:ASN46 2.7 41.9 1.0 PA B:ATP725 3.3 47.0 1.0 HA B:ASN46 3.4 53.1 1.0 CB B:ASN46 3.4 38.3 1.0 O3A B:ATP725 3.5 44.0 1.0 O2G B:ATP725 3.5 39.1 1.0 HD21 B:ASN46 3.5 50.2 1.0 HB3 B:ASN46 3.7 45.9 1.0 CA B:ASN46 3.9 44.2 1.0 O3B B:ATP725 3.9 45.9 1.0 HA3 B:GLY127 4.1 59.8 1.0 O5' B:ATP725 4.2 48.4 1.0 OD2 B:ASP49 4.2 58.7 1.0 HG B:SER108 4.2 68.0 1.0 HB2 B:ASN46 4.2 45.9 1.0 HG1 B:THR110 4.3 71.8 1.0 N B:ASN46 4.3 46.8 1.0 H B:ASN46 4.4 56.2 1.0 PG B:ATP725 4.4 39.0 1.0 O1A B:ATP725 4.5 47.2 1.0 HA2 B:GLY127 4.6 59.8 1.0 O B:GLU42 4.7 52.8 1.0 O B:ILE126 4.8 58.2 1.0 HB2 B:SER45 4.8 53.0 1.0 CA B:GLY127 4.9 49.8 1.0

K.A.Verba, R.Y.Wang, A.Arakawa, Y.Liu, M.Shirouzu, S.Yokoyama, D.A.Agard. Atomic Structure of HSP90-CDC37-CDK4 Reveals That HSP90 Traps and Stabilizes An Unfolded Kinase. Science V. 352 1542 2016.
ISSN: ISSN 0036-8075
PubMed: 27339980
DOI: 10.1126/SCIENCE.AAF5023