Magnesium in PDB 5hze: MEK1 Adopts Dfg-Out Conformation When Bound to An Analog of E6201.

All present enzymatic activity of MEK1 Adopts Dfg-Out Conformation When Bound to An Analog of E6201.:
2.7.12.2;

The structure of MEK1 Adopts Dfg-Out Conformation When Bound to An Analog of E6201., PDB code: 5hze was solved by N.A.Larsen, K.Bloudoff, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.69 / 2.40
Space group	P 61 2 2
Cell size a, b, c (Å), α, β, γ (°)	77.118, 77.118, 222.064, 90.00, 90.00, 120.00
R / Rfree (%)	20.1 / 28.7

The binding sites of Magnesium atom in the MEK1 Adopts Dfg-Out Conformation When Bound to An Analog of E6201. (pdb code 5hze). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the MEK1 Adopts Dfg-Out Conformation When Bound to An Analog of E6201., PDB code: 5hze:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the MEK1 Adopts Dfg-Out Conformation When Bound to An Analog of E6201.


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of MEK1 Adopts Dfg-Out Conformation When Bound to An Analog of E6201. within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg402 b:53.8 occ:1.00 OD2 A:ASP66 1.7 97.9 1.0 CG A:ASP66 2.9 68.5 1.0 OD1 A:ASP66 3.5 68.4 1.0 CB A:ASP66 4.0 65.9 1.0 MG A:MG403 4.1 50.5 0.5

Magnesium binding site 2 out of 2 in the MEK1 Adopts Dfg-Out Conformation When Bound to An Analog of E6201.


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of MEK1 Adopts Dfg-Out Conformation When Bound to An Analog of E6201. within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg403 b:50.5 occ:0.50 OD1 A:ASP66 2.0 68.4 1.0 CG A:ASP66 3.1 68.5 1.0 OD2 A:ASP65 3.5 73.5 1.0 OD2 A:ASP66 3.5 97.9 1.0 CG A:ASP65 3.8 73.3 1.0 CB A:ASP65 3.9 61.0 1.0 OD2 A:ASP136 4.1 96.7 1.0 MG A:MG402 4.1 53.8 1.0 CB A:ASP66 4.4 65.9 1.0 N A:ASP66 4.5 59.4 1.0 OD1 A:ASP65 4.5 64.8 1.0 OG A:SER135 4.6 73.0 1.0 CA A:ASP66 4.7 63.7 1.0 C A:ASP65 4.9 60.0 1.0

N.A.Larsen, K.Bloudoff, V.Subramanian, K.Nomoto, J.Wang. MEK1 Adopts Dfg-Out Conformation When Bound to An Analog of E6201. To Be Published.