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Magnesium in PDB 5j2q: Hiv-1 Reverse Transcriptase in Complex with Dna That Has Incorporated A Mismatched Efda-Mp at the N-(Pre-Translocation) Site

Protein crystallography data

The structure of Hiv-1 Reverse Transcriptase in Complex with Dna That Has Incorporated A Mismatched Efda-Mp at the N-(Pre-Translocation) Site, PDB code: 5j2q was solved by Z.L.Salie, K.A.Kirby, S.G.Sarafianos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 64.33 / 2.79
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 165.557, 170.512, 102.235, 90.00, 90.00, 90.00
R / Rfree (%) 21.2 / 25.2

Other elements in 5j2q:

The structure of Hiv-1 Reverse Transcriptase in Complex with Dna That Has Incorporated A Mismatched Efda-Mp at the N-(Pre-Translocation) Site also contains other interesting chemical elements:

Fluorine (F) 2 atoms

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Hiv-1 Reverse Transcriptase in Complex with Dna That Has Incorporated A Mismatched Efda-Mp at the N-(Pre-Translocation) Site (pdb code 5j2q). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Hiv-1 Reverse Transcriptase in Complex with Dna That Has Incorporated A Mismatched Efda-Mp at the N-(Pre-Translocation) Site, PDB code: 5j2q:

Magnesium binding site 1 out of 1 in 5j2q

Go back to Magnesium Binding Sites List in 5j2q
Magnesium binding site 1 out of 1 in the Hiv-1 Reverse Transcriptase in Complex with Dna That Has Incorporated A Mismatched Efda-Mp at the N-(Pre-Translocation) Site


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Hiv-1 Reverse Transcriptase in Complex with Dna That Has Incorporated A Mismatched Efda-Mp at the N-(Pre-Translocation) Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg601

b:0.7
occ:1.00
O A:HOH702 2.1 72.9 1.0
O A:HOH701 2.1 54.2 1.0
OD2 A:ASP498 2.1 77.8 1.0
OE2 A:GLU478 2.1 61.1 1.0
OD1 A:ASP443 2.1 53.9 1.0
OD1 A:ASP498 2.1 68.9 1.0
CG A:ASP498 2.3 55.1 1.0
CD A:GLU478 3.0 60.9 1.0
CG A:ASP443 3.2 52.2 1.0
OE1 A:GLU478 3.3 78.5 1.0
CB A:ASP498 3.8 47.4 1.0
O A:GLY444 3.8 64.9 1.0
OD2 A:ASP443 3.9 58.6 1.0
N A:GLY444 4.2 54.7 1.0
CB A:ASP443 4.3 55.5 1.0
O A:ASP498 4.3 60.6 1.0
C A:ASP498 4.4 48.5 1.0
CG A:GLU478 4.4 41.6 1.0
CA A:ASP443 4.5 52.4 1.0
CA A:ASP498 4.5 49.1 1.0
CB A:ALA538 4.7 36.5 1.0
N A:ASP498 4.8 44.1 1.0
C A:GLY444 4.8 57.7 1.0
N A:SER499 4.9 34.1 1.0
C A:ASP443 4.9 47.3 1.0
OP1 T:DC723 4.9 84.7 1.0

Reference:

Z.L.Salie, K.A.Kirby, E.Michailidis, B.Marchand, K.Singh, L.C.Rohan, E.N.Kodama, H.Mitsuya, M.A.Parniak, S.G.Sarafianos. Structural Basis of Hiv Inhibition By Translocation-Defective Rt Inhibitor 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine (Efda). Proc.Natl.Acad.Sci.Usa V. 113 9274 2016.
ISSN: ESSN 1091-6490
PubMed: 27489345
DOI: 10.1073/PNAS.1605223113
Page generated: Sun Sep 29 17:35:24 2024

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