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Magnesium in PDB 5jad: Compound Binding to Human Lipoprotein-Associated Phospholipase A2 (Lp- PLA2)Discovered Through Fragment ScreeningEnzymatic activity of Compound Binding to Human Lipoprotein-Associated Phospholipase A2 (Lp- PLA2)Discovered Through Fragment Screening
All present enzymatic activity of Compound Binding to Human Lipoprotein-Associated Phospholipase A2 (Lp- PLA2)Discovered Through Fragment Screening:
3.1.1.47; Protein crystallography data
The structure of Compound Binding to Human Lipoprotein-Associated Phospholipase A2 (Lp- PLA2)Discovered Through Fragment Screening, PDB code: 5jad
was solved by
P.J.Day,
A.J.-A.Woolford,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5jad:
The structure of Compound Binding to Human Lipoprotein-Associated Phospholipase A2 (Lp- PLA2)Discovered Through Fragment Screening also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Compound Binding to Human Lipoprotein-Associated Phospholipase A2 (Lp- PLA2)Discovered Through Fragment Screening
(pdb code 5jad). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Compound Binding to Human Lipoprotein-Associated Phospholipase A2 (Lp- PLA2)Discovered Through Fragment Screening, PDB code: 5jad: Magnesium binding site 1 out of 1 in 5jadGo back to Magnesium Binding Sites List in 5jad
Magnesium binding site 1 out
of 1 in the Compound Binding to Human Lipoprotein-Associated Phospholipase A2 (Lp- PLA2)Discovered Through Fragment Screening
Mono view Stereo pair view
Reference:
A.J.Woolford,
J.E.Pero,
S.Aravapalli,
V.Berdini,
J.E.Coyle,
P.J.Day,
A.M.Dodson,
P.Grondin,
F.P.Holding,
L.Y.Lee,
P.Li,
E.S.Manas,
J.Marino,
A.C.Martin,
B.W.Mccleland,
R.L.Mcmenamin,
C.W.Murray,
C.E.Neipp,
L.W.Page,
V.K.Patel,
F.Potvain,
S.Rich,
R.A.Rivero,
K.Smith,
D.O.Somers,
L.Trottet,
R.Velagaleti,
G.Williams,
R.Xie.
Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered Through X-Ray Fragment Screening. J.Med.Chem. V. 59 5356 2016.
Page generated: Mon Dec 14 20:33:05 2020
ISSN: ISSN 0022-2623 PubMed: 27167608 DOI: 10.1021/ACS.JMEDCHEM.6B00212 |
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