Magnesium in PDB 5js2: Human Argonaute-2 Bound to A Modified Sirna

The structure of Human Argonaute-2 Bound to A Modified Sirna, PDB code: 5js2 was solved by N.T.Schirle, I.J.Macrae, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.98 / 2.95
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	63.102, 107.552, 68.893, 90.00, 107.39, 90.00
R / Rfree (%)	22.2 / 26.1

The structure of Human Argonaute-2 Bound to A Modified Sirna also contains other interesting chemical elements:

Fluorine

(F)

3 atoms

The binding sites of Magnesium atom in the Human Argonaute-2 Bound to A Modified Sirna (pdb code 5js2). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Human Argonaute-2 Bound to A Modified Sirna, PDB code: 5js2:

Magnesium binding site 1 out of 1 in the Human Argonaute-2 Bound to A Modified Sirna


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Human Argonaute-2 Bound to A Modified Sirna within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg904 b:68.2 occ:1.00 OD1 A:ASP597 2.1 67.2 1.0 OD2 A:ASP597 2.1 61.0 1.0 O A:VAL598 2.1 72.5 1.0 CG A:ASP597 2.3 56.9 1.0 C A:VAL598 3.3 58.4 1.0 N A:VAL598 3.6 54.5 1.0 CB A:ASP597 3.7 46.1 1.0 CA A:VAL598 4.0 56.3 1.0 O A:ASP669 4.2 59.0 1.0 C A:ASP597 4.3 49.6 1.0 CA A:ASP597 4.3 46.6 1.0 N A:THR599 4.4 54.3 1.0 CG A:ASP669 4.5 65.9 1.0 C A:ASP669 4.5 59.0 1.0 CB A:ASP669 4.6 54.8 1.0 CA A:GLY670 4.6 62.9 1.0 OD1 A:ASP669 4.7 83.3 1.0 CB A:VAL598 4.7 56.6 1.0 CA A:THR599 4.7 58.2 1.0 OD2 A:ASP669 4.8 56.9 1.0 N A:GLY670 4.8 63.3 1.0 OG1 A:THR599 4.9 57.7 1.0

N.T.Schirle, G.A.Kinberger, H.F.Murray, W.F.Lima, T.P.Prakash, I.J.Macrae. Structural Analysis of Human Argonaute-2 Bound to A Modified Sirna Guide. J.Am.Chem.Soc. V. 138 8694 2016.
ISSN: ESSN 1520-5126
PubMed: 27380263
DOI: 10.1021/JACS.6B04454