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Magnesium in PDB 5l0q: Crystal Structure of the Complex Between ADAM10 D+C Domain and A Conformation Specific Mab 8C7.

Enzymatic activity of Crystal Structure of the Complex Between ADAM10 D+C Domain and A Conformation Specific Mab 8C7.

All present enzymatic activity of Crystal Structure of the Complex Between ADAM10 D+C Domain and A Conformation Specific Mab 8C7.:
3.4.24.81;

Protein crystallography data

The structure of Crystal Structure of the Complex Between ADAM10 D+C Domain and A Conformation Specific Mab 8C7., PDB code: 5l0q was solved by K.Xu, N.Saha, D.B.Nikolov, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 125.26 / 2.76
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 53.326, 141.679, 268.080, 90.00, 90.00, 90.00
R / Rfree (%) 20.3 / 25.1

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of the Complex Between ADAM10 D+C Domain and A Conformation Specific Mab 8C7. (pdb code 5l0q). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of the Complex Between ADAM10 D+C Domain and A Conformation Specific Mab 8C7., PDB code: 5l0q:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 5l0q

Go back to Magnesium Binding Sites List in 5l0q
Magnesium binding site 1 out of 2 in the Crystal Structure of the Complex Between ADAM10 D+C Domain and A Conformation Specific Mab 8C7.


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of the Complex Between ADAM10 D+C Domain and A Conformation Specific Mab 8C7. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg705

b:28.5
occ:1.00
O A:ILE459 2.5 41.5 1.0
OE2 A:GLU469 2.7 38.0 1.0
OD2 A:ASP472 2.7 37.6 1.0
O A:MET464 2.7 41.0 1.0
OE2 A:GLU466 2.7 37.1 1.0
OD1 A:ASN462 2.7 38.7 1.0
OE1 A:GLU469 2.7 45.8 1.0
CD A:GLU469 3.0 44.7 1.0
C A:ILE459 3.4 38.7 1.0
CA A:CYS460 3.6 38.8 1.0
CD A:GLU466 3.7 42.9 1.0
CG A:ASP472 3.8 37.7 1.0
CG A:ASN462 3.8 37.1 1.0
C A:MET464 3.9 36.5 1.0
N A:CYS460 3.9 38.5 1.0
O A:ASN462 4.0 38.7 1.0
N A:ILE459 4.1 40.0 1.0
ND2 A:ASN462 4.2 38.1 1.0
CB A:GLU466 4.2 44.0 1.0
N A:GLY461 4.3 32.7 1.0
CB A:ASP472 4.3 33.0 1.0
CG A:GLU469 4.3 48.1 1.0
O A:HOH817 4.4 36.7 1.0
OE1 A:GLU466 4.4 44.5 1.0
N A:GLU466 4.4 38.8 1.0
CA A:ILE459 4.5 35.1 1.0
CG A:GLU466 4.5 42.9 1.0
C A:CYS460 4.5 34.8 1.0
N A:ASN462 4.6 40.5 1.0
CB A:CYS460 4.6 42.2 1.0
CA A:VAL465 4.6 36.0 1.0
OD1 A:ASP472 4.7 39.0 1.0
N A:VAL465 4.7 31.4 1.0
C A:VAL465 4.7 38.8 1.0
N A:MET464 4.7 30.8 1.0
CA A:MET464 4.8 34.1 1.0
C A:ASN462 4.9 39.5 1.0
CA A:GLU466 5.0 42.2 1.0

Magnesium binding site 2 out of 2 in 5l0q

Go back to Magnesium Binding Sites List in 5l0q
Magnesium binding site 2 out of 2 in the Crystal Structure of the Complex Between ADAM10 D+C Domain and A Conformation Specific Mab 8C7.


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of the Complex Between ADAM10 D+C Domain and A Conformation Specific Mab 8C7. within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Mg704

b:33.9
occ:1.00
OE2 D:GLU469 1.9 38.1 1.0
OD2 D:ASP472 2.0 39.5 1.0
OE1 D:GLU466 2.3 50.1 1.0
O D:MET464 2.4 45.2 1.0
O D:ILE459 2.4 41.3 1.0
OD1 D:ASN462 2.6 47.2 1.0
CD D:GLU469 2.9 43.4 1.0
CG D:ASP472 3.1 40.3 1.0
OE1 D:GLU469 3.4 49.2 1.0
CD D:GLU466 3.4 51.0 1.0
CG D:ASN462 3.5 48.9 1.0
C D:ILE459 3.6 41.3 1.0
C D:MET464 3.6 48.1 1.0
CB D:ASP472 3.8 39.0 1.0
ND2 D:ASN462 3.8 47.8 1.0
CA D:GLY461 4.0 39.4 1.0
N D:ASN462 4.1 36.2 1.0
OD1 D:ASP472 4.1 40.1 1.0
OE2 D:GLU466 4.2 49.9 1.0
CG D:GLU469 4.2 45.6 1.0
N D:MET464 4.2 43.4 1.0
N D:ILE459 4.2 45.9 1.0
CA D:CYS460 4.3 42.9 1.0
CG D:GLU466 4.3 47.6 1.0
N D:CYS460 4.4 44.4 1.0
CB D:GLU466 4.4 46.5 1.0
N D:GLU466 4.4 40.1 1.0
CA D:MET464 4.5 47.0 1.0
N D:VAL465 4.5 44.6 1.0
CA D:VAL465 4.5 41.1 1.0
CA D:ILE459 4.6 41.6 1.0
C D:GLY461 4.7 43.4 1.0
N D:GLY463 4.7 45.5 1.0
C D:VAL465 4.8 41.0 1.0
CB D:ASN462 4.8 47.3 1.0
CB D:MET464 4.9 48.2 1.0
CA D:ASN462 4.9 38.0 1.0

Reference:

L.Atapattu, N.Saha, C.Chheang, M.F.Eissman, K.Xu, M.E.Vail, L.Hii, C.Llerena, Z.Liu, K.Horvay, H.E.Abud, U.Kusebauch, R.L.Moritz, B.S.Ding, Z.Cao, S.Rafii, M.Ernst, A.M.Scott, D.B.Nikolov, M.Lackmann, P.W.Janes. An Activated Form of ADAM10 Is Tumor Selective and Regulates Cancer Stem-Like Cells and Tumor Growth. J.Exp.Med. V. 213 1741 2016.
ISSN: ESSN 1540-9538
PubMed: 27503072
DOI: 10.1084/JEM.20151095
Page generated: Mon Dec 14 20:38:39 2020

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