Magnesium in PDB 5ofa: Crystal Structure of Human MORC2 (Residues 1-603) with Spinal Muscular Atrophy Mutation T424R

The structure of Crystal Structure of Human MORC2 (Residues 1-603) with Spinal Muscular Atrophy Mutation T424R, PDB code: 5ofa was solved by C.H.Douse, Y.Liu, Y.Modis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	80.75 / 2.57
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	69.610, 125.730, 81.530, 90.00, 97.91, 90.00
R / Rfree (%)	21.1 / 23.9

The structure of Crystal Structure of Human MORC2 (Residues 1-603) with Spinal Muscular Atrophy Mutation T424R also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Magnesium atom in the Crystal Structure of Human MORC2 (Residues 1-603) with Spinal Muscular Atrophy Mutation T424R (pdb code 5ofa). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of Human MORC2 (Residues 1-603) with Spinal Muscular Atrophy Mutation T424R, PDB code: 5ofa:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Crystal Structure of Human MORC2 (Residues 1-603) with Spinal Muscular Atrophy Mutation T424R


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Human MORC2 (Residues 1-603) with Spinal Muscular Atrophy Mutation T424R within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg703 b:49.7 occ:1.00 O1G B:ANP702 1.9 33.7 1.0 OD1 B:ASN39 2.0 41.3 1.0 O B:HOH806 2.2 37.7 1.0 O2B B:ANP702 2.3 46.5 1.0 O2A B:ANP702 2.3 37.5 1.0 CG B:ASN39 3.1 43.5 1.0 PB B:ANP702 3.3 44.2 1.0 PG B:ANP702 3.3 41.4 1.0 N3B B:ANP702 3.5 39.8 1.0 ND2 B:ASN39 3.5 47.9 1.0 PA B:ANP702 3.6 46.4 1.0 O3A B:ANP702 3.7 39.9 1.0 NZ B:LYS89 3.8 66.5 1.0 OE2 B:GLU35 4.0 60.8 1.0 O3G B:ANP702 4.2 34.3 1.0 O B:GLU35 4.2 45.4 1.0 CA B:GLY98 4.2 61.3 1.0 CB B:ASN39 4.4 42.7 1.0 O5' B:ANP702 4.4 38.9 1.0 O2G B:ANP702 4.4 38.7 1.0 CA B:ASN39 4.6 46.0 1.0 N B:ASN39 4.6 47.6 1.0 OD2 B:ASP42 4.6 53.9 1.0 O1B B:ANP702 4.7 58.8 1.0 CA B:GLY103 4.7 48.7 1.0 CB B:ASP38 4.8 49.7 1.0 N B:GLY98 4.9 59.7 1.0 N B:GLY103 4.9 51.9 1.0 O1A B:ANP702 4.9 43.1 1.0 N B:LEU104 5.0 45.1 1.0

Magnesium binding site 2 out of 2 in the Crystal Structure of Human MORC2 (Residues 1-603) with Spinal Muscular Atrophy Mutation T424R


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of Human MORC2 (Residues 1-603) with Spinal Muscular Atrophy Mutation T424R within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg703 b:49.5 occ:1.00 O2B A:ANP702 1.8 41.4 1.0 O2A A:ANP702 2.0 46.7 1.0 O2G A:ANP702 2.0 44.4 1.0 O A:HOH808 2.0 36.5 1.0 OD1 A:ASN39 2.1 61.4 1.0 O A:HOH810 2.3 58.9 1.0 PB A:ANP702 2.9 50.6 1.0 CG A:ASN39 3.1 63.9 1.0 PA A:ANP702 3.1 62.6 1.0 O3A A:ANP702 3.3 50.4 1.0 PG A:ANP702 3.3 55.0 1.0 ND2 A:ASN39 3.4 64.6 1.0 N3B A:ANP702 3.5 47.9 1.0 NZ A:LYS89 3.8 0.7 1.0 O5' A:ANP702 3.8 66.5 1.0 OE1 A:GLU35 4.2 81.1 1.0 O1G A:ANP702 4.3 52.2 1.0 O3G A:ANP702 4.3 55.0 1.0 O1B A:ANP702 4.4 43.6 1.0 O A:GLU35 4.4 63.6 1.0 CA A:GLY103 4.4 66.0 1.0 O1A A:ANP702 4.4 63.7 1.0 CB A:ASN39 4.5 61.2 1.0 N A:GLY103 4.5 66.5 1.0 CA A:GLY98 4.5 69.6 1.0 N A:LEU104 4.6 63.5 1.0 CA A:ASN39 4.8 65.3 1.0 C A:GLY103 4.9 66.6 1.0 N A:ASN39 4.9 68.4 1.0

C.H.Douse, S.Bloor, Y.Liu, M.Shamin, I.A.Tchasovnikarova, R.T.Timms, P.J.Lehner, Y.Modis. Neuropathic MORC2 Mutations Perturb Ghkl Atpase Dimerization Dynamics and Epigenetic Silencing By Multiple Structural Mechanisms. Nat Commun V. 9 651 2018.
ISSN: ESSN 2041-1723
PubMed: 29440755
DOI: 10.1038/S41467-018-03045-X