Magnesium in PDB 5td9: Structure of Human Enolase 2

All present enzymatic activity of Structure of Human Enolase 2:
4.2.1.11;

The structure of Structure of Human Enolase 2, PDB code: 5td9 was solved by P.G.Leonard, F.L.Muller, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.51 / 2.32
Space group	P 2 21 21
Cell size a, b, c (Å), α, β, γ (°)	68.319, 112.868, 119.922, 90.00, 90.00, 90.00
R / Rfree (%)	20 / 24.5

The structure of Structure of Human Enolase 2 also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Magnesium atom in the Structure of Human Enolase 2 (pdb code 5td9). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Structure of Human Enolase 2, PDB code: 5td9:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Structure of Human Enolase 2


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structure of Human Enolase 2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg501 b:75.0 occ:1.00 OE1 A:GLU293 2.1 90.8 1.0 OD1 A:ASP318 2.1 61.4 1.0 OD1 A:ASP245 2.1 87.8 1.0 O A:HOH636 2.2 62.2 1.0 O A:HOH607 2.2 72.9 1.0 O A:HOH608 2.2 53.2 1.0 CG A:ASP245 3.0 85.4 1.0 CG A:ASP318 3.2 63.7 1.0 OD2 A:ASP245 3.2 90.2 1.0 CD A:GLU293 3.3 83.5 1.0 CB A:ASP318 3.7 58.7 1.0 NZ A:LYS394 3.9 42.4 1.0 OE2 A:GLU293 4.0 83.8 1.0 NE2 A:GLN166 4.1 67.0 1.0 OD2 A:ASP318 4.2 63.5 1.0 CG A:GLU293 4.3 78.2 1.0 OE2 A:GLU167 4.4 71.9 1.0 CD2 A:LEU341 4.4 44.8 1.0 CB A:ASP245 4.4 76.8 1.0 OD2 A:ASP294 4.5 67.0 1.0 NZ A:LYS343 4.6 49.4 1.0

Magnesium binding site 2 out of 2 in the Structure of Human Enolase 2


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Structure of Human Enolase 2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg501 b:47.0 occ:1.00 OE2 B:GLU293 2.0 63.5 1.0 OD1 B:ASP318 2.1 31.8 1.0 O B:HOH605 2.1 51.7 1.0 OD2 B:ASP245 2.2 35.4 1.0 O B:HOH604 2.4 35.9 1.0 O B:HOH638 2.4 38.0 1.0 CG B:ASP245 3.2 35.8 1.0 CD B:GLU293 3.2 61.3 1.0 CG B:ASP318 3.3 38.4 1.0 OD1 B:ASP245 3.6 43.7 1.0 NE2 B:GLN166 3.8 45.9 1.0 NZ B:LYS394 3.9 35.7 1.0 OE1 B:GLU293 4.0 62.6 1.0 CB B:ASP318 4.0 36.1 1.0 OE1 B:GLU167 4.1 50.9 1.0 OD2 B:ASP318 4.2 35.6 1.0 CG B:GLU293 4.3 55.5 1.0 NZ B:LYS343 4.4 36.2 1.0 CB B:ASP245 4.5 31.3 1.0 CD2 B:LEU341 4.6 28.9 1.0 OD2 B:ASP294 4.7 50.2 1.0 CD B:GLU167 4.8 50.2 1.0 CE B:LYS394 4.9 36.6 1.0

Y.H.Lin, N.Satani, N.Hammoudi, F.Felini, P.G.Leonard, D.Maxwell, Z.Peng, T.M.Link, G.R.Lee, A.Bosajou, D.Sun, J.R.Marszalek, Y.T.Sun, J.Mcmurray, P.J.Mandal, R.Zielinski, W.Priebe, M.E.Difrancesco, B.Czako, Y.A.Wang, W.Bornmann, R.A.Depinho, F.L.Muller. Pomhex, A Cell-Permeable Enolase Inhibitor For Collateral Lethality Targeting of ENO1-Deleted Glioblastoma To Be Published.