Magnesium in PDB 5tfb: Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp

Enzymatic activity of Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp

All present enzymatic activity of Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp:
3.6.3.49;

Protein crystallography data

The structure of Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp, PDB code: 5tfb was solved by C.Wang, A.A.Aleksandrov, Z.Yang, F.Forouhar, E.Proctor, P.Kota, J.An, A.Kaplan, N.Khazanov, G.Boel, B.R.Stockwell, H.Senderowitz, N.V.Dokholyan, J.R.Riordan, C.G.Brouillette, J.F.Hunt, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.29 / 1.87
Space group P 43
Cell size a, b, c (Å), α, β, γ (°) 40.293, 40.293, 141.636, 90.00, 90.00, 90.00
R / Rfree (%) 15 / 19.9

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp (pdb code 5tfb). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp, PDB code: 5tfb:

Magnesium binding site 1 out of 1 in 5tfb

Go back to Magnesium Binding Sites List in 5tfb
Magnesium binding site 1 out of 1 in the Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg701

b:10.6
occ:1.00
NE2 A:GLN493 1.9 47.1 1.0
O1C A:MGP702 1.9 14.9 1.0
OG1 A:THR465 2.0 10.2 1.0
O2B A:MGP702 2.1 10.8 1.0
O A:HOH806 2.2 13.1 1.0
O A:HOH825 2.2 9.7 1.0
OE1 A:GLN493 2.2 28.6 1.0
CD A:GLN493 2.4 5.9 1.0
CB A:THR465 3.2 11.2 1.0
PC A:MGP702 3.2 14.4 1.0
PB A:MGP702 3.3 10.9 1.0
O3B A:MGP702 3.6 12.8 1.0
OD2 A:ASP572 3.9 16.4 1.0
O2C A:MGP702 4.0 13.5 1.0
CG A:GLN493 4.0 27.1 1.0
N A:THR465 4.0 9.3 1.0
O2A A:MGP702 4.0 15.0 1.0
O A:HOH882 4.1 16.1 1.0
OD1 A:ASP572 4.1 13.5 1.0
CA A:THR465 4.1 10.7 1.0
CG2 A:THR465 4.2 13.1 1.0
O3A A:MGP702 4.4 12.4 1.0
CG A:ASP572 4.4 15.8 1.0
O3C A:MGP702 4.4 12.3 1.0
O1B A:MGP702 4.4 11.5 1.0
O A:HOH975 4.5 34.6 1.0
PA A:MGP702 4.7 13.5 1.0
O A:HOH827 4.7 15.7 1.0
O A:HOH990 4.7 36.5 1.0
CB A:GLN493 4.8 13.9 1.0

Reference:

C.Wang, A.A.Aleksandrov, Z.Yang, F.Forouhar, E.Proctor, P.Kota, J.An, A.Kaplan, N.Khazanov, G.Boel, B.R.Stockwell, H.Senderowitz, N.V.Dokholyan, J.R.Riordan, C.G.Brouillette, J.F.Hunt. Thermodynamic Correction of F508DEL-Cftr By Ligand Binding to A Remote Site in the Mutated Domain To Be Published.
Page generated: Mon Dec 14 21:11:55 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy