Atomistry » Magnesium » PDB 5t2v-5tfb » 5tfb
Atomistry »
  Magnesium »
    PDB 5t2v-5tfb »
      5tfb »

Magnesium in PDB 5tfb: Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp

Enzymatic activity of Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp

All present enzymatic activity of Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp:
3.6.3.49;

Protein crystallography data

The structure of Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp, PDB code: 5tfb was solved by C.Wang, A.A.Aleksandrov, Z.Yang, F.Forouhar, E.Proctor, P.Kota, J.An, A.Kaplan, N.Khazanov, G.Boel, B.R.Stockwell, H.Senderowitz, N.V.Dokholyan, J.R.Riordan, C.G.Brouillette, J.F.Hunt, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.29 / 1.87
Space group P 43
Cell size a, b, c (Å), α, β, γ (°) 40.293, 40.293, 141.636, 90.00, 90.00, 90.00
R / Rfree (%) 15 / 19.9

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp (pdb code 5tfb). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp, PDB code: 5tfb:

Magnesium binding site 1 out of 1 in 5tfb

Go back to Magnesium Binding Sites List in 5tfb
Magnesium binding site 1 out of 1 in the Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg701

b:10.6
occ:1.00
 NE2 A:GLN493 1.9 47.1 1.0
O1C A:MGP702 1.9 14.9 1.0
OG1 A:THR465 2.0 10.2 1.0
O2B A:MGP702 2.1 10.8 1.0
O A:HOH806 2.2 13.1 1.0
O A:HOH825 2.2 9.7 1.0
OE1 A:GLN493 2.2 28.6 1.0
CD A:GLN493 2.4 5.9 1.0
CB A:THR465 3.2 11.2 1.0
PC A:MGP702 3.2 14.4 1.0
PB A:MGP702 3.3 10.9 1.0
O3B A:MGP702 3.6 12.8 1.0
OD2 A:ASP572 3.9 16.4 1.0
O2C A:MGP702 4.0 13.5 1.0
CG A:GLN493 4.0 27.1 1.0
N A:THR465 4.0 9.3 1.0
O2A A:MGP702 4.0 15.0 1.0
O A:HOH882 4.1 16.1 1.0
OD1 A:ASP572 4.1 13.5 1.0
CA A:THR465 4.1 10.7 1.0
CG2 A:THR465 4.2 13.1 1.0
O3A A:MGP702 4.4 12.4 1.0
CG A:ASP572 4.4 15.8 1.0
O3C A:MGP702 4.4 12.3 1.0
O1B A:MGP702 4.4 11.5 1.0
O A:HOH975 4.5 34.6 1.0
PA A:MGP702 4.7 13.5 1.0
O A:HOH827 4.7 15.7 1.0
O A:HOH990 4.7 36.5 1.0
CB A:GLN493 4.8 13.9 1.0

Reference:

C.Wang, A.A.Aleksandrov, Z.Yang, F.Forouhar, E.Proctor, P.Kota, J.An, A.Kaplan, N.Khazanov, G.Boel, B.R.Stockwell, H.Senderowitz, N.V.Dokholyan, J.R.Riordan, C.G.Brouillette, J.F.Hunt. Thermodynamic Correction of F508DEL-Cftr By Ligand Binding to A Remote Site in the Mutated Domain To Be Published.
Page generated: Mon Sep 30 04:50:17 2024

Last articles

Zn in 9J0N
Zn in 9J0O
Zn in 9J0P
Zn in 9FJX
Zn in 9EKB
Zn in 9C0F
Zn in 9CAH
Zn in 9CH0
Zn in 9CH3
Zn in 9CH1
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy