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Magnesium in PDB 5tfb: Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp

Enzymatic activity of Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp

All present enzymatic activity of Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp:
3.6.3.49;

Protein crystallography data

The structure of Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp, PDB code: 5tfb was solved by C.Wang, A.A.Aleksandrov, Z.Yang, F.Forouhar, E.Proctor, P.Kota, J.An, A.Kaplan, N.Khazanov, G.Boel, B.R.Stockwell, H.Senderowitz, N.V.Dokholyan, J.R.Riordan, C.G.Brouillette, J.F.Hunt, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.29 / 1.87
Space group P 43
Cell size a, b, c (Å), α, β, γ (°) 40.293, 40.293, 141.636, 90.00, 90.00, 90.00
R / Rfree (%) 15 / 19.9

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp (pdb code 5tfb). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp, PDB code: 5tfb:

Magnesium binding site 1 out of 1 in 5tfb

Go back to Magnesium Binding Sites List in 5tfb
Magnesium binding site 1 out of 1 in the Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 7-Methyl-Gtp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg701

b:10.6
occ:1.00
 NE2 A:GLN493 1.9 47.1 1.0
O1C A:MGP702 1.9 14.9 1.0
OG1 A:THR465 2.0 10.2 1.0
O2B A:MGP702 2.1 10.8 1.0
O A:HOH806 2.2 13.1 1.0
O A:HOH825 2.2 9.7 1.0
OE1 A:GLN493 2.2 28.6 1.0
CD A:GLN493 2.4 5.9 1.0
CB A:THR465 3.2 11.2 1.0
PC A:MGP702 3.2 14.4 1.0
PB A:MGP702 3.3 10.9 1.0
O3B A:MGP702 3.6 12.8 1.0
OD2 A:ASP572 3.9 16.4 1.0
O2C A:MGP702 4.0 13.5 1.0
CG A:GLN493 4.0 27.1 1.0
N A:THR465 4.0 9.3 1.0
O2A A:MGP702 4.0 15.0 1.0
O A:HOH882 4.1 16.1 1.0
OD1 A:ASP572 4.1 13.5 1.0
CA A:THR465 4.1 10.7 1.0
CG2 A:THR465 4.2 13.1 1.0
O3A A:MGP702 4.4 12.4 1.0
CG A:ASP572 4.4 15.8 1.0
O3C A:MGP702 4.4 12.3 1.0
O1B A:MGP702 4.4 11.5 1.0
O A:HOH975 4.5 34.6 1.0
PA A:MGP702 4.7 13.5 1.0
O A:HOH827 4.7 15.7 1.0
O A:HOH990 4.7 36.5 1.0
CB A:GLN493 4.8 13.9 1.0

Reference:

C.Wang, A.A.Aleksandrov, Z.Yang, F.Forouhar, E.Proctor, P.Kota, J.An, A.Kaplan, N.Khazanov, G.Boel, B.R.Stockwell, H.Senderowitz, N.V.Dokholyan, J.R.Riordan, C.G.Brouillette, J.F.Hunt. Thermodynamic Correction of F508DEL-Cftr By Ligand Binding to A Remote Site in the Mutated Domain To Be Published.
Page generated: Mon Sep 30 04:50:17 2024

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