Magnesium in PDB 5tfg: Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 5-Methyl-Utp

Enzymatic activity of Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 5-Methyl-Utp

All present enzymatic activity of Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 5-Methyl-Utp:
3.6.3.49;

Protein crystallography data

The structure of Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 5-Methyl-Utp, PDB code: 5tfg was solved by C.Wang, A.A.Aleksandrov, Z.Yang, F.Forouhar, E.Proctor, P.Kota, J.An, A.Kaplan, N.Khazanov, G.Boel, B.R.Stockwell, H.Senderowitz, N.V.Dokholyan, J.R.Riordan, C.G.Brouillette, J.F.Hunt, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.15 / 1.91
Space group P 43
Cell size a, b, c (Å), α, β, γ (°) 40.147, 40.147, 141.787, 90.00, 90.00, 90.00
R / Rfree (%) 15.6 / 18.4

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 5-Methyl-Utp (pdb code 5tfg). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 5-Methyl-Utp, PDB code: 5tfg:

Magnesium binding site 1 out of 1 in 5tfg

Go back to Magnesium Binding Sites List in 5tfg
Magnesium binding site 1 out of 1 in the Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 5-Methyl-Utp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 5-Methyl-Utp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg701

b:14.3
occ:1.00
O28 A:M5T702 2.0 19.7 1.0
OG1 A:THR465 2.0 14.5 1.0
O A:HOH818 2.1 12.6 1.0
OE1 A:GLN493 2.1 15.7 1.0
O22 A:M5T702 2.2 13.4 1.0
O A:HOH812 2.2 13.4 1.0
CD A:GLN493 3.1 20.5 1.0
CB A:THR465 3.1 17.0 1.0
P25 A:M5T702 3.3 16.3 1.0
P21 A:M5T702 3.3 15.5 1.0
NE2 A:GLN493 3.4 19.5 1.0
O24 A:M5T702 3.6 17.8 1.0
OD2 A:ASP572 3.9 17.8 1.0
N A:THR465 4.0 14.1 1.0
O19 A:M5T702 4.0 18.6 1.0
O27 A:M5T702 4.0 16.4 1.0
OD1 A:ASP572 4.1 14.1 1.0
O A:HOH881 4.1 16.0 1.0
CA A:THR465 4.1 14.8 1.0
CG2 A:THR465 4.2 14.4 1.0
O20 A:M5T702 4.4 16.0 1.0
CG A:ASP572 4.4 16.2 1.0
O26 A:M5T702 4.4 18.4 1.0
O23 A:M5T702 4.4 16.0 1.0
CG A:GLN493 4.4 18.9 1.0
P17 A:M5T702 4.7 17.8 1.0
O A:HOH837 4.9 17.3 1.0
CB A:GLN493 5.0 18.3 1.0

Reference:

C.Wang, A.A.Aleksandrov, Z.Yang, F.Forouhar, E.Proctor, P.Kota, J.An, A.Kaplan, N.Khazanov, G.Boel, B.R.Stockwell, H.Senderowitz, N.V.Dokholyan, J.R.Riordan, C.G.Brouillette, J.F.Hunt. Thermodynamic Correction of F508DEL-Cftr By Ligand Binding to A Remote Site in the Mutated Domain To Be Published.
Page generated: Mon Dec 14 21:11:57 2020

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