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Atomistry » Magnesium » PDB 5u51-5uhb » 5u7d | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 5u51-5uhb » 5u7d » |
Magnesium in PDB 5u7d: PDE2 Catalytic Domain Complexed with InhibitorsEnzymatic activity of PDE2 Catalytic Domain Complexed with Inhibitors
All present enzymatic activity of PDE2 Catalytic Domain Complexed with Inhibitors:
3.1.4.17; Protein crystallography data
The structure of PDE2 Catalytic Domain Complexed with Inhibitors, PDB code: 5u7d
was solved by
J.Pandit,
K.Parris,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5u7d:
The structure of PDE2 Catalytic Domain Complexed with Inhibitors also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the PDE2 Catalytic Domain Complexed with Inhibitors
(pdb code 5u7d). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the PDE2 Catalytic Domain Complexed with Inhibitors, PDB code: 5u7d: Jump to Magnesium binding site number: 1; 2; 3; Magnesium binding site 1 out of 3 in 5u7dGo back to Magnesium Binding Sites List in 5u7d
Magnesium binding site 1 out
of 3 in the PDE2 Catalytic Domain Complexed with Inhibitors
Mono view Stereo pair view
Magnesium binding site 2 out of 3 in 5u7dGo back to Magnesium Binding Sites List in 5u7d
Magnesium binding site 2 out
of 3 in the PDE2 Catalytic Domain Complexed with Inhibitors
Mono view Stereo pair view
Magnesium binding site 3 out of 3 in 5u7dGo back to Magnesium Binding Sites List in 5u7d
Magnesium binding site 3 out
of 3 in the PDE2 Catalytic Domain Complexed with Inhibitors
Mono view Stereo pair view
Reference:
C.J.Helal,
E.P.Arnold,
T.L.Boyden,
C.Chang,
T.A.Chappie,
K.F.Fennell,
M.D.Forman,
M.Hajos,
J.F.Harms,
W.E.Hoffman,
J.M.Humphrey,
Z.Kang,
R.J.Kleiman,
B.L.Kormos,
C.W.Lee,
J.Lu,
N.Maklad,
L.Mcdowell,
S.Mente,
R.E.O'connor,
J.Pandit,
M.Piotrowski,
A.W.Schmidt,
C.J.Schmidt,
H.Ueno,
P.R.Verhoest,
E.X.Yang.
Application of Structure-Based Design and Parallel Chemistry to Identify A Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor. J. Med. Chem. V. 60 5673 2017.
Page generated: Mon Sep 30 05:13:06 2024
ISSN: ISSN 1520-4804 PubMed: 28574706 DOI: 10.1021/ACS.JMEDCHEM.7B00397 |
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