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Magnesium in PDB 5ukm: Bovine GRK2 in Complex with Human Gbetagamma Subunits and CCG258208 (14AS)

Enzymatic activity of Bovine GRK2 in Complex with Human Gbetagamma Subunits and CCG258208 (14AS)

All present enzymatic activity of Bovine GRK2 in Complex with Human Gbetagamma Subunits and CCG258208 (14AS):
2.7.11.15;

Protein crystallography data

The structure of Bovine GRK2 in Complex with Human Gbetagamma Subunits and CCG258208 (14AS), PDB code: 5ukm was solved by O.Cruz-Rodriguez, J.J.G.Tesmer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 3.03
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 189.012, 74.150, 123.175, 90.00, 115.46, 90.00
R / Rfree (%) 19.7 / 25.2

Other elements in 5ukm:

The structure of Bovine GRK2 in Complex with Human Gbetagamma Subunits and CCG258208 (14AS) also contains other interesting chemical elements:

Fluorine (F) 1 atom

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Bovine GRK2 in Complex with Human Gbetagamma Subunits and CCG258208 (14AS) (pdb code 5ukm). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Bovine GRK2 in Complex with Human Gbetagamma Subunits and CCG258208 (14AS), PDB code: 5ukm:

Magnesium binding site 1 out of 1 in 5ukm

Go back to Magnesium Binding Sites List in 5ukm
Magnesium binding site 1 out of 1 in the Bovine GRK2 in Complex with Human Gbetagamma Subunits and CCG258208 (14AS)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Bovine GRK2 in Complex with Human Gbetagamma Subunits and CCG258208 (14AS) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg702

b:88.9
occ:1.00
 O A:HIS348 2.2 0.6 1.0
O A:VAL366 2.2 0.6 1.0
O A:GLN363 2.5 0.8 1.0
O A:GLU360 2.8 0.8 1.0
C A:HIS348 3.1 0.3 1.0
C A:VAL366 3.3 0.0 1.0
CA A:HIS348 3.4 0.6 1.0
N A:VAL366 3.6 0.8 1.0
CA A:VAL366 3.7 0.8 1.0
O A:VAL361 3.7 0.5 1.0
C A:GLN363 3.7 0.5 1.0
CB A:VAL366 3.7 0.5 1.0
CE2 A:TYR368 3.8 0.5 1.0
CD2 A:TYR368 3.9 0.4 1.0
CB A:HIS348 3.9 0.1 1.0
C A:GLU360 4.0 0.3 1.0
C A:VAL361 4.2 0.8 1.0
CA A:VAL361 4.3 0.4 1.0
N A:ALA349 4.3 0.2 1.0
O A:ALA349 4.4 0.6 1.0
N A:ALA367 4.4 0.1 1.0
N A:GLY365 4.5 0.4 1.0
N A:VAL361 4.6 0.2 1.0
CG1 A:VAL366 4.6 0.4 1.0
N A:LYS364 4.6 0.1 1.0
C A:ALA349 4.6 0.5 1.0
CA A:LYS364 4.7 0.2 1.0
N A:GLN363 4.7 0.1 1.0
CA A:GLN363 4.7 0.3 1.0
C A:GLY365 4.8 0.6 1.0
CG2 A:VAL366 4.8 0.2 1.0
N A:HIS348 4.8 0.2 1.0
C A:LYS364 4.8 0.8 1.0
CA A:ALA349 4.9 0.5 1.0
CA A:ALA367 4.9 0.9 1.0
CG A:HIS348 5.0 0.7 1.0
O A:PRO347 5.0 0.6 1.0
CB A:GLN363 5.0 0.5 1.0

Reference:

H.V.Waldschmidt, K.T.Homan, M.C.Cato, O.Cruz-Rodriguez, A.Cannavo, M.W.Wilson, J.Song, J.Y.Cheung, W.J.Koch, J.J.Tesmer, S.D.Larsen. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J. Med. Chem. V. 60 3052 2017.
ISSN: ISSN 1520-4804
PubMed: 28323425
DOI: 10.1021/ACS.JMEDCHEM.7B00112
Page generated: Mon Sep 30 05:22:25 2024

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