Magnesium in PDB 5wdx: Structure of NS3 From Hcv Strain Jfh-1 That Is An Unusually Robust Helicase That Is Primed to Bind and Unwind Viral Rna

The structure of Structure of NS3 From Hcv Strain Jfh-1 That Is An Unusually Robust Helicase That Is Primed to Bind and Unwind Viral Rna, PDB code: 5wdx was solved by T.Zhou, A.M.Pyle, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	58.33 / 2.23
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	72.312, 89.415, 98.714, 90.00, 90.00, 90.00
R / Rfree (%)	21.2 / 23.8

The structure of Structure of NS3 From Hcv Strain Jfh-1 That Is An Unusually Robust Helicase That Is Primed to Bind and Unwind Viral Rna also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Magnesium atom in the Structure of NS3 From Hcv Strain Jfh-1 That Is An Unusually Robust Helicase That Is Primed to Bind and Unwind Viral Rna (pdb code 5wdx). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Structure of NS3 From Hcv Strain Jfh-1 That Is An Unusually Robust Helicase That Is Primed to Bind and Unwind Viral Rna, PDB code: 5wdx:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Structure of NS3 From Hcv Strain Jfh-1 That Is An Unusually Robust Helicase That Is Primed to Bind and Unwind Viral Rna


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structure of NS3 From Hcv Strain Jfh-1 That Is An Unusually Robust Helicase That Is Primed to Bind and Unwind Viral Rna within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg702 b:33.4 occ:1.00 H A:SER211 2.5 48.3 1.0 H A:GLY209 2.5 67.9 1.0 HA2 A:GLY209 2.7 62.6 1.0 HB2 A:SER211 2.8 64.5 1.0 N A:GLY209 3.1 56.6 1.0 CA A:GLY209 3.1 52.2 1.0 O A:HOH824 3.1 40.5 1.0 HA2 A:GLY207 3.1 72.5 1.0 N A:SER211 3.3 40.2 1.0 OG1 A:THR212 3.4 46.2 1.0 C A:GLY209 3.4 46.4 1.0 H A:LYS210 3.4 54.1 1.0 H A:THR212 3.5 53.6 1.0 HG1 A:THR212 3.5 55.5 1.0 N A:LYS210 3.5 45.1 1.0 H A:GLY207 3.5 70.8 1.0 CB A:SER211 3.6 53.8 1.0 C A:GLY207 3.7 61.9 1.0 CA A:GLY207 3.7 60.4 1.0 CA A:SER211 3.9 46.4 1.0 N A:THR212 3.9 44.7 1.0 O A:GLY207 4.0 63.9 1.0 HG23 A:THR212 4.0 50.5 1.0 HG2 A:LYS210 4.0 56.6 1.0 OG A:SER211 4.0 62.1 1.0 N A:GLY207 4.0 59.0 1.0 HA3 A:GLY209 4.0 62.6 1.0 HE1 A:PHE238 4.0 52.7 1.0 O A:GLY209 4.1 44.3 1.0 N A:SER208 4.2 61.1 1.0 C A:SER211 4.2 46.9 1.0 C A:SER208 4.3 56.2 1.0 C A:LYS210 4.3 41.8 1.0 H A:SER208 4.4 73.3 1.0 CB A:THR212 4.4 43.7 1.0 HB3 A:SER211 4.4 64.5 1.0 CA A:LYS210 4.5 42.6 1.0 CG2 A:THR212 4.6 42.1 1.0 CE1 A:PHE238 4.6 43.9 1.0 HA3 A:GLY207 4.6 72.5 1.0 HG21 A:THR212 4.7 50.5 1.0 H A:LYS213 4.7 48.4 1.0 HG3 A:LYS210 4.8 56.6 1.0 CA A:THR212 4.8 41.5 1.0 CG A:LYS210 4.8 47.2 1.0 HG A:SER211 4.8 74.6 1.0 HA A:SER211 4.8 55.7 1.0 CA A:SER208 4.9 57.4 1.0 HG A:SER208 5.0 61.9 1.0

Magnesium binding site 2 out of 2 in the Structure of NS3 From Hcv Strain Jfh-1 That Is An Unusually Robust Helicase That Is Primed to Bind and Unwind Viral Rna


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Structure of NS3 From Hcv Strain Jfh-1 That Is An Unusually Robust Helicase That Is Primed to Bind and Unwind Viral Rna within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg703 b:31.2 occ:1.00 HZ1 A:LYS210 2.5 59.5 1.0 H A:ALA323 2.6 49.5 1.0 HE1 A:HIS293 2.8 47.5 1.0 HG2 A:GLU291 2.9 64.1 1.0 NZ A:LYS210 3.3 49.6 1.0 HE2 A:LYS210 3.3 58.0 1.0 HA A:THR322 3.3 46.0 1.0 N A:ALA323 3.4 41.2 1.0 HB2 A:ALA323 3.4 43.9 1.0 HZ3 A:LYS210 3.4 59.5 1.0 HB3 A:ALA323 3.4 43.9 1.0 HA A:GLU291 3.4 44.7 1.0 OG1 A:THR206 3.5 53.5 1.0 HG1 A:THR206 3.6 64.1 1.0 CE1 A:HIS293 3.6 39.6 1.0 CE A:LYS210 3.7 48.4 1.0 CB A:ALA323 3.8 36.6 1.0 CG A:GLU291 3.9 53.5 1.0 HE3 A:LYS210 3.9 58.0 1.0 HZ2 A:LYS210 4.0 59.5 1.0 H A:GLU291 4.0 40.9 1.0 HG23 A:THR206 4.1 61.6 1.0 CA A:THR322 4.1 38.4 1.0 ND1 A:HIS293 4.2 41.0 1.0 C A:THR322 4.2 38.0 1.0 CA A:ALA323 4.2 39.9 1.0 CA A:GLU291 4.2 37.2 1.0 HG3 A:GLU291 4.3 64.1 1.0 OG1 A:THR322 4.3 37.7 1.0 OD1 A:ASP290 4.5 38.2 1.0 CB A:GLU291 4.5 43.5 1.0 HA A:THR206 4.5 62.4 1.0 N A:GLU291 4.6 34.1 1.0 CB A:THR206 4.6 53.1 1.0 H A:THR324 4.6 52.1 1.0 CG2 A:THR206 4.7 51.3 1.0 HB3 A:GLU291 4.7 52.2 1.0 HB1 A:ALA323 4.7 43.9 1.0 HG21 A:THR206 4.7 61.6 1.0 CD A:GLU291 4.8 59.0 1.0 CB A:THR322 4.8 39.3 1.0 NE2 A:HIS293 4.8 41.4 1.0 HA A:ALA323 4.8 47.9 1.0 HG1 A:THR322 4.9 45.3 1.0 HB A:THR322 5.0 47.2 1.0 HE2 A:HIS293 5.0 49.6 1.0

T.Zhou, X.Ren, R.L.Adams, A.M.Pyle. NS3 From Hepatitis C Virus Strain Jfh-1 Is An Unusually Robust Helicase That Is Primed to Bind and Unwind Viral Rna. J. Virol. V. 92 2018.
ISSN: ESSN 1098-5514
PubMed: 29070684
DOI: 10.1128/JVI.01253-17