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Magnesium in PDB 6cwu: Protein Tyrosine Phosphatase 1B F135Y Mutant

Enzymatic activity of Protein Tyrosine Phosphatase 1B F135Y Mutant

All present enzymatic activity of Protein Tyrosine Phosphatase 1B F135Y Mutant:
3.1.3.48;

Protein crystallography data

The structure of Protein Tyrosine Phosphatase 1B F135Y Mutant, PDB code: 6cwu was solved by M.Hjortness, P.Zwart, B.Sankaran, J.M.Fox, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 77.25 / 2.08
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 89.197, 89.197, 105.734, 90.00, 90.00, 120.00
R / Rfree (%) 25.5 / 29.1

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Protein Tyrosine Phosphatase 1B F135Y Mutant (pdb code 6cwu). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Protein Tyrosine Phosphatase 1B F135Y Mutant, PDB code: 6cwu:

Magnesium binding site 1 out of 1 in 6cwu

Go back to Magnesium Binding Sites List in 6cwu
Magnesium binding site 1 out of 1 in the Protein Tyrosine Phosphatase 1B F135Y Mutant


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Protein Tyrosine Phosphatase 1B F135Y Mutant within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg401

b:43.7
occ:1.00
O A:HOH672 2.0 39.4 1.0
O A:HOH600 2.5 29.8 1.0
O A:HOH624 4.0 57.3 1.0
OE1 A:GLU129 4.2 40.1 1.0
O A:HOH711 4.2 40.1 1.0
OE1 A:GLU130 4.4 43.7 1.0
O A:HOH798 4.5 39.9 1.0
OE2 A:GLU130 4.8 46.4 1.0
CD A:GLU129 5.0 41.6 1.0

Reference:

M.K.Hjortness, L.Riccardi, A.Hongdusit, P.H.Zwart, B.Sankaran, M.De Vivo, J.M.Fox. Evolutionarily Conserved Allosteric Communication in Protein Tyrosine Phosphatases. Biochemistry V. 57 6443 2018.
ISSN: ISSN 1520-4995
PubMed: 30289703
DOI: 10.1021/ACS.BIOCHEM.8B00656
Page generated: Mon Sep 30 22:47:23 2024

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