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Magnesium in PDB 6de3: Crystal Structure of the Double Mutant (R39Q/D52N) of the Full-Length NT5C2 in the Active State
Enzymatic activity of Crystal Structure of the Double Mutant (R39Q/D52N) of the Full-Length NT5C2 in the Active State
All present enzymatic activity of Crystal Structure of the Double Mutant (R39Q/D52N) of the Full-Length NT5C2 in the Active State:
3.1.3.5;
3.1.3.5;
Protein crystallography data
The structure of Crystal Structure of the Double Mutant (R39Q/D52N) of the Full-Length NT5C2 in the Active State, PDB code: 6de3
was solved by
F.Forouhar,
C.L.Dieck,
G.Tzoneva,
Z.Carpenter,
A.Ambesi-Impiombato,
M.Sanchez-Martin,
R.Kirschner-Schwabe,
S.Lew,
J.Seetharaman,
A.A.Ferrando,
L.Tong,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 46.18 / 3.06 |
| Space group | I 2 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 92.362, 129.098, 131.016, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 16.7 / 22.6 |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Crystal Structure of the Double Mutant (R39Q/D52N) of the Full-Length NT5C2 in the Active State
(pdb code 6de3). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of the Double Mutant (R39Q/D52N) of the Full-Length NT5C2 in the Active State, PDB code: 6de3:
In total only one binding site of Magnesium was determined in the Crystal Structure of the Double Mutant (R39Q/D52N) of the Full-Length NT5C2 in the Active State, PDB code: 6de3:
Magnesium binding site 1 out of 1 in 6de3
Go back to
Magnesium Binding Sites List in 6de3
Magnesium binding site 1 out
of 1 in the Crystal Structure of the Double Mutant (R39Q/D52N) of the Full-Length NT5C2 in the Active State
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Crystal Structure of the Double Mutant (R39Q/D52N) of the Full-Length NT5C2 in the Active State within 5.0Å range:
|
Reference:
C.L.Dieck,
G.Tzoneva,
F.Forouhar,
Z.Carpenter,
A.Ambesi-Impiombato,
M.Sanchez-Martin,
R.Kirschner-Schwabe,
S.Lew,
J.Seetharaman,
L.Tong,
A.A.Ferrando.
Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell V. 34 136 2018.
ISSN: ISSN 1878-3686
PubMed: 29990496
DOI: 10.1016/J.CCELL.2018.06.003
Page generated: Mon Sep 30 23:07:45 2024
ISSN: ISSN 1878-3686
PubMed: 29990496
DOI: 10.1016/J.CCELL.2018.06.003
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