Magnesium in PDB 6ech: Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp
Enzymatic activity of Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp
All present enzymatic activity of Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp:
2.7.1.40;
Protein crystallography data
The structure of Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp, PDB code: 6ech
was solved by
A.Padyana,
S.Tong,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
49.52 /
2.19
|
Space group
|
P 21 21 21
|
Cell size a, b, c (Å), α, β, γ (°)
|
86.550,
108.900,
296.840,
90.00,
90.00,
90.00
|
R / Rfree (%)
|
18.1 /
23.8
|
Other elements in 6ech:
The structure of Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp also contains other interesting chemical elements:
Magnesium Binding Sites:
Pages:
>>> Page 1 <<<
Page 2, Binding sites: 11 -
13;
Binding sites:
The binding sites of Magnesium atom in the Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp
(pdb code 6ech). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 13 binding sites of Magnesium where determined in the
Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp, PDB code: 6ech:
Jump to Magnesium binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
9;
10;
Magnesium binding site 1 out
of 13 in 6ech
Go back to
Magnesium Binding Sites List in 6ech
Magnesium binding site 1 out
of 13 in the Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp
Mono view
Stereo pair view
|
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Mg602
b:34.6
occ:1.00
|
OD2
|
A:ASP308
|
2.0
|
37.0
|
1.0
|
O3G
|
A:ATP606
|
2.2
|
32.1
|
1.0
|
O3
|
A:OXL607
|
2.2
|
37.3
|
1.0
|
OE2
|
A:GLU284
|
2.3
|
33.8
|
1.0
|
O4
|
A:OXL607
|
2.4
|
35.7
|
1.0
|
C1
|
A:OXL607
|
3.1
|
35.8
|
1.0
|
CG
|
A:ASP308
|
3.1
|
38.5
|
1.0
|
C2
|
A:OXL607
|
3.2
|
33.0
|
1.0
|
CD
|
A:GLU284
|
3.2
|
34.4
|
1.0
|
PG
|
A:ATP606
|
3.3
|
32.7
|
1.0
|
OE1
|
A:GLU284
|
3.5
|
35.0
|
1.0
|
O2G
|
A:ATP606
|
3.8
|
33.4
|
1.0
|
CB
|
A:ASP308
|
3.8
|
36.9
|
1.0
|
MG
|
A:MG605
|
3.9
|
69.5
|
1.0
|
O1G
|
A:ATP606
|
4.0
|
34.6
|
1.0
|
NZ
|
A:LYS282
|
4.1
|
42.7
|
1.0
|
OD1
|
A:ASP308
|
4.2
|
40.9
|
1.0
|
O1
|
A:OXL607
|
4.2
|
41.1
|
1.0
|
CE2
|
A:PHE256
|
4.3
|
42.7
|
1.0
|
O2
|
A:OXL607
|
4.4
|
32.8
|
1.0
|
N
|
A:ASP308
|
4.5
|
33.1
|
1.0
|
O3B
|
A:ATP606
|
4.5
|
36.2
|
1.0
|
CE
|
A:LYS282
|
4.5
|
41.6
|
1.0
|
O
|
A:HOH740
|
4.5
|
46.0
|
1.0
|
CG
|
A:GLU284
|
4.6
|
37.9
|
1.0
|
CA
|
A:ASP308
|
4.7
|
35.4
|
1.0
|
CB
|
A:ALA305
|
4.8
|
31.8
|
1.0
|
CD2
|
A:PHE256
|
4.9
|
44.8
|
1.0
|
OD1
|
A:ASP190
|
5.0
|
32.7
|
1.0
|
|
Magnesium binding site 2 out
of 13 in 6ech
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Magnesium Binding Sites List in 6ech
Magnesium binding site 2 out
of 13 in the Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp
Mono view
Stereo pair view
|
A full contact list of Magnesium with other atoms in the Mg binding
site number 2 of Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Mg603
b:49.8
occ:1.00
|
O1A
|
A:ATP606
|
2.1
|
34.8
|
1.0
|
O1G
|
A:ATP606
|
2.1
|
34.6
|
1.0
|
O1B
|
A:ATP606
|
2.3
|
31.0
|
1.0
|
PG
|
A:ATP606
|
3.3
|
32.7
|
1.0
|
PB
|
A:ATP606
|
3.4
|
33.8
|
1.0
|
PA
|
A:ATP606
|
3.4
|
32.5
|
1.0
|
O3G
|
A:ATP606
|
3.6
|
32.1
|
1.0
|
O3B
|
A:ATP606
|
3.7
|
36.2
|
1.0
|
O3A
|
A:ATP606
|
3.7
|
30.6
|
1.0
|
OD2
|
A:ASP190
|
3.8
|
37.8
|
1.0
|
C1
|
A:OXL607
|
4.0
|
35.8
|
1.0
|
C2
|
A:OXL607
|
4.1
|
33.0
|
1.0
|
O1
|
A:OXL607
|
4.1
|
41.1
|
1.0
|
CG2
|
A:THR340
|
4.1
|
33.7
|
1.0
|
O
|
A:HOH725
|
4.2
|
37.9
|
1.0
|
OG1
|
A:THR340
|
4.3
|
30.9
|
1.0
|
O2
|
A:OXL607
|
4.3
|
32.8
|
1.0
|
OG
|
A:SER374
|
4.4
|
34.9
|
1.0
|
O4
|
A:OXL607
|
4.4
|
35.7
|
1.0
|
CB
|
A:SER374
|
4.5
|
33.9
|
1.0
|
O3
|
A:OXL607
|
4.5
|
37.3
|
1.0
|
O
|
A:HOH731
|
4.5
|
40.0
|
1.0
|
O2A
|
A:ATP606
|
4.5
|
28.1
|
1.0
|
O5'
|
A:ATP606
|
4.6
|
31.4
|
1.0
|
O2G
|
A:ATP606
|
4.6
|
33.4
|
1.0
|
O
|
A:HOH781
|
4.7
|
35.1
|
1.0
|
NH1
|
A:ARG85
|
4.7
|
38.6
|
1.0
|
O2B
|
A:ATP606
|
4.8
|
38.5
|
1.0
|
C5'
|
A:ATP606
|
4.8
|
31.6
|
1.0
|
CG
|
A:ASP190
|
4.8
|
40.0
|
1.0
|
CB
|
A:THR340
|
4.9
|
30.5
|
1.0
|
|
Magnesium binding site 3 out
of 13 in 6ech
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Magnesium Binding Sites List in 6ech
Magnesium binding site 3 out
of 13 in the Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp
Mono view
Stereo pair view
|
A full contact list of Magnesium with other atoms in the Mg binding
site number 3 of Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Mg604
b:25.0
occ:1.00
|
OD1
|
A:ASP125
|
2.4
|
35.5
|
1.0
|
O
|
A:HOH740
|
2.7
|
46.0
|
1.0
|
O
|
A:THR126
|
2.7
|
31.1
|
1.0
|
O2G
|
A:ATP606
|
2.7
|
33.4
|
1.0
|
OD1
|
A:ASN87
|
2.8
|
34.3
|
1.0
|
OG
|
A:SER89
|
2.8
|
39.2
|
1.0
|
OG
|
A:SER255
|
3.3
|
35.0
|
1.0
|
CG
|
A:ASN87
|
3.6
|
33.1
|
1.0
|
CG
|
A:ASP125
|
3.6
|
35.5
|
1.0
|
ND2
|
A:ASN87
|
3.7
|
30.9
|
1.0
|
CB
|
A:SER89
|
3.8
|
39.3
|
1.0
|
C
|
A:THR126
|
3.8
|
31.0
|
1.0
|
NZ
|
A:LYS282
|
4.0
|
42.7
|
1.0
|
PG
|
A:ATP606
|
4.2
|
32.7
|
1.0
|
O
|
A:ASP125
|
4.3
|
33.2
|
1.0
|
N
|
A:SER89
|
4.4
|
34.2
|
1.0
|
OD2
|
A:ASP125
|
4.4
|
32.2
|
1.0
|
CA
|
A:LYS127
|
4.4
|
36.9
|
1.0
|
CB
|
A:SER255
|
4.4
|
35.3
|
1.0
|
C
|
A:ASP125
|
4.4
|
33.8
|
1.0
|
N
|
A:LYS127
|
4.5
|
34.0
|
1.0
|
N
|
A:THR126
|
4.5
|
34.7
|
1.0
|
CB
|
A:ASP125
|
4.5
|
34.5
|
1.0
|
OE1
|
A:GLU130
|
4.6
|
41.6
|
1.0
|
OE2
|
A:GLU130
|
4.6
|
44.4
|
1.0
|
NH2
|
A:ARG132
|
4.6
|
37.8
|
1.0
|
O
|
A:LYS127
|
4.7
|
37.2
|
1.0
|
CA
|
A:SER89
|
4.7
|
36.1
|
1.0
|
O3B
|
A:ATP606
|
4.7
|
36.2
|
1.0
|
NH1
|
A:ARG85
|
4.7
|
38.6
|
1.0
|
CA
|
A:THR126
|
4.8
|
32.4
|
1.0
|
CB
|
A:ASN87
|
4.9
|
31.5
|
1.0
|
CD
|
A:GLU130
|
4.9
|
42.0
|
1.0
|
C
|
A:LYS127
|
5.0
|
38.6
|
1.0
|
|
Magnesium binding site 4 out
of 13 in 6ech
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Magnesium Binding Sites List in 6ech
Magnesium binding site 4 out
of 13 in the Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp
Mono view
Stereo pair view
|
A full contact list of Magnesium with other atoms in the Mg binding
site number 4 of Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Mg605
b:69.5
occ:1.00
|
O
|
A:HOH934
|
2.5
|
44.6
|
1.0
|
OD2
|
A:ASP308
|
2.6
|
37.0
|
1.0
|
O
|
A:HOH766
|
2.7
|
32.0
|
1.0
|
OD1
|
A:ASP308
|
2.7
|
40.9
|
1.0
|
CG
|
A:ASP308
|
3.0
|
38.5
|
1.0
|
O3G
|
A:ATP606
|
3.4
|
32.1
|
1.0
|
OD1
|
A:ASP190
|
3.4
|
32.7
|
1.0
|
NH2
|
A:ARG132
|
3.5
|
37.8
|
1.0
|
CA
|
A:GLY220
|
3.6
|
43.6
|
1.0
|
MG
|
A:MG602
|
3.9
|
34.6
|
1.0
|
O
|
A:HOH861
|
4.1
|
38.6
|
1.0
|
CZ
|
A:ARG132
|
4.3
|
39.4
|
1.0
|
N
|
A:GLY220
|
4.4
|
46.1
|
1.0
|
O3B
|
A:ATP606
|
4.4
|
36.2
|
1.0
|
OE2
|
A:GLU130
|
4.4
|
44.4
|
1.0
|
CB
|
A:ASP308
|
4.5
|
36.9
|
1.0
|
PG
|
A:ATP606
|
4.6
|
32.7
|
1.0
|
CG
|
A:ASP190
|
4.6
|
40.0
|
1.0
|
C
|
A:GLY220
|
4.6
|
39.9
|
1.0
|
ND2
|
A:ASN222
|
4.7
|
31.2
|
1.0
|
CE2
|
A:PHE256
|
4.8
|
42.7
|
1.0
|
NH1
|
A:ARG132
|
4.8
|
35.4
|
1.0
|
O
|
A:HOH862
|
4.9
|
37.6
|
1.0
|
|
Magnesium binding site 5 out
of 13 in 6ech
Go back to
Magnesium Binding Sites List in 6ech
Magnesium binding site 5 out
of 13 in the Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp
Mono view
Stereo pair view
|
A full contact list of Magnesium with other atoms in the Mg binding
site number 5 of Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Mg602
b:38.6
occ:1.00
|
O1
|
B:OXL607
|
2.0
|
37.0
|
1.0
|
O2
|
B:OXL607
|
2.1
|
33.6
|
1.0
|
OD2
|
B:ASP308
|
2.1
|
33.3
|
1.0
|
O2G
|
B:ATP606
|
2.2
|
25.1
|
1.0
|
OE2
|
B:GLU284
|
2.2
|
38.5
|
1.0
|
C1
|
B:OXL607
|
2.9
|
45.3
|
1.0
|
C2
|
B:OXL607
|
2.9
|
41.0
|
1.0
|
CG
|
B:ASP308
|
3.2
|
33.3
|
1.0
|
CD
|
B:GLU284
|
3.3
|
39.9
|
1.0
|
PG
|
B:ATP606
|
3.3
|
31.5
|
1.0
|
OE1
|
B:GLU284
|
3.6
|
39.1
|
1.0
|
CB
|
B:ASP308
|
3.7
|
32.7
|
1.0
|
O1G
|
B:ATP606
|
3.8
|
31.1
|
1.0
|
O
|
B:HOH753
|
4.0
|
32.5
|
1.0
|
NZ
|
B:LYS282
|
4.1
|
41.8
|
1.0
|
O3G
|
B:ATP606
|
4.1
|
33.2
|
1.0
|
O3
|
B:OXL607
|
4.1
|
44.6
|
1.0
|
O4
|
B:OXL607
|
4.2
|
36.4
|
1.0
|
MG
|
B:MG605
|
4.3
|
44.4
|
1.0
|
OD1
|
B:ASP308
|
4.3
|
31.8
|
1.0
|
N
|
B:ASP308
|
4.4
|
31.0
|
1.0
|
CE2
|
B:PHE256
|
4.4
|
49.1
|
1.0
|
CE
|
B:LYS282
|
4.4
|
38.1
|
1.0
|
O3B
|
B:ATP606
|
4.5
|
33.8
|
1.0
|
CG
|
B:GLU284
|
4.6
|
38.9
|
1.0
|
CA
|
B:ASP308
|
4.7
|
31.5
|
1.0
|
O
|
B:HOH837
|
4.7
|
36.6
|
1.0
|
CB
|
B:ALA305
|
4.8
|
37.2
|
1.0
|
CZ
|
B:PHE256
|
4.8
|
46.8
|
1.0
|
OD1
|
B:ASP190
|
5.0
|
34.0
|
1.0
|
CB
|
B:GLU284
|
5.0
|
39.8
|
1.0
|
|
Magnesium binding site 6 out
of 13 in 6ech
Go back to
Magnesium Binding Sites List in 6ech
Magnesium binding site 6 out
of 13 in the Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp
Mono view
Stereo pair view
|
A full contact list of Magnesium with other atoms in the Mg binding
site number 6 of Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Mg603
b:25.9
occ:1.00
|
O
|
B:HOH837
|
2.5
|
36.6
|
1.0
|
OD1
|
B:ASN87
|
2.5
|
40.2
|
1.0
|
OD1
|
B:ASP125
|
2.5
|
36.4
|
1.0
|
O1G
|
B:ATP606
|
2.6
|
31.1
|
1.0
|
O
|
B:THR126
|
2.8
|
37.8
|
1.0
|
OG
|
B:SER89
|
3.0
|
39.0
|
1.0
|
CG
|
B:ASN87
|
3.4
|
37.9
|
1.0
|
OG
|
B:SER255
|
3.4
|
34.4
|
1.0
|
CG
|
B:ASP125
|
3.7
|
37.4
|
1.0
|
CB
|
B:SER89
|
3.7
|
39.0
|
1.0
|
ND2
|
B:ASN87
|
3.8
|
38.5
|
1.0
|
C
|
B:THR126
|
3.8
|
39.9
|
1.0
|
NZ
|
B:LYS282
|
4.1
|
41.8
|
1.0
|
PG
|
B:ATP606
|
4.1
|
31.5
|
1.0
|
O
|
B:ASP125
|
4.2
|
40.0
|
1.0
|
NH2
|
B:ARG132
|
4.3
|
42.0
|
1.0
|
N
|
B:SER89
|
4.4
|
41.2
|
1.0
|
OD2
|
B:ASP125
|
4.4
|
40.4
|
1.0
|
CB
|
B:SER255
|
4.4
|
36.9
|
1.0
|
CA
|
B:LYS127
|
4.5
|
42.0
|
1.0
|
C
|
B:ASP125
|
4.5
|
36.0
|
1.0
|
N
|
B:LYS127
|
4.5
|
39.8
|
1.0
|
NH1
|
B:ARG85
|
4.5
|
31.9
|
1.0
|
CB
|
B:ASP125
|
4.6
|
38.1
|
1.0
|
CA
|
B:SER89
|
4.6
|
38.1
|
1.0
|
O3B
|
B:ATP606
|
4.6
|
33.8
|
1.0
|
N
|
B:THR126
|
4.7
|
39.4
|
1.0
|
OE2
|
B:GLU130
|
4.7
|
48.8
|
1.0
|
OE1
|
B:GLU130
|
4.7
|
41.2
|
1.0
|
O
|
B:LYS127
|
4.7
|
36.6
|
1.0
|
CB
|
B:ASN87
|
4.7
|
36.7
|
1.0
|
O2G
|
B:ATP606
|
4.8
|
25.1
|
1.0
|
CA
|
B:THR126
|
4.9
|
38.1
|
1.0
|
N
|
B:PHE88
|
4.9
|
40.5
|
1.0
|
|
Magnesium binding site 7 out
of 13 in 6ech
Go back to
Magnesium Binding Sites List in 6ech
Magnesium binding site 7 out
of 13 in the Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp
Mono view
Stereo pair view
|
A full contact list of Magnesium with other atoms in the Mg binding
site number 7 of Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Mg604
b:35.8
occ:1.00
|
O3G
|
B:ATP606
|
2.0
|
33.2
|
1.0
|
O2A
|
B:ATP606
|
2.0
|
37.0
|
1.0
|
O1B
|
B:ATP606
|
2.2
|
28.2
|
1.0
|
O
|
B:HOH714
|
2.3
|
25.4
|
1.0
|
PB
|
B:ATP606
|
3.2
|
37.4
|
1.0
|
PG
|
B:ATP606
|
3.2
|
31.5
|
1.0
|
PA
|
B:ATP606
|
3.3
|
36.0
|
1.0
|
O3B
|
B:ATP606
|
3.5
|
33.8
|
1.0
|
O3A
|
B:ATP606
|
3.5
|
33.7
|
1.0
|
O2G
|
B:ATP606
|
3.6
|
25.1
|
1.0
|
OD2
|
B:ASP190
|
3.8
|
35.5
|
1.0
|
C1
|
B:OXL607
|
4.1
|
45.3
|
1.0
|
OG
|
B:SER374
|
4.1
|
32.4
|
1.0
|
C2
|
B:OXL607
|
4.1
|
41.0
|
1.0
|
O
|
B:HOH746
|
4.1
|
38.4
|
1.0
|
O3
|
B:OXL607
|
4.2
|
44.6
|
1.0
|
O
|
B:HOH721
|
4.2
|
38.9
|
1.0
|
CG2
|
B:THR340
|
4.3
|
35.1
|
1.0
|
O4
|
B:OXL607
|
4.4
|
36.4
|
1.0
|
O1A
|
B:ATP606
|
4.4
|
33.6
|
1.0
|
O2
|
B:OXL607
|
4.4
|
33.6
|
1.0
|
CB
|
B:SER374
|
4.5
|
35.1
|
1.0
|
OG1
|
B:THR340
|
4.5
|
35.7
|
1.0
|
O5'
|
B:ATP606
|
4.5
|
35.0
|
1.0
|
O1
|
B:OXL607
|
4.5
|
37.0
|
1.0
|
C5'
|
B:ATP606
|
4.5
|
36.6
|
1.0
|
O
|
B:HOH753
|
4.6
|
32.5
|
1.0
|
O
|
B:HOH828
|
4.6
|
32.2
|
1.0
|
O1G
|
B:ATP606
|
4.6
|
31.1
|
1.0
|
O2B
|
B:ATP606
|
4.6
|
35.0
|
1.0
|
NH1
|
B:ARG85
|
4.8
|
31.9
|
1.0
|
CG
|
B:ASP190
|
4.9
|
35.4
|
1.0
|
|
Magnesium binding site 8 out
of 13 in 6ech
Go back to
Magnesium Binding Sites List in 6ech
Magnesium binding site 8 out
of 13 in the Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp
Mono view
Stereo pair view
|
A full contact list of Magnesium with other atoms in the Mg binding
site number 8 of Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Mg605
b:44.4
occ:1.00
|
OD1
|
B:ASP308
|
2.4
|
31.8
|
1.0
|
O
|
B:HOH753
|
2.4
|
32.5
|
1.0
|
O
|
B:HOH726
|
2.6
|
35.4
|
1.0
|
OD2
|
B:ASP308
|
2.6
|
33.3
|
1.0
|
CG
|
B:ASP308
|
2.8
|
33.3
|
1.0
|
CA
|
B:GLY220
|
3.6
|
32.6
|
1.0
|
OD1
|
B:ASP190
|
3.7
|
34.0
|
1.0
|
NH2
|
B:ARG132
|
4.0
|
42.0
|
1.0
|
O2G
|
B:ATP606
|
4.0
|
25.1
|
1.0
|
ND2
|
B:ASN222
|
4.3
|
32.2
|
1.0
|
CZ
|
B:PHE256
|
4.3
|
46.8
|
1.0
|
MG
|
B:MG602
|
4.3
|
38.6
|
1.0
|
O
|
B:HOH831
|
4.3
|
40.1
|
1.0
|
CE2
|
B:PHE256
|
4.3
|
49.1
|
1.0
|
CB
|
B:ASP308
|
4.4
|
32.7
|
1.0
|
OE2
|
B:GLU130
|
4.4
|
48.8
|
1.0
|
C
|
B:GLY220
|
4.4
|
32.8
|
1.0
|
O
|
B:HOH865
|
4.4
|
33.8
|
1.0
|
N
|
B:GLY220
|
4.5
|
35.4
|
1.0
|
OD1
|
B:ASN222
|
4.5
|
45.4
|
1.0
|
CZ
|
B:ARG132
|
4.5
|
39.6
|
1.0
|
N
|
B:VAL221
|
4.8
|
32.5
|
1.0
|
CG
|
B:ASN222
|
4.8
|
36.6
|
1.0
|
NE
|
B:ARG132
|
4.9
|
38.9
|
1.0
|
CG
|
B:ASP190
|
4.9
|
35.4
|
1.0
|
O3B
|
B:ATP606
|
5.0
|
33.8
|
1.0
|
|
Magnesium binding site 9 out
of 13 in 6ech
Go back to
Magnesium Binding Sites List in 6ech
Magnesium binding site 9 out
of 13 in the Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp
Mono view
Stereo pair view
|
A full contact list of Magnesium with other atoms in the Mg binding
site number 9 of Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Mg602
b:47.7
occ:1.00
|
OD2
|
C:ASP308
|
2.0
|
36.1
|
1.0
|
OE2
|
C:GLU284
|
2.1
|
32.6
|
1.0
|
O1
|
C:OXL604
|
2.3
|
33.5
|
1.0
|
O2
|
C:OXL604
|
2.3
|
44.2
|
1.0
|
CD
|
C:GLU284
|
3.1
|
32.4
|
1.0
|
C1
|
C:OXL604
|
3.1
|
43.7
|
1.0
|
C2
|
C:OXL604
|
3.2
|
43.0
|
1.0
|
CG
|
C:ASP308
|
3.2
|
37.8
|
1.0
|
OE1
|
C:GLU284
|
3.4
|
34.0
|
1.0
|
O
|
C:HOH851
|
3.6
|
43.4
|
1.0
|
CB
|
C:ASP308
|
3.8
|
39.0
|
1.0
|
O
|
C:HOH800
|
3.8
|
48.4
|
1.0
|
CZ
|
C:PHE256
|
4.0
|
57.3
|
1.0
|
NZ
|
C:LYS282
|
4.1
|
39.3
|
1.0
|
OD1
|
C:ASP308
|
4.2
|
40.2
|
1.0
|
CE2
|
C:PHE256
|
4.3
|
55.5
|
1.0
|
O
|
C:HOH806
|
4.4
|
49.7
|
1.0
|
O3
|
C:OXL604
|
4.4
|
50.2
|
1.0
|
O4
|
C:OXL604
|
4.4
|
37.7
|
1.0
|
CG
|
C:GLU284
|
4.5
|
38.6
|
1.0
|
N
|
C:ASP308
|
4.6
|
32.7
|
1.0
|
CE
|
C:LYS282
|
4.6
|
37.5
|
1.0
|
CE1
|
C:PHE256
|
4.7
|
51.0
|
1.0
|
CA
|
C:ASP308
|
4.8
|
36.9
|
1.0
|
O
|
C:HOH764
|
4.9
|
44.2
|
1.0
|
CB
|
C:ALA305
|
5.0
|
34.4
|
1.0
|
O
|
C:HOH971
|
5.0
|
51.4
|
1.0
|
|
Magnesium binding site 10 out
of 13 in 6ech
Go back to
Magnesium Binding Sites List in 6ech
Magnesium binding site 10 out
of 13 in the Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp
Mono view
Stereo pair view
|
A full contact list of Magnesium with other atoms in the Mg binding
site number 10 of Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Mg603
b:26.8
occ:1.00
|
O
|
C:HOH806
|
2.6
|
49.7
|
1.0
|
O
|
C:THR126
|
2.6
|
36.1
|
1.0
|
OD1
|
C:ASN87
|
2.6
|
33.4
|
1.0
|
O
|
C:HOH851
|
2.7
|
43.4
|
1.0
|
OD1
|
C:ASP125
|
2.7
|
41.7
|
1.0
|
OG
|
C:SER89
|
2.8
|
42.0
|
1.0
|
C
|
C:THR126
|
3.6
|
38.7
|
1.0
|
OG
|
C:SER255
|
3.6
|
29.0
|
1.0
|
CG
|
C:ASP125
|
3.7
|
39.6
|
1.0
|
CG
|
C:ASN87
|
3.7
|
29.7
|
1.0
|
CB
|
C:SER89
|
3.7
|
42.4
|
1.0
|
O
|
C:ASP125
|
3.9
|
36.6
|
1.0
|
NZ
|
C:LYS282
|
4.0
|
39.3
|
1.0
|
N
|
C:SER89
|
4.1
|
39.8
|
1.0
|
CA
|
C:LYS127
|
4.1
|
41.9
|
1.0
|
O
|
C:HOH865
|
4.2
|
48.5
|
1.0
|
N
|
C:LYS127
|
4.2
|
40.2
|
1.0
|
C
|
C:ASP125
|
4.2
|
35.1
|
1.0
|
ND2
|
C:ASN87
|
4.3
|
30.6
|
1.0
|
OD2
|
C:ASP125
|
4.4
|
42.2
|
1.0
|
NH2
|
C:ARG85
|
4.4
|
29.6
|
1.0
|
CA
|
C:SER89
|
4.5
|
39.2
|
1.0
|
O
|
C:LYS127
|
4.5
|
38.5
|
1.0
|
CB
|
C:ASP125
|
4.5
|
34.9
|
1.0
|
N
|
C:THR126
|
4.5
|
35.3
|
1.0
|
C
|
C:LYS127
|
4.7
|
37.4
|
1.0
|
N
|
C:PHE88
|
4.7
|
34.1
|
1.0
|
CA
|
C:THR126
|
4.7
|
38.0
|
1.0
|
OE2
|
C:GLU130
|
4.7
|
53.5
|
1.0
|
CB
|
C:SER255
|
4.8
|
32.9
|
1.0
|
CB
|
C:ASN87
|
4.9
|
28.2
|
1.0
|
CA
|
C:ASN87
|
4.9
|
29.1
|
1.0
|
C
|
C:PHE88
|
4.9
|
35.7
|
1.0
|
CA
|
C:ASP125
|
5.0
|
32.8
|
1.0
|
|
Reference:
B.M.Gassaway,
R.L.Cardone,
A.K.Padyana,
M.C.Petersen,
E.T.Judd,
S.Hayes,
S.Tong,
K.W.Barber,
M.Apostolidi,
A.Abulizi,
J.B.Sheetz,
G.Kshitiz,
H.R.Aerni,
S.Gross,
C.Kung,
V.T.Samuel,
G.I.Shulman,
R.G.Kibbey,
J.Rinehart.
Distinct Hepatic Pka and Cdk Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production. Cell Rep 2019.
ISSN: ESSN 2211-1247
Page generated: Mon Sep 30 23:52:22 2024
|