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Magnesium in PDB 6fcb: Human Methionine Adenosyltransferase II Mutant (P115G)

Enzymatic activity of Human Methionine Adenosyltransferase II Mutant (P115G)

All present enzymatic activity of Human Methionine Adenosyltransferase II Mutant (P115G):
2.5.1.6;

Protein crystallography data

The structure of Human Methionine Adenosyltransferase II Mutant (P115G), PDB code: 6fcb was solved by J.Panmanee, S.V.Antonyuk, S.S.Hasnain, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 54.36 / 2.70
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 66.330, 94.870, 117.370, 90.00, 90.00, 90.00
R / Rfree (%) 19.2 / 23.4

Other elements in 6fcb:

The structure of Human Methionine Adenosyltransferase II Mutant (P115G) also contains other interesting chemical elements:

Potassium (K) 1 atom

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Human Methionine Adenosyltransferase II Mutant (P115G) (pdb code 6fcb). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Human Methionine Adenosyltransferase II Mutant (P115G), PDB code: 6fcb:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 6fcb

Go back to Magnesium Binding Sites List in 6fcb
Magnesium binding site 1 out of 2 in the Human Methionine Adenosyltransferase II Mutant (P115G)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Human Methionine Adenosyltransferase II Mutant (P115G) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg402

b:49.3
occ:0.90
OD2 A:ASP31 2.2 47.1 1.0
OD1 A:ASP31 2.3 48.9 1.0
O1B A:PPK401 2.5 43.6 1.0
CG A:ASP31 2.6 43.8 1.0
O2G A:PPK401 2.6 38.7 1.0
K A:K404 3.1 34.9 0.7
O1A A:PPK401 3.1 45.7 1.0
NH2 A:ARG264 3.8 41.0 1.0
O A:ALA259 3.8 36.4 1.0
PB A:PPK401 4.0 50.9 1.0
CB A:ARG264 4.1 35.8 1.0
PG A:PPK401 4.1 45.5 1.0
CB A:ASP31 4.1 40.1 1.0
CZ A:ARG264 4.1 39.9 1.0
NE A:ARG264 4.1 39.9 1.0
NZ A:LYS265 4.2 35.8 1.0
OD2 A:ASP258 4.3 52.9 0.8
N3B A:PPK401 4.5 47.4 1.0
CG A:ARG264 4.5 37.5 1.0
PA A:PPK401 4.6 44.3 1.0
N A:LEU261 4.6 39.2 1.0
O3A A:PPK401 4.7 49.2 1.0
CA A:GLY260 4.8 39.7 1.0
CE1 A:HIS29 4.8 35.7 1.0
O1G A:PPK401 4.8 39.8 1.0
NH1 A:ARG264 4.9 40.6 1.0
CA A:ASP31 4.9 37.8 1.0
O A:ARG264 4.9 36.9 1.0
C A:ALA259 4.9 39.6 1.0
CD A:ARG264 5.0 37.9 1.0
O2B A:PPK401 5.0 51.4 1.0

Magnesium binding site 2 out of 2 in 6fcb

Go back to Magnesium Binding Sites List in 6fcb
Magnesium binding site 2 out of 2 in the Human Methionine Adenosyltransferase II Mutant (P115G)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Human Methionine Adenosyltransferase II Mutant (P115G) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg403

b:27.7
occ:0.75
O4A A:PPK401 2.2 44.3 1.0
O3G A:PPK401 2.4 49.2 1.0
N3B A:PPK401 3.2 47.4 1.0
PG A:PPK401 3.4 45.5 1.0
PA A:PPK401 3.4 44.3 1.0
O3A A:PPK401 3.4 49.2 1.0
PB A:PPK401 4.0 50.9 1.0
OE2 A:GLU23 4.1 44.4 1.0
O1G A:PPK401 4.3 39.8 1.0
O2A A:PPK401 4.4 36.8 1.0
O1A A:PPK401 4.4 45.7 1.0
NZ A:LYS181 4.5 43.5 1.0
NZ A:LYS265 4.5 35.8 1.0
O2G A:PPK401 4.6 38.7 1.0
OE1 A:GLU23 4.8 43.8 1.0
CD A:GLU23 4.9 44.2 1.0
O2B A:PPK401 5.0 51.4 1.0

Reference:

J.Panmanee, J.Bradley-Clarke, J.M.Mato, P.M.O'neill, S.V.Antonyuk, S.S.Hasnain. Control and Regulation of S-Adenosylmethionine Biosynthesis By the Regulatory Beta Subunit and Quinolone-Based Compounds. Febs J. V. 286 2135 2019.
ISSN: ISSN 1742-464X
PubMed: 30776190
DOI: 10.1111/FEBS.14790
Page generated: Tue Oct 1 00:19:33 2024

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