Atomistry » Magnesium » PDB 6fch-6fjk » 6fd6
Atomistry »
  Magnesium »
    PDB 6fch-6fjk »
      6fd6 »

Magnesium in PDB 6fd6: Crystal Structure of Human Aprt-TYR105PHE Variant in Complex with Adenine, Prpp and MG2+, 30 Days Post Crystallization (with Amp and Ppi Products Fully Generated)

Enzymatic activity of Crystal Structure of Human Aprt-TYR105PHE Variant in Complex with Adenine, Prpp and MG2+, 30 Days Post Crystallization (with Amp and Ppi Products Fully Generated)

All present enzymatic activity of Crystal Structure of Human Aprt-TYR105PHE Variant in Complex with Adenine, Prpp and MG2+, 30 Days Post Crystallization (with Amp and Ppi Products Fully Generated):
2.4.2.7;

Protein crystallography data

The structure of Crystal Structure of Human Aprt-TYR105PHE Variant in Complex with Adenine, Prpp and MG2+, 30 Days Post Crystallization (with Amp and Ppi Products Fully Generated), PDB code: 6fd6 was solved by P.Nioche, J.Huyet, M.Ozeir, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 44.62 / 1.80
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 47.170, 47.790, 47.920, 76.93, 61.50, 69.41
R / Rfree (%) 15.1 / 18.3

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of Human Aprt-TYR105PHE Variant in Complex with Adenine, Prpp and MG2+, 30 Days Post Crystallization (with Amp and Ppi Products Fully Generated) (pdb code 6fd6). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Human Aprt-TYR105PHE Variant in Complex with Adenine, Prpp and MG2+, 30 Days Post Crystallization (with Amp and Ppi Products Fully Generated), PDB code: 6fd6:

Magnesium binding site 1 out of 1 in 6fd6

Go back to Magnesium Binding Sites List in 6fd6
Magnesium binding site 1 out of 1 in the Crystal Structure of Human Aprt-TYR105PHE Variant in Complex with Adenine, Prpp and MG2+, 30 Days Post Crystallization (with Amp and Ppi Products Fully Generated)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Human Aprt-TYR105PHE Variant in Complex with Adenine, Prpp and MG2+, 30 Days Post Crystallization (with Amp and Ppi Products Fully Generated) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg202

b:19.1
occ:0.60
 O21 B:PPV203 1.8 29.8 0.6
O22 B:PPV203 2.2 15.5 0.6
O B:HOH304 2.2 26.4 1.0
O3' B:AMP201 2.2 16.5 1.0
O B:HOH333 2.5 39.1 1.0
O2' B:AMP201 2.8 17.4 1.0
P1 B:PPV203 3.1 25.5 0.6
P2 B:PPV203 3.3 21.1 0.6
C3' B:AMP201 3.4 15.7 1.0
OPP B:PPV203 3.5 24.7 0.6
C2' B:AMP201 3.6 15.6 1.0
O32 B:PPV203 3.9 14.7 0.6
NE B:ARG67 4.0 11.4 0.5
O31 B:PPV203 4.0 25.2 0.6
NH2 B:ARG67 4.0 11.2 0.5
OD1 B:ASP127 4.0 10.9 1.0
C1' B:AMP201 4.1 14.2 1.0
OD1 B:ASP128 4.1 12.1 1.0
N B:SER66 4.1 12.4 1.0
OD2 B:ASP127 4.2 12.6 1.0
N B:ARG67 4.2 11.2 1.0
CZ B:ARG67 4.2 12.2 0.5
O B:ASP65 4.2 12.4 1.0
C4' B:AMP201 4.2 14.0 1.0
O11 B:PPV203 4.3 32.7 0.6
CB B:ARG67 4.3 11.3 0.5
CZ B:ARG67 4.3 27.2 0.5
CB B:ARG67 4.3 14.8 0.5
O4' B:AMP201 4.3 14.5 1.0
NH2 B:ARG67 4.4 28.6 0.5
CG B:ARG67 4.5 17.4 0.5
CG B:ASP127 4.5 12.5 1.0
NH1 B:ARG67 4.5 25.2 0.5
O12 B:PPV203 4.6 20.0 0.6
NE B:ARG67 4.6 24.5 0.5
C B:ASP65 4.6 10.9 1.0
O B:HOH344 4.6 29.7 1.0
CG B:ARG67 4.8 11.3 0.5
CA B:ARG67 4.8 10.6 0.5
CA B:ARG67 4.8 12.0 0.5
CD B:ARG67 4.8 12.4 0.5

Reference:

J.Huyet, M.Ozeir, M.C.Burgevin, B.Pinson, F.Chesney, J.M.Remy, A.R.Siddiqi, R.Lupoli, G.Pinon, C.Saint-Marc, J.F.Gibert, R.Morales, I.Ceballos-Picot, R.Barouki, B.Daignan-Fornier, A.Olivier-Bandini, F.Auge, P.Nioche. Structural Insights Into the Forward and Reverse Enzymatic Reactions in Human Adenine Phosphoribosyltransferase. Cell Chem Biol V. 25 666 2018.
ISSN: ESSN 2451-9448
PubMed: 29576532
DOI: 10.1016/J.CHEMBIOL.2018.02.011
Page generated: Tue Oct 1 00:24:26 2024

Last articles

Zn in 9J0N
Zn in 9J0O
Zn in 9J0P
Zn in 9FJX
Zn in 9EKB
Zn in 9C0F
Zn in 9CAH
Zn in 9CH0
Zn in 9CH3
Zn in 9CH1
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy