Magnesium in PDB 6gpo: Structure of Human Heat Shock Protein 90-Alpha N-Terminal Domain (HSP90-Ntd) Variant K112A in Complex with Camp

The structure of Structure of Human Heat Shock Protein 90-Alpha N-Terminal Domain (HSP90-Ntd) Variant K112A in Complex with Camp, PDB code: 6gpo was solved by G.Tassone, C.Pozzi, S.Mangani, M.Botta, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.78 / 1.48
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	54.068, 42.241, 54.555, 90.00, 116.60, 90.00
R / Rfree (%)	16.9 / 21.8

The binding sites of Magnesium atom in the Structure of Human Heat Shock Protein 90-Alpha N-Terminal Domain (HSP90-Ntd) Variant K112A in Complex with Camp (pdb code 6gpo). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Structure of Human Heat Shock Protein 90-Alpha N-Terminal Domain (HSP90-Ntd) Variant K112A in Complex with Camp, PDB code: 6gpo:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Structure of Human Heat Shock Protein 90-Alpha N-Terminal Domain (HSP90-Ntd) Variant K112A in Complex with Camp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structure of Human Heat Shock Protein 90-Alpha N-Terminal Domain (HSP90-Ntd) Variant K112A in Complex with Camp within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg302 b:19.1 occ:1.00 O A:HOH550 2.1 22.3 1.0 O A:HOH463 2.1 23.4 1.0 O A:HOH432 2.1 22.6 1.0 O A:HOH596 2.2 23.0 1.0 OG A:SER53 3.9 15.2 1.0 OD2 A:ASP57 4.0 18.9 1.0 O A:PHE213 4.0 15.6 1.0 O A:HOH460 4.0 25.9 1.0 O A:HOH639 4.1 30.9 1.0 O A:HOH676 4.2 27.7 1.0 O A:HOH543 4.3 29.7 1.0 O A:ILE214 4.4 14.0 1.0 CG A:ASP57 4.9 15.9 1.0

Magnesium binding site 2 out of 2 in the Structure of Human Heat Shock Protein 90-Alpha N-Terminal Domain (HSP90-Ntd) Variant K112A in Complex with Camp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Structure of Human Heat Shock Protein 90-Alpha N-Terminal Domain (HSP90-Ntd) Variant K112A in Complex with Camp within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg303 b:15.8 occ:0.40 O A:HOH608 1.8 20.0 0.5 O A:HOH430 2.0 19.5 0.5 O A:HOH695 2.1 17.2 0.5 O A:HOH702 2.3 19.3 0.5 O A:HOH526 3.5 42.9 1.0 O A:HOH469 3.9 19.3 1.0 OD2 A:ASP54 4.1 15.0 1.0 O A:HOH404 4.2 38.2 1.0 O A:HOH481 4.3 26.1 1.0 O2P A:CMP301 4.6 21.1 1.0 O A:HOH474 5.0 18.7 1.0 O A:HOH554 5.0 18.2 1.0

G.Tassone, S.Mangani, M.Botta, C.Pozzi. Probing the Role of ARG97 in Heat Shock Protein 90 N-Terminal Domain From the Parasite Leishmania Braziliensis Through Site-Directed Mutagenesis on the Human Counterpart. Biochim Biophys Acta V.1866 1190 2018PROTEINS Proteom.
ISSN: ISSN 1878-1454
PubMed: 30248409
DOI: 10.1016/J.BBAPAP.2018.09.005