Magnesium »
PDB 6hns-6hvv »
6hv7 »
Magnesium in PDB 6hv7: Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7
Enzymatic activity of Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7
All present enzymatic activity of Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7:
3.4.25.1;
3.4.25.1;
Protein crystallography data
The structure of Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7, PDB code: 6hv7
was solved by
E.M.Huber,
M.Groll,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 15.00 / 3.40 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 134.070, 302.110, 143.220, 90.00, 112.56, 90.00 |
| R / Rfree (%) | 17.4 / 22.9 |
Other elements in 6hv7:
The structure of Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7 also contains other interesting chemical elements:
| Chlorine | (Cl) | 2 atoms |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7
(pdb code 6hv7). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 8 binding sites of Magnesium where determined in the Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7, PDB code: 6hv7:
Jump to Magnesium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Magnesium where determined in the Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7, PDB code: 6hv7:
Jump to Magnesium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Magnesium binding site 1 out of 8 in 6hv7
Go back to
Magnesium Binding Sites List in 6hv7
Magnesium binding site 1 out
of 8 in the Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7 within 5.0Å range:
|
Magnesium binding site 2 out of 8 in 6hv7
Go back to
Magnesium Binding Sites List in 6hv7
Magnesium binding site 2 out
of 8 in the Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 2 of Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7 within 5.0Å range:
|
Magnesium binding site 3 out of 8 in 6hv7
Go back to
Magnesium Binding Sites List in 6hv7
Magnesium binding site 3 out
of 8 in the Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 3 of Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7 within 5.0Å range:
|
Magnesium binding site 4 out of 8 in 6hv7
Go back to
Magnesium Binding Sites List in 6hv7
Magnesium binding site 4 out
of 8 in the Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 4 of Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7 within 5.0Å range:
|
Magnesium binding site 5 out of 8 in 6hv7
Go back to
Magnesium Binding Sites List in 6hv7
Magnesium binding site 5 out
of 8 in the Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 5 of Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7 within 5.0Å range:
|
Magnesium binding site 6 out of 8 in 6hv7
Go back to
Magnesium Binding Sites List in 6hv7
Magnesium binding site 6 out
of 8 in the Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 6 of Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7 within 5.0Å range:
|
Magnesium binding site 7 out of 8 in 6hv7
Go back to
Magnesium Binding Sites List in 6hv7
Magnesium binding site 7 out
of 8 in the Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 7 of Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7 within 5.0Å range:
|
Magnesium binding site 8 out of 8 in 6hv7
Go back to
Magnesium Binding Sites List in 6hv7
Magnesium binding site 8 out
of 8 in the Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 8 of Yeast 20S Proteasome with Human BETA2I (1-53) in Complex with 7 within 5.0Å range:
|
Reference:
B.T.Xin,
E.M.Huber,
G.De Bruin,
W.Heinemeyer,
E.Maurits,
C.Espinal,
Y.Du,
M.Janssens,
E.S.Weyburne,
A.F.Kisselev,
B.I.Florea,
C.Driessen,
G.A.Van Der Marel,
M.Groll,
H.S.Overkleeft.
Structure-Based Design of Inhibitors Selective For Human Proteasome Beta 2C or Beta 2I Subunits. J.Med.Chem. V. 62 1626 2019.
ISSN: ISSN 0022-2623
PubMed: 30657666
DOI: 10.1021/ACS.JMEDCHEM.8B01884
Page generated: Tue Oct 1 02:24:17 2024
ISSN: ISSN 0022-2623
PubMed: 30657666
DOI: 10.1021/ACS.JMEDCHEM.8B01884
Last articles
As in 2V98As in 2V97
As in 2VQH
As in 2VDL
As in 2VEQ
As in 2VDK
As in 2V5C
As in 2V96
As in 2RA8
As in 2PQ3
