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Magnesium in PDB 6hwa: Yeast 20S Proteasome in Complex with 43
Enzymatic activity of Yeast 20S Proteasome in Complex with 43
All present enzymatic activity of Yeast 20S Proteasome in Complex with 43:
3.4.25.1;
3.4.25.1;
Protein crystallography data
The structure of Yeast 20S Proteasome in Complex with 43, PDB code: 6hwa
was solved by
E.M.Huber,
M.Groll,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 15.00 / 2.80 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 136.510, 300.440, 146.350, 90.00, 113.61, 90.00 |
| R / Rfree (%) | 18.5 / 21.6 |
Other elements in 6hwa:
The structure of Yeast 20S Proteasome in Complex with 43 also contains other interesting chemical elements:
| Chlorine | (Cl) | 2 atoms |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Yeast 20S Proteasome in Complex with 43
(pdb code 6hwa). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 10 binding sites of Magnesium where determined in the Yeast 20S Proteasome in Complex with 43, PDB code: 6hwa:
Jump to Magnesium binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;
In total 10 binding sites of Magnesium where determined in the Yeast 20S Proteasome in Complex with 43, PDB code: 6hwa:
Jump to Magnesium binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;
Magnesium binding site 1 out of 10 in 6hwa
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Magnesium Binding Sites List in 6hwa
Magnesium binding site 1 out
of 10 in the Yeast 20S Proteasome in Complex with 43
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Yeast 20S Proteasome in Complex with 43 within 5.0Å range:
|
Magnesium binding site 2 out of 10 in 6hwa
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Magnesium Binding Sites List in 6hwa
Magnesium binding site 2 out
of 10 in the Yeast 20S Proteasome in Complex with 43
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 2 of Yeast 20S Proteasome in Complex with 43 within 5.0Å range:
|
Magnesium binding site 3 out of 10 in 6hwa
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Magnesium Binding Sites List in 6hwa
Magnesium binding site 3 out
of 10 in the Yeast 20S Proteasome in Complex with 43
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 3 of Yeast 20S Proteasome in Complex with 43 within 5.0Å range:
|
Magnesium binding site 4 out of 10 in 6hwa
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Magnesium Binding Sites List in 6hwa
Magnesium binding site 4 out
of 10 in the Yeast 20S Proteasome in Complex with 43
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 4 of Yeast 20S Proteasome in Complex with 43 within 5.0Å range:
|
Magnesium binding site 5 out of 10 in 6hwa
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Magnesium Binding Sites List in 6hwa
Magnesium binding site 5 out
of 10 in the Yeast 20S Proteasome in Complex with 43
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 5 of Yeast 20S Proteasome in Complex with 43 within 5.0Å range:
|
Magnesium binding site 6 out of 10 in 6hwa
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Magnesium Binding Sites List in 6hwa
Magnesium binding site 6 out
of 10 in the Yeast 20S Proteasome in Complex with 43
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 6 of Yeast 20S Proteasome in Complex with 43 within 5.0Å range:
|
Magnesium binding site 7 out of 10 in 6hwa
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Magnesium Binding Sites List in 6hwa
Magnesium binding site 7 out
of 10 in the Yeast 20S Proteasome in Complex with 43
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 7 of Yeast 20S Proteasome in Complex with 43 within 5.0Å range:
|
Magnesium binding site 8 out of 10 in 6hwa
Go back to
Magnesium Binding Sites List in 6hwa
Magnesium binding site 8 out
of 10 in the Yeast 20S Proteasome in Complex with 43
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 8 of Yeast 20S Proteasome in Complex with 43 within 5.0Å range:
|
Magnesium binding site 9 out of 10 in 6hwa
Go back to
Magnesium Binding Sites List in 6hwa
Magnesium binding site 9 out
of 10 in the Yeast 20S Proteasome in Complex with 43
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 9 of Yeast 20S Proteasome in Complex with 43 within 5.0Å range:
|
Magnesium binding site 10 out of 10 in 6hwa
Go back to
Magnesium Binding Sites List in 6hwa
Magnesium binding site 10 out
of 10 in the Yeast 20S Proteasome in Complex with 43
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 10 of Yeast 20S Proteasome in Complex with 43 within 5.0Å range:
|
Reference:
B.T.Xin,
E.M.Huber,
G.De Bruin,
W.Heinemeyer,
E.Maurits,
C.Espinal,
Y.Du,
M.Janssens,
E.S.Weyburne,
A.F.Kisselev,
B.I.Florea,
C.Driessen,
G.A.Van Der Marel,
M.Groll,
H.S.Overkleeft.
Structure-Based Design of Inhibitors Selective For Human Proteasome Beta 2C or Beta 2I Subunits. J.Med.Chem. V. 62 1626 2019.
ISSN: ISSN 0022-2623
PubMed: 30657666
DOI: 10.1021/ACS.JMEDCHEM.8B01884
Page generated: Tue Oct 1 02:40:58 2024
ISSN: ISSN 0022-2623
PubMed: 30657666
DOI: 10.1021/ACS.JMEDCHEM.8B01884
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