Magnesium in PDB 6k7k: Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E1-Adp- Pi State)

All present enzymatic activity of Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E1-Adp- Pi State):
7.6.2.1;

The structure of Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E1-Adp- Pi State) also contains other interesting chemical elements:

Fluorine	(F)	4 atoms
Aluminium	(Al)	1 atom

The binding sites of Magnesium atom in the Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E1-Adp- Pi State) (pdb code 6k7k). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E1-Adp- Pi State), PDB code: 6k7k:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E1-Adp- Pi State)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E1-Adp- Pi State) within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1203 b:78.1 occ:1.00 O2B A:ADP1201 2.8 0.8 1.0 OE2 A:GLU807 2.8 69.4 1.0 CD A:GLU807 4.1 69.4 1.0 PB A:ADP1201 4.2 0.8 1.0 ND2 A:ASN789 4.3 61.5 1.0 F1 A:ALF1202 4.6 65.5 1.0 O1A A:ADP1201 4.7 0.8 1.0 O1B A:ADP1201 4.7 0.8 1.0 OE1 A:GLU807 4.8 69.4 1.0 CG A:ASN789 5.0 61.5 1.0

Magnesium binding site 2 out of 2 in the Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E1-Adp- Pi State)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E1-Adp- Pi State) within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1204 b:60.6 occ:1.00 F3 A:ALF1202 2.0 65.5 1.0 O A:THR411 2.1 62.8 1.0 OD1 A:ASP786 2.2 53.8 1.0 OE1 A:GLU807 2.7 69.4 1.0 OD1 A:ASP409 2.8 57.9 1.0 F1 A:ALF1202 2.9 65.5 1.0 CG A:ASP786 3.1 53.8 1.0 C A:THR411 3.3 62.8 1.0 OD2 A:ASP786 3.3 53.8 1.0 AL A:ALF1202 3.4 65.5 1.0 CD A:GLU807 3.7 69.4 1.0 N A:GLY787 3.8 56.7 1.0 OE2 A:GLU807 3.9 69.4 1.0 CA A:GLY412 4.0 57.8 1.0 CG A:ASP409 4.0 57.9 1.0 N A:GLY412 4.1 57.8 1.0 CA A:GLY787 4.2 56.7 1.0 CA A:THR411 4.4 62.8 1.0 OD2 A:ASP790 4.4 55.6 1.0 CB A:ASP786 4.5 53.8 1.0 CB A:THR411 4.5 62.8 1.0 C A:GLY412 4.5 57.8 1.0 F2 A:ALF1202 4.5 65.5 1.0 CG2 A:THR411 4.6 62.8 1.0 C A:ASP786 4.6 53.8 1.0 N A:ASP786 4.6 53.8 1.0 OD2 A:ASP409 4.7 57.9 1.0 N A:THR411 4.7 62.8 1.0 N A:THR413 4.7 52.2 1.0 ND2 A:ASN417 4.8 76.7 1.0 CA A:ASP786 4.8 53.8 1.0 OG1 A:THR413 5.0 52.2 1.0

M.Hiraizumi, K.Yamashita, T.Nishizawa, O.Nureki. Cryo-Em Structures Capture the Transport Cycle of the P4-Atpase Flippase. Science V. 365 1149 2019.
ISSN: ESSN 1095-9203
PubMed: 31416931
DOI: 10.1126/SCIENCE.AAY3353