Magnesium in PDB 6k7m: Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E2PI-Pl State)

All present enzymatic activity of Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E2PI-Pl State):
7.6.2.1;

The structure of Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E2PI-Pl State) also contains other interesting chemical elements:

Fluorine	(F)	4 atoms
Aluminium	(Al)	1 atom

The binding sites of Magnesium atom in the Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E2PI-Pl State) (pdb code 6k7m). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E2PI-Pl State), PDB code: 6k7m:

Magnesium binding site 1 out of 1 in the Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E2PI-Pl State)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E2PI-Pl State) within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1303 b:44.4 occ:1.00 F2 A:ALF1301 2.0 45.6 1.0 OD1 A:ASP786 2.0 39.9 1.0 O A:THR411 2.5 46.7 1.0 OD2 A:ASP409 2.9 41.0 1.0 CG A:ASP786 3.1 39.9 1.0 OD2 A:ASP786 3.5 39.9 1.0 F3 A:ALF1301 3.6 45.6 1.0 AL A:ALF1301 3.6 45.6 1.0 C A:THR411 3.7 46.7 1.0 O A:GLY190 3.8 62.6 1.0 OD2 A:ASP790 3.8 41.2 1.0 N A:GLY787 3.9 43.8 1.0 CA A:GLY190 4.1 62.6 1.0 CG A:ASP409 4.1 41.0 1.0 CA A:GLY787 4.2 43.8 1.0 OD1 A:ASN789 4.4 46.5 1.0 CB A:ASP786 4.4 39.9 1.0 C A:GLY190 4.4 62.6 1.0 CB A:THR411 4.4 46.7 1.0 CA A:THR411 4.5 46.7 1.0 F4 A:ALF1301 4.5 45.6 1.0 C A:ASP786 4.6 39.9 1.0 N A:GLY412 4.6 41.5 1.0 OD1 A:ASP409 4.7 41.0 1.0 N A:ASP786 4.7 39.9 1.0 CG2 A:THR411 4.7 46.7 1.0 CA A:GLY412 4.7 41.5 1.0 N A:THR411 4.8 46.7 1.0 CA A:ASP786 4.8 39.9 1.0 CG A:ASP790 5.0 41.2 1.0

M.Hiraizumi, K.Yamashita, T.Nishizawa, O.Nureki. Cryo-Em Structures Capture the Transport Cycle of the P4-Atpase Flippase. Science V. 365 1149 2019.
ISSN: ESSN 1095-9203
PubMed: 31416931
DOI: 10.1126/SCIENCE.AAY3353