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Atomistry » Magnesium » PDB 6kqk-6l54 » 6l3r | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 6kqk-6l54 » 6l3r » |
Magnesium in PDB 6l3r: Crystal Structure of Ribonucleotide Reductase R1 Subunit, RRM1 in Complex with 4-Bromo-N-((1S,2R)-2-(Naphthalen-1-Yl)-1-(5-Oxo-4,5- Dihydro-1,3,4-Oxadiazol-2-Yl)Propyl)BenzenesulfonamideEnzymatic activity of Crystal Structure of Ribonucleotide Reductase R1 Subunit, RRM1 in Complex with 4-Bromo-N-((1S,2R)-2-(Naphthalen-1-Yl)-1-(5-Oxo-4,5- Dihydro-1,3,4-Oxadiazol-2-Yl)Propyl)Benzenesulfonamide
All present enzymatic activity of Crystal Structure of Ribonucleotide Reductase R1 Subunit, RRM1 in Complex with 4-Bromo-N-((1S,2R)-2-(Naphthalen-1-Yl)-1-(5-Oxo-4,5- Dihydro-1,3,4-Oxadiazol-2-Yl)Propyl)Benzenesulfonamide:
1.17.4.1; Protein crystallography data
The structure of Crystal Structure of Ribonucleotide Reductase R1 Subunit, RRM1 in Complex with 4-Bromo-N-((1S,2R)-2-(Naphthalen-1-Yl)-1-(5-Oxo-4,5- Dihydro-1,3,4-Oxadiazol-2-Yl)Propyl)Benzenesulfonamide, PDB code: 6l3r
was solved by
S.Miyahara,
K.T.Chong,
T.Suzuki,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6l3r:
The structure of Crystal Structure of Ribonucleotide Reductase R1 Subunit, RRM1 in Complex with 4-Bromo-N-((1S,2R)-2-(Naphthalen-1-Yl)-1-(5-Oxo-4,5- Dihydro-1,3,4-Oxadiazol-2-Yl)Propyl)Benzenesulfonamide also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Crystal Structure of Ribonucleotide Reductase R1 Subunit, RRM1 in Complex with 4-Bromo-N-((1S,2R)-2-(Naphthalen-1-Yl)-1-(5-Oxo-4,5- Dihydro-1,3,4-Oxadiazol-2-Yl)Propyl)Benzenesulfonamide
(pdb code 6l3r). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of Ribonucleotide Reductase R1 Subunit, RRM1 in Complex with 4-Bromo-N-((1S,2R)-2-(Naphthalen-1-Yl)-1-(5-Oxo-4,5- Dihydro-1,3,4-Oxadiazol-2-Yl)Propyl)Benzenesulfonamide, PDB code: 6l3r: Jump to Magnesium binding site number: 1; 2; Magnesium binding site 1 out of 2 in 6l3rGo back to Magnesium Binding Sites List in 6l3r
Magnesium binding site 1 out
of 2 in the Crystal Structure of Ribonucleotide Reductase R1 Subunit, RRM1 in Complex with 4-Bromo-N-((1S,2R)-2-(Naphthalen-1-Yl)-1-(5-Oxo-4,5- Dihydro-1,3,4-Oxadiazol-2-Yl)Propyl)Benzenesulfonamide
Mono view Stereo pair view
Magnesium binding site 2 out of 2 in 6l3rGo back to Magnesium Binding Sites List in 6l3r
Magnesium binding site 2 out
of 2 in the Crystal Structure of Ribonucleotide Reductase R1 Subunit, RRM1 in Complex with 4-Bromo-N-((1S,2R)-2-(Naphthalen-1-Yl)-1-(5-Oxo-4,5- Dihydro-1,3,4-Oxadiazol-2-Yl)Propyl)Benzenesulfonamide
Mono view Stereo pair view
Reference:
S.Miyahara,
S.Hara,
K.T.Chong,
T.Suzuki,
Y.Ogino,
T.Hoshino,
S.Tsukioka,
W.Yano,
M.Suzuki,
Y.Otsu,
T.Yonekura,
S.Ito,
M.Terasaka,
T.Suzuki,
A.Hashimoto.
TAS1553, A Novel Small Molecule Ribonucleotide Reductase (Rnr) Subunit Interaction Inhibitor, Displays Remarkable Anti-Tumor Activity To Be Published.
Page generated: Tue Oct 1 10:03:17 2024
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