Magnesium in PDB 6mxb: Crystal Structure of Trypanosoma Brucei Hypoxanthine-Guanine-Xanthine Phosphoribosyltranferase in Complex with Xmp

The structure of Crystal Structure of Trypanosoma Brucei Hypoxanthine-Guanine-Xanthine Phosphoribosyltranferase in Complex with Xmp, PDB code: 6mxb was solved by D.Teran, L.Guddat, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.64 / 2.19
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	61.113, 107.394, 117.097, 90.00, 96.96, 90.00
R / Rfree (%)	18.5 / 22.3

The binding sites of Magnesium atom in the Crystal Structure of Trypanosoma Brucei Hypoxanthine-Guanine-Xanthine Phosphoribosyltranferase in Complex with Xmp (pdb code 6mxb). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Crystal Structure of Trypanosoma Brucei Hypoxanthine-Guanine-Xanthine Phosphoribosyltranferase in Complex with Xmp, PDB code: 6mxb:
Jump to Magnesium binding site number: 1; 2; 3;

Magnesium binding site 1 out of 3 in the Crystal Structure of Trypanosoma Brucei Hypoxanthine-Guanine-Xanthine Phosphoribosyltranferase in Complex with Xmp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Trypanosoma Brucei Hypoxanthine-Guanine-Xanthine Phosphoribosyltranferase in Complex with Xmp within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg302 b:60.5 occ:1.00 OH A:TYR213 2.4 32.8 1.0 OH A:TYR230 2.5 34.1 1.0 OD2 B:ASP76 3.0 49.2 1.0 CZ A:TYR213 3.3 27.5 1.0 CE2 A:TYR213 3.3 26.6 1.0 CG B:ASP76 3.7 43.5 1.0 CB B:ASP76 3.7 35.6 1.0 CZ A:TYR230 3.8 29.0 1.0 NE A:ARG229 4.0 40.6 1.0 O A:HOH415 4.3 38.6 1.0 CE1 A:TYR226 4.3 33.1 1.0 CE1 A:TYR230 4.4 23.6 1.0 CD A:ARG229 4.5 35.4 1.0 CE1 A:TYR213 4.6 25.3 1.0 CD2 A:TYR213 4.7 23.3 1.0 CZ A:ARG229 4.7 46.6 1.0 OD1 B:ASP76 4.7 44.8 1.0 OE2 B:GLU77 4.7 46.6 1.0 CD1 A:TYR226 4.8 30.0 1.0 NH2 A:ARG229 4.8 50.6 1.0 CE2 A:TYR230 4.9 28.1 1.0 CE A:MET29 5.0 29.5 1.0

Magnesium binding site 2 out of 3 in the Crystal Structure of Trypanosoma Brucei Hypoxanthine-Guanine-Xanthine Phosphoribosyltranferase in Complex with Xmp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of Trypanosoma Brucei Hypoxanthine-Guanine-Xanthine Phosphoribosyltranferase in Complex with Xmp within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg303 b:64.6 occ:1.00 O3' A:XMP301 2.4 73.2 1.0 OE2 A:GLU147 2.9 52.1 1.0 O2' A:XMP301 3.3 70.6 1.0 OE1 A:GLU147 3.3 53.5 1.0 OD1 A:ASP148 3.3 38.2 1.0 CD A:GLU147 3.4 49.0 1.0 OD2 A:ASP148 3.6 42.2 1.0 C3' A:XMP301 3.8 70.7 1.0 CG A:ASP148 3.8 37.9 1.0 C2' A:XMP301 4.0 69.6 1.0 CG1 A:VAL85 4.1 21.6 1.0 CG A:GLU147 4.7 38.2 1.0 C4' A:XMP301 4.7 69.3 1.0 CB A:VAL85 4.8 21.9 1.0 O A:LEU86 4.9 31.8 1.0 O A:VAL85 4.9 20.5 1.0 O A:HOH405 5.0 6.3 0.3

Magnesium binding site 3 out of 3 in the Crystal Structure of Trypanosoma Brucei Hypoxanthine-Guanine-Xanthine Phosphoribosyltranferase in Complex with Xmp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Crystal Structure of Trypanosoma Brucei Hypoxanthine-Guanine-Xanthine Phosphoribosyltranferase in Complex with Xmp within 5.0Å range: probe atom residue distance (Å) B Occ D:Mg302 b:62.0 occ:1.00 OE2 D:GLU147 2.3 59.4 1.0 O D:VAL85 3.0 24.4 1.0 OG D:SER89 3.1 23.6 0.6 OD1 D:ASP148 3.2 45.2 1.0 CG D:ASP148 3.3 45.4 1.0 CD D:GLU147 3.4 56.4 1.0 OD2 D:ASP148 3.4 48.6 1.0 CG1 D:VAL85 3.5 25.5 1.0 N D:GLY88 3.6 21.8 1.0 CA D:GLY88 3.7 23.2 1.0 CB D:VAL85 3.8 24.1 1.0 OE1 D:GLU147 3.8 59.3 1.0 N D:SER89 3.8 21.6 0.6 N D:SER89 3.8 21.8 0.4 C D:VAL85 3.8 23.8 1.0 C D:GLY88 3.9 24.8 1.0 N D:ASP148 4.0 31.9 1.0 CB D:ASP148 4.1 40.7 1.0 CB D:SER89 4.2 21.3 0.4 CB D:SER89 4.2 21.2 0.6 CA D:VAL85 4.4 22.5 1.0 C D:LEU86 4.6 26.2 1.0 CG D:GLU147 4.6 48.4 1.0 CA D:SER89 4.6 20.9 0.6 CA D:SER89 4.6 21.0 0.4 O D:LEU86 4.6 23.8 1.0 OG D:SER89 4.7 21.0 0.4 CA D:ASP148 4.7 34.8 1.0 N D:LYS87 4.7 26.3 1.0 N D:LEU86 4.7 21.6 1.0 C D:LYS87 4.7 23.3 1.0 O D:GLY88 4.8 27.1 1.0 CA D:GLU147 4.8 33.2 1.0 C D:GLU147 4.9 30.3 1.0 O3' D:XMP301 4.9 66.2 1.0 CA D:LEU86 5.0 22.9 1.0

D.Teran, E.Dolezelova, D.T.Keough, D.Hockova, A.Zikova, L.W.Guddat. Crystal Structures of Trypanosoma Brucei Hypoxanthine - Guanine - Xanthine Phosphoribosyltransferase in Complex with Imp, Gmp and Xmp. Febs J. 2019.
ISSN: ISSN 1742-464X
PubMed: 31287615
DOI: 10.1111/FEBS.14987