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Magnesium in PDB 6p1p: Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Bound Incoming Dcmpnpp
Enzymatic activity of Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Bound Incoming Dcmpnpp
All present enzymatic activity of Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Bound Incoming Dcmpnpp:
2.7.7.7;
2.7.7.7;
Protein crystallography data
The structure of Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Bound Incoming Dcmpnpp, PDB code: 6p1p
was solved by
A.M.Kaminski,
L.C.Pedersen,
K.Bebenek,
K.K.Chiruvella,
D.A.Ramsden,
T.A.Kunkel,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 25.08 / 1.75 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 59.940, 68.608, 110.282, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 16.5 / 18.4 |
Other elements in 6p1p:
The structure of Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Bound Incoming Dcmpnpp also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
| Sodium | (Na) | 1 atom |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Bound Incoming Dcmpnpp
(pdb code 6p1p). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Bound Incoming Dcmpnpp, PDB code: 6p1p:
Jump to Magnesium binding site number: 1; 2;
In total 2 binding sites of Magnesium where determined in the Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Bound Incoming Dcmpnpp, PDB code: 6p1p:
Jump to Magnesium binding site number: 1; 2;
Magnesium binding site 1 out of 2 in 6p1p
Go back to
Magnesium Binding Sites List in 6p1p
Magnesium binding site 1 out
of 2 in the Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Bound Incoming Dcmpnpp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Bound Incoming Dcmpnpp within 5.0Å range:
|
Magnesium binding site 2 out of 2 in 6p1p
Go back to
Magnesium Binding Sites List in 6p1p
Magnesium binding site 2 out
of 2 in the Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Bound Incoming Dcmpnpp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 2 of Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Bound Incoming Dcmpnpp within 5.0Å range:
|
Reference:
A.M.Kaminski,
K.K.Chiruvella,
D.A.Ramsden,
T.A.Kunkel,
K.Bebenek,
L.C.Pedersen.
Unexpected Behavior of Dna Polymerase Mu Opposite Template 8-Oxo-7,8-Dihydro-2'-Guanosine. Nucleic Acids Res. V. 47 9410 2019.
ISSN: ESSN 1362-4962
PubMed: 31435651
DOI: 10.1093/NAR/GKZ680
Page generated: Tue Oct 1 13:49:15 2024
ISSN: ESSN 1362-4962
PubMed: 31435651
DOI: 10.1093/NAR/GKZ680
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