Magnesium in PDB 6q21: Molecular Switch For Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic Ras Proteins

Protein crystallography data

The structure of Molecular Switch For Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic Ras Proteins, PDB code: 6q21 was solved by S.-H.Kim, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) N/A / 1.95
Space group P 1 1 21
Cell size a, b, c (Å), α, β, γ (°) 41.980, 79.120, 128.500, 90.00, 90.00, 117.48
R / Rfree (%) 19 / n/a

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Molecular Switch For Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic Ras Proteins (pdb code 6q21). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 4 binding sites of Magnesium where determined in the Molecular Switch For Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic Ras Proteins, PDB code: 6q21:
Jump to Magnesium binding site number: 1; 2; 3; 4;

Magnesium binding site 1 out of 4 in 6q21

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Magnesium binding site 1 out of 4 in the Molecular Switch For Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic Ras Proteins


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Molecular Switch For Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic Ras Proteins within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg173

b:34.1
occ:1.00
 O A:HOH801 1.9 26.8 1.0
O1G A:GCP180 2.0 45.4 1.0
O A:HOH800 2.1 35.5 1.0
O1B A:GCP180 2.1 42.1 1.0
OG1 A:THR35 2.3 66.5 1.0
OG A:SER17 2.4 28.7 1.0
PG A:GCP180 3.1 56.1 1.0
C3B A:GCP180 3.2 50.0 1.0
CB A:THR35 3.2 65.6 1.0
PB A:GCP180 3.2 42.6 1.0
CB A:SER17 3.4 36.7 1.0
O2G A:GCP180 3.8 51.0 1.0
O A:THR58 3.9 35.1 1.0
N A:SER17 4.0 41.5 1.0
OD2 A:ASP57 4.0 36.1 1.0
OD1 A:ASP57 4.0 50.8 1.0
CG2 A:THR35 4.1 68.5 1.0
NZ A:LYS16 4.1 26.9 1.0
O2B A:GCP180 4.2 32.5 1.0
N A:THR35 4.2 59.9 1.0
CA A:SER17 4.2 35.1 1.0
O3G A:GCP180 4.3 50.1 1.0
O3A A:GCP180 4.3 26.2 1.0
CG A:ASP57 4.4 39.6 1.0
O1A A:GCP180 4.4 29.8 1.0
CB A:LYS16 4.4 30.5 1.0
CA A:THR35 4.5 61.4 1.0
O2A A:GCP180 4.6 41.2 1.0
PA A:GCP180 4.7 38.7 1.0
O A:ASP33 4.7 66.9 1.0
CB A:ALA59 4.7 47.3 1.0
CA A:ALA59 5.0 57.7 1.0

Magnesium binding site 2 out of 4 in 6q21

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Magnesium binding site 2 out of 4 in the Molecular Switch For Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic Ras Proteins


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Molecular Switch For Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic Ras Proteins within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg173

b:30.1
occ:1.00
 O B:HOH804 1.9 26.3 0.9
OG B:SER17 2.0 23.3 1.0
O2G B:GCP180 2.1 34.2 1.0
O1B B:GCP180 2.1 32.2 1.0
O B:HOH803 2.3 17.3 0.9
OG1 B:THR35 2.3 30.0 1.0
CB B:SER17 3.1 23.6 1.0
PB B:GCP180 3.3 30.6 1.0
CB B:THR35 3.4 29.1 1.0
PG B:GCP180 3.4 33.2 1.0
C3B B:GCP180 3.6 38.0 1.0
N B:SER17 3.7 25.9 1.0
OD2 B:ASP57 3.9 27.7 1.0
CA B:SER17 3.9 29.1 1.0
O1A B:GCP180 4.1 33.6 1.0
CG2 B:THR35 4.1 19.2 1.0
OD1 B:ASP57 4.2 33.8 1.0
O B:HOH904 4.2 31.1 1.0
O2B B:GCP180 4.3 31.4 1.0
O3A B:GCP180 4.3 19.2 1.0
O B:THR58 4.3 23.4 1.0
O1G B:GCP180 4.4 36.3 1.0
CG B:ASP57 4.4 21.9 1.0
O3G B:GCP180 4.5 29.1 1.0
PA B:GCP180 4.6 26.8 1.0
N B:THR35 4.6 35.8 1.0
CB B:LYS16 4.6 23.5 1.0
CA B:THR35 4.6 16.9 1.0
O2A B:GCP180 4.6 38.8 1.0
O B:ASP33 4.7 39.4 1.0
C B:PRO34 4.7 39.8 1.0
C B:LYS16 4.8 24.5 1.0
O B:HOH900 4.9 38.8 0.9
O B:PRO34 4.9 51.2 1.0

Magnesium binding site 3 out of 4 in 6q21

Go back to Magnesium Binding Sites List in 6q21
Magnesium binding site 3 out of 4 in the Molecular Switch For Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic Ras Proteins


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Molecular Switch For Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic Ras Proteins within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Mg173

b:25.7
occ:1.00
 O3G C:GCP180 2.0 15.2 1.0
OG C:SER17 2.1 15.4 1.0
O C:HOH807 2.1 17.8 0.9
O1B C:GCP180 2.2 23.8 1.0
OG1 C:THR35 2.2 17.3 1.0
O C:HOH806 2.3 21.4 1.0
CB C:THR35 3.1 12.5 1.0
PB C:GCP180 3.2 22.2 1.0
PG C:GCP180 3.2 17.6 1.0
CB C:SER17 3.3 14.4 1.0
C3B C:GCP180 3.5 24.7 1.0
N C:SER17 3.9 21.0 1.0
N C:THR35 3.9 30.9 1.0
OD1 C:ASP57 4.1 30.2 1.0
CA C:SER17 4.1 11.4 1.0
CG2 C:THR35 4.1 3.6 1.0
CA C:THR35 4.2 20.8 1.0
O1G C:GCP180 4.2 13.5 1.0
O3A C:GCP180 4.2 12.9 1.0
OD2 C:ASP57 4.2 22.7 1.0
O2G C:GCP180 4.2 28.9 1.0
O1A C:GCP180 4.3 30.4 1.0
O C:THR58 4.3 18.8 1.0
O2B C:GCP180 4.4 25.4 1.0
CG C:ASP57 4.5 18.3 1.0
PA C:GCP180 4.6 19.4 1.0
CB C:LYS16 4.6 10.4 1.0
O C:ASP33 4.6 31.5 1.0
O2A C:GCP180 4.7 16.0 1.0
O C:HOH910 4.8 46.3 1.0
CE C:LYS16 4.8 20.4 1.0
NZ C:LYS16 4.8 28.4 1.0
C C:LYS16 4.9 15.5 1.0
C C:PRO34 4.9 27.3 1.0

Magnesium binding site 4 out of 4 in 6q21

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Magnesium binding site 4 out of 4 in the Molecular Switch For Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic Ras Proteins


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 4 of Molecular Switch For Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic Ras Proteins within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Mg173

b:25.3
occ:1.00
 O3G D:GCP180 1.9 37.6 1.0
O D:HOH810 1.9 27.8 1.0
O1B D:GCP180 2.0 31.2 1.0
O D:HOH812 2.0 10.1 1.0
OG D:SER17 2.1 25.7 1.0
O D:HOH809 2.1 24.0 1.0
PG D:GCP180 3.1 45.9 1.0
CB D:SER17 3.2 19.2 1.0
PB D:GCP180 3.2 31.2 1.0
C3B D:GCP180 3.4 38.0 1.0
O1G D:GCP180 3.6 46.8 1.0
N D:SER17 3.9 26.7 1.0
OD2 D:ASP57 3.9 33.3 1.0
O1A D:GCP180 4.0 22.9 1.0
CA D:SER17 4.0 30.4 1.0
O2B D:GCP180 4.1 32.4 1.0
CD2 D:TYR32 4.2 49.9 1.0
OD1 D:ASP57 4.2 31.8 1.0
O3A D:GCP180 4.3 19.6 1.0
O2G D:GCP180 4.4 47.2 1.0
CE2 D:TYR32 4.4 58.2 1.0
O D:ASP33 4.5 55.9 1.0
CG D:ASP57 4.5 22.0 1.0
O D:THR58 4.5 24.7 1.0
CA D:PRO34 4.6 53.7 1.0
PA D:GCP180 4.6 22.1 1.0
C D:ASP33 4.6 63.0 1.0
N D:PRO34 4.7 60.0 1.0
CB D:LYS16 4.8 16.9 1.0
O2A D:GCP180 4.8 32.7 1.0
O D:HOH813 4.8 59.2 0.9
CE D:LYS16 4.9 29.7 1.0
C D:LYS16 4.9 35.5 1.0
O D:HOH872 5.0 44.5 0.9
NZ D:LYS16 5.0 33.6 1.0

Reference:

M.V.Milburn, L.Tong, A.M.Devos, A.Brunger, Z.Yamaizumi, S.Nishimura, S.H.Kim. Molecular Switch For Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic Ras Proteins. Science V. 247 939 1990.
ISSN: ISSN 0036-8075
PubMed: 2406906
Page generated: Mon Dec 14 23:51:25 2020

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