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Atomistry » Magnesium » PDB 6s43-6ses » 6s43 » |
Magnesium in PDB 6s43: Fumarate Hydratase of Mycobacterium Tuberculosis in Complex with Formate and Allosteric Modulator N-(5-(Azocan-1-Ylsulfonyl)-2- Methoxyphenyl)-2-(4-Oxo-3,4-Dihydrophthalazin-1-Yl)AcetamideEnzymatic activity of Fumarate Hydratase of Mycobacterium Tuberculosis in Complex with Formate and Allosteric Modulator N-(5-(Azocan-1-Ylsulfonyl)-2- Methoxyphenyl)-2-(4-Oxo-3,4-Dihydrophthalazin-1-Yl)Acetamide
All present enzymatic activity of Fumarate Hydratase of Mycobacterium Tuberculosis in Complex with Formate and Allosteric Modulator N-(5-(Azocan-1-Ylsulfonyl)-2- Methoxyphenyl)-2-(4-Oxo-3,4-Dihydrophthalazin-1-Yl)Acetamide:
4.2.1.2; Protein crystallography data
The structure of Fumarate Hydratase of Mycobacterium Tuberculosis in Complex with Formate and Allosteric Modulator N-(5-(Azocan-1-Ylsulfonyl)-2- Methoxyphenyl)-2-(4-Oxo-3,4-Dihydrophthalazin-1-Yl)Acetamide, PDB code: 6s43
was solved by
A.J.Whitehouse,
M.D.Libardo,
M.Kasbekar,
P.Brear,
G.Fischer,
C.J.Thomas,
C.E.Barry,
H.I.Boshoff,
A.G.Coyne,
C.Abell,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Fumarate Hydratase of Mycobacterium Tuberculosis in Complex with Formate and Allosteric Modulator N-(5-(Azocan-1-Ylsulfonyl)-2- Methoxyphenyl)-2-(4-Oxo-3,4-Dihydrophthalazin-1-Yl)Acetamide
(pdb code 6s43). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Fumarate Hydratase of Mycobacterium Tuberculosis in Complex with Formate and Allosteric Modulator N-(5-(Azocan-1-Ylsulfonyl)-2- Methoxyphenyl)-2-(4-Oxo-3,4-Dihydrophthalazin-1-Yl)Acetamide, PDB code: 6s43: Jump to Magnesium binding site number: 1; 2; Magnesium binding site 1 out of 2 in 6s43Go back to Magnesium Binding Sites List in 6s43
Magnesium binding site 1 out
of 2 in the Fumarate Hydratase of Mycobacterium Tuberculosis in Complex with Formate and Allosteric Modulator N-(5-(Azocan-1-Ylsulfonyl)-2- Methoxyphenyl)-2-(4-Oxo-3,4-Dihydrophthalazin-1-Yl)Acetamide
Mono view Stereo pair view
Magnesium binding site 2 out of 2 in 6s43Go back to Magnesium Binding Sites List in 6s43
Magnesium binding site 2 out
of 2 in the Fumarate Hydratase of Mycobacterium Tuberculosis in Complex with Formate and Allosteric Modulator N-(5-(Azocan-1-Ylsulfonyl)-2- Methoxyphenyl)-2-(4-Oxo-3,4-Dihydrophthalazin-1-Yl)Acetamide
Mono view Stereo pair view
Reference:
A.J.Whitehouse,
M.D.J.Libardo,
M.Kasbekar,
P.D.Brear,
G.Fischer,
C.J.Thomas,
C.Barry,
H.I.M.Boshoff,
A.G.Coyne,
C.Abell.
Targeting of Fumarate Hydratase From Mycobacterium Tuberculosis Using Allosteric Inhibitors with A Dimeric-Binding Mode. J.Med.Chem. 2019.
Page generated: Tue Oct 1 17:46:46 2024
ISSN: ISSN 0022-2623 PubMed: 31517489 DOI: 10.1021/ACS.JMEDCHEM.9B01203 |
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